NASAL DELIVERY DEVICES

• US 20160051778A1
• Filed: 03/31/2015
• Published: 02/25/2016
• Est. Priority Date: 11/28/2006
• Status: Active Grant

• Current Assignee: OptiNose, Inc.
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle, Sheldrake, Colin David, Smith, Simon, Striebig, Rachel, Pidgeon, Andy, St. Quintin, Tom
• Granted Patent: US 10,525,218 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 15/0018 with exhalation check valves
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0026 Hinged caps
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0035 Piercing means
• CPC Class Codes: A61M 15/0041 with movable piercing or cutting means
• CPC Class Codes: A61M 15/0043 Non-destructive separation of the package, e.g. peeling
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 16/1045 Devices for humidifying or heating the inspired gas by using recovered moisture or heat from the expired gas
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/0222 Materials for reducing friction
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 2210/0625 Mouth

Abstract

A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.

Claims

1-9. -9. (canceled)

10. A nasal delivery device for delivering a particulate substance to the nasal airway of a subject, the delivery device comprising:

a mouthpiece unit which includes a mouthpiece through which the subject in use exhales;

a nosepiece unit which includes a nosepiece for fitting to a nostril of the subject; and

a substance-supply unit which is configured to receive a container containing the particulate substance, the substance-supply unit operable to provide a metered amount of the particulate substance, such that an exhalation air flow delivered through the substance-supply unit entrains the substance.

11. The delivery device of claim 10, wherein the container comprises first and second parts which together define an enclosed chamber and are movable between a first, closed configuration in which the container is closed and a second, open configuration in which the container is open and the substance-supply unit is operable to move the first and second parts of the container to the open configuration.

12. The delivery device of claim 11, wherein the first and second parts of the container are slideably disposed relative to one another and each include at least one aperture, wherein the aperture of the first part and the aperture of the second part are covered when the first and second parts in the closed configuration and the aperture of the first part and the aperture of the second part are uncovered when the first and second parts of the container are in the open configuration.

13. The delivery device of claim 11, wherein the substance-supply unit comprises a support member and a body section that is movable relative to the support member between a first, container-receiving position for receiving a container in which the container is not disposed in fluid communication with the mouthpiece unit and the nosepiece unit, and a second, operative position in which the container is in fluid communication with the mouthpiece and nosepiece units.

14. The delivery device of claim 13, wherein the body section is configured to rotate relative to the support member.

15. The delivery device of claim 14, wherein the body section includes a container-receiving aperture, wherein the container-receiving aperture is uncovered when the body section is in the container-receiving position and is covered when the body section is in the operative position.

16. The delivery device of claim 14, wherein one of the support member and the body section includes an inlet aperture which is fluidly isolated from the mouthpiece unit when the body section is in the container-receiving position and fluidly connected to the mouthpiece unit when the body section is in the operative position.

19. The delivery device of claim 10, further comprising:

a housing which supports the mouthpiece unit, the nosepiece unit and the substance-supply unit.

20. The delivery device of claim 19, wherein the substance-supply unit includes a container-receiving member which is movably disposed between an open position for enabling loading of a container into the container-receiving member, and a closed position in which the container is contained within the housing.

21. The delivery device of claim 20, wherein the container-receiving member includes a cavity which defines an exhalation flow channel between the mouthpiece unit and the nosepiece unit such that an exhalation flow is delivered through the exhalation flow channel on exhalation by the subject through the mouthpiece.

24. The delivery device of claim 20, wherein the substance-supply unit includes a locking mechanism for locking the container-receiving member in the closed position.

17. (canceled)

18. (canceled)

22. (canceled)

23. (canceled)

25. A nasal delivery device for delivering a particulate substance to the nasal airway of a subject comprising:

a body assembly including a mouthpiece unit and a substance-supply unit, the mouthpiece unit including a mouthpiece through which the subject in use exhales, the substance-supply unit being fluidly connected to the mouthpiece unit;

wherein the body assembly is configured to receive a replaceable nosepiece unit.

26. The delivery device of claim 25, further comprising:

a replaceable nosepiece unit including a nosepiece for fitting to a nostril of a subject, and a container chamber which contains a container containing the particulate substance.

27. The delivery device of claim 25, wherein the delivery device is configured to block operation until a nosepiece unit is fitted to the body assembly.

28. The delivery device of claim 27, wherein the body assembly includes an actuation mechanism which is manually actuatable by the subject to open the container, and the delivery device is configured to prevent actuation of the actuation mechanism until the nosepiece unit is fitted to the body assembly.

29-47. -47. (canceled)