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METHOD OF INACTIVATING A GLUCOCORTICOID RECEPTOR GENE IN AN ISOLATED CELL

  • US 20160076056A1
  • Filed: 11/20/2015
  • Published: 03/17/2016
  • Est. Priority Date: 11/13/2006
  • Status: Active Grant
First Claim
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1. A zinc finger nuclease (ZFN) fusion protein comprising a cleavage domain and a zinc-finger protein (ZFP) that binds to a target site in a glucocorticoid receptor (GR) gene, wherein the ZFP comprises 4 or 5 engineered zinc-finger binding domains, each zinc finger domain comprising a recognition helix region designated F1 to F4 or F1 to F5, wherein the zinc finger protein comprises the recognition helix regions as shown in a single row of Table 2 and further wherein the target site is selected from the group consisting of SEQ ID NOs:

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