ANTI-AGING SKIN CARE COMPOSITIONS AND REGIMENS
First Claim
1. A multi-step regimen effective for improving the appearance of aging human skin, the regimen comprising:
- (a) identifying a target portion of skin that exhibits a sign of skin aging;
(b) topically applying a first formulation comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin, and(c) topically applying a second formulation comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin,wherein application of (c) follows application of (b).
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Accused Products
Abstract
Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.
3 Citations
32 Claims
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1. A multi-step regimen effective for improving the appearance of aging human skin, the regimen comprising:
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(a) identifying a target portion of skin that exhibits a sign of skin aging; (b) topically applying a first formulation comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin, and (c) topically applying a second formulation comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin, wherein application of (c) follows application of (b). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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- 17. A cosmetic skin treatment kit comprising a first skin care composition and a second skin care composition separately contained, the first composition formulated to comprise at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification to the target portion of skin, the second composition formulated to comprise at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding, instructions to apply the first composition to a target area of skin prior to applying the second composition to the target area of skin, and, optionally, at least one applicator to effectuate topical application of the first and/or the second skin care composition to the target area of skin.
- 23. The kit according to claim 23, wherein the palmitoyl peptide derivative comprises Pal-KT and the carob seed derivative comprises Glyco-Repair™
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30. A method for identifying an agent effective for transcriptionally up-regulating an eigengene associated with a desirable cosmetic phenotype of human skin, the method comprising:
- deriving an eigengene for a co-expression module determined from a set of genes transcriptionally up-regulated in human skin exhibiting the desirable cosmetic phenotypic and a set of genes associated with one or more biological themes;
treating skin with a putative agent;
conducting a transcriptional assessment of the eigengene in the treated skin; and
identifying the putative agent as an effective agent if the eigengene is up-regulated in the treated skin.
- deriving an eigengene for a co-expression module determined from a set of genes transcriptionally up-regulated in human skin exhibiting the desirable cosmetic phenotypic and a set of genes associated with one or more biological themes;
- 31. An eigengene derived from a co-expression module of a first set of genes differentially expressed in a desirable cosmetic phenotype and a second set of genes implicated in a biological pathway over-represented in the first set of genes.
Specification