SYSTEM AND METHOD FOR CAPTURING DOSE INFORMATION

• US 20160074587A1
• Filed: 09/14/2014
• Published: 03/17/2016
• Est. Priority Date: 09/14/2014
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Searle, Gary, Ross, III, Francis L.
• Granted Patent: US 10,704,944 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3389 Continuous level detection A61M2205/3393 takes precedence
• CPC Class Codes: A61M 2205/3576 with non implanted data transmission devices, e.g. using external transmitter or receiver
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/16804 Flow controllers
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61M 5/1782 Devices aiding filling of syringes in situ combination of a vial and a syringe for transferring or mixing their contents A61J1/2096, filling of medical containers in general B65B3/003
• CPC Class Codes: A61M 5/31511 Piston or piston-rod constructions, e.g. connection of piston with piston-rod A61M5/5066 takes precedence
• CPC Class Codes: B65B 3/003 Filling medical containers such as ampoules, vials, syringes or the like
• CPC Class Codes: G01F 11/027 of the syringe type
• CPC Class Codes: G01R 33/072 Constructional adaptation of the sensor to specific applications
• CPC Class Codes: G16H 20/17 delivered via infusion or injection

Abstract

A system for capture of dose delivery information is provided. The system includes a medication delivery device, a dose information capture device adapted to be attached to the medication delivery device, and a target element adapted to be attached to the medication delivery device. The target element comprises a magnet or ferrous element and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device. The dose information capture device includes a magnetic position sensor adapted to detect a position of the target element. As an alternative to magnetic sensing, MEMS flow sensors, and the like may also be used. Exemplary systems preferably transmit dose information in real time to remote devices for further processing.

Claims

1. A device for capturing delivered dose information, comprising:

a medication delivery device;

a dose information capture device adapted to be attached to the medication delivery device; and

a target element adapted to be attached to the medication delivery device;

wherein the target element comprises a magnet or a ferrous element, and the target element attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device, and

wherein the dose information capture device includes a magnetic position sensor adapted to detect a position of the target element.

2. The device of claim 1, wherein the medication delivery device comprises an RFID chip.

3. The device of claim 1, wherein the dose information capture device comprises a linear magnet position sensor.

4. The device of claim 1 wherein the dose information capture device comprises a Hall-effect sensor.

5. The device of claim 1 wherein the dose information capture device comprises a magnetoresistive (MR) sensor.

6. The device of claim 1 wherein the dose information capture device comprises an anisotropic magnetoresistive (AMR) sensor.

7. The device of claim 1, wherein the dose information capture device comprises a rotational magnet position sensor.

8. The device of claim 1, wherein the medication delivery device is a syringe and the sensor element attaches to the plunger.

9. A device for capturing delivered dose information, comprising:

a medication delivery device;

a dose information capture device adapted to be attached to the medication delivery device, wherein the dose information capture device comprises a MEMS sensor, and the MEMS sensor attaches to the medication delivery device on a dose delivery mechanism of the medication delivery device;

a processor that receives sensor signals from the MEMS sensor; and

a memory comprising instructions adapted to be executed by the processor for determining a dose delivered based on signals received from the MEMS sensor.

10. The device of claim 9, wherein the MEMS sensor is a MEMS Coriolis sensor.

11. The device of claim 9, wherein the MEMS sensor comprises a plurality of MEMS capacitive pressure differential sensors.

12. The device of claim 9, wherein the MEMS sensor is a MEMS thermal time-of-flight sensor.

13. A system for capturing delivered dose information, comprising:

a medicament vial having a medicament volume sensor attached to a sidewall of the medicament vial;

a processor; and

a memory comprising instructions adapted to control the processor to receive medicament volume measurements from the medicament volume sensor, and to determine a difference in volume prior to a dose delivery and after the dose delivery.

14. The system of claim 13, wherein the medicament volume sensor comprises a capacitance sensor attached to a sidewall of the medicament vial.

15. The system of claim 13, further comprising a magnetic ring having a diameter substantially similar but small than an inner diameter of the medicament vial, the magnetic ring being disposed in the medicament vial, and having a density less than a density of a medicament in the medicament vial;

and wherein the medicament volume sensor comprises a magnetic sensor in proximity to the medicament vial to detect a location of the magnetic ring within the medicament vial.

16. The system of claim 13, further comprising a plurality of magnetic beads having a density less than a density of a medicament within the medicament vial, the plurality of magnetic beads being disposed within the medicament vial and floating within the medicament in the medicament vial;

and wherein the medicament volume sensor comprises a magnetic sensor in proximity to the medicament vial to detect a location of the magnetic beads within the medicament vial.

17. The system of claim 13, wherein the number of magnetic beads is sufficient to substantially cover an exposed surface of the medicament within the vial.

