COMPOSITIONS AND METHODS FOR THE REDUCTION OR PREVENTION OF HEPATIC STEATOSIS
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Abstract
Methods useful for reducing or preventing non-alcoholic steatohepatitis or hepatic steatosis are provided herein. Such methods may comprise administering to a subject in need thereof a sirtuin pathway activator and/or PDE5 inhibitor alone or in combination with an amount of a branched amino acid in free amino acid form, or a metabolite thereof. Also provided herein are compositions and kits for practicing any of the methods described herein.
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Citations
103 Claims
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1-72. -72. (canceled)
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73. A method of reducing non-alcoholic steatohepatitis (NASH) in a subject in need thereof, comprising administering to the subject a composition comprising:
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a) an amount of leucine in the form of a free amino acid and/or metabolite thereof; and b) an amount of one or more sirtuin pathway activators. - View Dependent Claims (74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100)
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101. A method of preventing non-alcoholic steatohepatitis (NASH) in a subject exhibiting a propensity to hepatic steatosis, comprising administering to the subject prior to manifestation of a hepatic steatosis symptom:
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a. an amount of leucine in the form of a free amino acid and/or metabolite thereof; and b. an amount of one or more sirtuin pathway activators. - View Dependent Claims (102, 103)
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Specification