18. A system for determining doses of medicament delivered to a patient comprising:

a syringe having a target element movable together with a syringe plunger;

a dose information capture device adapted to be attached to the syringe, the dose information capture device comprising a magnetic sensor arranged to sense a position of the target element when the dose information capture device is attached to the syringe;

a processor; and

a memory comprising instructions adapted to control the processor to determine a dose delivered based on at least one position determination of the plunger.

19. The system of claim 18, further comprising a transceiver adapted to transmit determined dose information to a remote device.

20. An informatically enabled dosing system for improved treatment of diseases comprising:

an insulin dose input element;

an oral medication input element;

a blood glucose level input element; and

a carbohydrate input element;

wherein the system further comprises a data hub adapted to receive data from each of the input elements to perform calculations based on the data received from the input elements, and to provide feedback to a user based on said performed calculations.

21. The system of claim 20, wherein said insulin dose input element comprises a smart dose determination device comprising a transceiver adapted to transmit substantially real-time dose information to the data hub when a dose is administered to a user.

22. The system of claim 20 wherein the oral medication input element comprises an informatically enabled oral medication container that communicates to an application running on a smartphone, adapted to receive a user input corresponding to an oral medication amount taken by the user.

23. The system of claim 20, wherein the blood glucose level input element comprises a blood glucose monitor comprising a transceiver adapted to transmit blood glucose data to the data hub.

24. The system of claim 23, wherein the blood glucose monitor is a continuous glucose monitor.

25. The system of claim 20, wherein the carbohydrate input element comprises an application running on a smartphone, adapted to receive a user input corresponding to food and/or drink ingested by the user, and wherein the application is adapted to estimate carbohydrates ingested by the user from the user input.

26. The system of claim 20, further comprising a wellness data input element.

27. The system of claim 26, wherein the wellness data input element comprises an application running on a smartphone and adapted to receive user input related to wellness data and to transmit said wellness data to the data hub.

28. An informatics enabled pen case adapted to receive an insulin pen comprising:

a syringe receiving cavity;

a clamping system adjacent to the syringe receiving cavity and adapted to clamp onto a plunger of the syringe;

an actuator adapted to move the clamping system and plunger when the clamping system is clamped onto the plunger;

a processor adapted to receive dose commands from the transceiver and to send control information to a controller;

wherein the controller is adapted to operate the actuator and the clamping system, and

a transceiver adapted to receive a dose command from a user interface;

wherein the transceiver transmits a received dose command to the processor; and

wherein the processor receives the dose command, and sends control information corresponding to the dose command to the controller;

wherein the controller receives the control information and controls the clamping system and actuator to clamp the plunger of the syringe and move the plunger to draw a dose corresponding to the dose command.

29. The informatics enabled pen case of claim 28, wherein the user interface comprises an application running on a smartphone.

30. An informatically enabled medicine delivery device and device case, comprising:

a medicine delivery device adapted to receive a removable reservoir filled with medicine, the reservoir comprising a plunger adapted to move axially within the reservoir to cause medicine to exit the reservoir, the plunger comprising a target element attached to the plunger and moving axially with the plunger; and

a device case comprising a cavity corresponding to the medicine delivery device and shaped to receive the medicine delivery device in a predetermined location and a target element sensor adapted to sense the location of the target element;

the device case further comprising a processor adapted to receive a signal from the target element sensor, a real time clock, a memory for storing target element locations sensed by the target element sensor, and a wireless transceiver;

the processor adapted to determine a dose and a time of dose based on target element sensor signals and the real time clock and to send the determined dose and time of dose to the wireless transceiver; and

the wireless transceiver adapted to transmit the determined dose and time of dose to a remote device.

31. The medicine delivery device and device case of claim 30, wherein the medicine delivery device is an insulin pen.

33. The medicine delivery device and device case of claim 30, wherein the medicine delivery device is an insulin pen and the device cap is a smart pen cap.

32. An informatically enabled medicine delivery device comprising:

a medicine delivery device adapted to receive a removable reservoir filled with medicine, the reservoir comprising a plunger adapted to move axially within the reservoir to cause medicine to exit the reservoir, the plunger comprising a target element attached to the plunger and moving axially with the plunger; and

a device cap adapted to receive the medicine delivery device and enclose a deliver end of the medicine delivery device;

the device cap comprising a target element sensor adapted to sense the location of the target element;

the device cap further comprising a processor adapted to receive a signal from the target element sensor, a real time clock, a memory for storing target element locations sensed by the target element sensor, and a wireless transceiver;

the processor adapted to determine a dose and a time of dose based on target element sensor signals and the real time clock and to send the determined dose and time of dose to the wireless transceiver; and

the wireless transceiver adapted to transmit the determined dose and time of dose to a remote device.