TOMOGRAPHIC IMAGE GENERATION DEVICE AND METHOD, AND RECORDING MEDIUM

• US 20160081645A1
• Filed: 09/15/2015
• Published: 03/24/2016
• Est. Priority Date: 09/19/2014
• Status: Active Grant

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Inventors: FUKUDA, Wataru
• Granted Patent: US 9,861,332 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 6/025 Tomosynthesis
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/5205 involving processing of raw data to produce diagnostic data
• CPC Class Codes: A61B 6/5258 involving detection or reduction of artifacts or noise
• CPC Class Codes: A61B 6/587 Alignment of source unit to detector unit

Abstract

An image obtaining unit obtains a plurality of projection images by imaging a subject with different radiation source positions. A pixel value projecting unit projects pixel values of the projection images on coordinate positions on a desired slice plane of the subject based on the positional relationship between the radiation source position with which each projection image is taken and the radiation detector, while preserving pixel values of the projection images, to obtain a plurality of slice plane projection images. A positional misalignment correcting unit corrects positional misalignment between the slice plane projection images. A pixel value calculating unit generates a tomographic image from the slice plane projection images having been subjected to the correction of the positional misalignment.

Claims

1. A tomographic image generation device comprising:

an image obtaining unit for obtaining a plurality of projection images corresponding to different radiation source positions, the projection images being taken by moving a radiation source relative to a detecting unit and applying radiation to a subject from the different radiation source positions to which the radiation source is moved;

a pixel value projecting unit for projecting pixel values of the projection images on coordinate positions on a desired slice plane of the subject based on a positional relationship between the radiation source position with which each of the projection images is taken and the detecting unit, while preserving the pixel values of the projection images, to obtain slice plane projection images corresponding to the individual projection images;

a positional misalignment correcting unit for correcting positional misalignment between the slice plane projection images; and

a pixel value calculating unit for calculating a pixel value of each coordinate position of interest on the slice plane from the slice plane projection images having been subjected to the correction of the positional misalignment to thereby generate a tomographic image of the slice plane.

2. The tomographic image generating device as claimed in claim 1, wherein

the pixel value calculating unit generates an uncorrected tomographic image based on the slice plane projection images before the correction of the positional misalignment, and

the positional misalignment correcting unit detects positional misalignment between the uncorrected tomographic image and each of the slice plane projection images, and corrects positional misalignment between the slice plane projection images based on the detected positional misalignment.

3. The tomographic image generating device as claimed in claim 2, wherein

the positional misalignment correcting unit detects new positional misalignment between a tomographic image generated from the slice plane projection images having been subjected to the correction of the positional misalignment and each of the slice plane projection images having been subjected to the correction of the positional misalignment, and corrects positional misalignment between the slice plane projection images based on the detected new positional misalignment, and

the pixel value calculating unit generates a new tomographic image from the slice plane projection images having been subjected to the correction of the new positional misalignment.

4. The tomographic image generating device as claimed in claim 3, wherein the positional misalignment correcting unit and the pixel value calculating unit repeat the operations of detecting new positional misalignment based on the new tomographic image, correcting positional misalignment between the slice plane projection images based on the detected new positional misalignment, and generating a new tomographic image from the slice plane projection images having been subjected to the correction of the new positional misalignment, until the new positional misalignment converges.

5. The tomographic image generating device as claimed in claim 1, wherein the positional misalignment correcting unit detects the positional misalignment for each local area on the slice plane, and corrects the positional misalignment between the slice plane projection images for each local area based on the detected positional misalignment.

6. The tomographic image generating device as claimed in claim 1, wherein the positional misalignment correcting unit detects the positional misalignment for each local area on the slice plane, detects global positional misalignment between the slice plane projection images based on the local positional misalignment, and corrects the positional misalignment between the slice plane projection images based on the global positional misalignment.

7. The tomographic image generating device as claimed in claim 6, wherein the positional misalignment correcting unit detects further positional misalignment for each local area on the slice plane after the correction of the global positional misalignment, and corrects the positional misalignment between the slice plane projection images for each local area based on the further positional misalignment.

8. The tomographic image generating device as claimed in claim 1, wherein the positional misalignment correcting unit corrects the positional misalignment between the slice plane projection images with removing an outlier pixel value among pixel values of the slice plane projection images or weighting the outlier pixel value with a small weight.

9. The tomographic image generation device as claimed in claim 1, wherein the pixel value projecting unit projects, for each of the different radiation source positions, pixel values at coordinate positions on the corresponding projection image intersecting with straight lines that connect the radiation source position and individual pixel positions on the slice plane as pixel values at the pixel positions on the slice plane on the straight lines.

10. The tomographic image generation device as claimed in claim 1, wherein the pixel value projecting unit projects, for each of the different radiation source positions, pixel values at pixel positions on the corresponding projection image on straight lines that connect the radiation source position and the individual pixel positions on the projection image as pixel values at coordinate positions on the slice plane intersecting with the straight lines.

11. The tomographic image generating device as claimed in claim 1, wherein the pixel value calculating unit calculates the pixel value at the coordinate position of interest on the slice plane based on a plurality of pixel values of the projection images having been subjected to the correction of the positional misalignment and projected in a predetermined range relative to the coordinate position of interest on the slice plane, to thereby generate a tomographic image of the slice plane.

12. The tomographic image generating device as claimed in claim 11, wherein the pixel value calculating unit calculates the pixel value at the coordinate position of interest by performing regression analysis on the pixel values of the slice plane projection images having been subjected to the correction of the positional misalignment.

13. The tomographic image generation device as claimed in claim 12, wherein the pixel value calculating unit calculates pixel values at pixel positions on the slice plane by performing the regression analysis to generate a regression surface that represents a tomographic image of the slice plane, and sampling the regression surface at a desired sampling interval to thereby generate the tomographic image.

14. The tomographic image generation device as claimed in claim 13, wherein the sampling interval is different from a sampling interval of the projection images.

15. The tomographic image generation device as claimed in claim 13, wherein, if an instruction to change the size of an area of interest in the tomographic image being displayed is received, the pixel value calculating unit generates a tomographic image of the area of interest with changing, according to the instruction to change, the sampling interval of an area of the regression surface corresponding to the area of interest.

16. The tomographic image generation device as claimed in claim 12, wherein the pixel value calculating unit changes sharpness of the pixel value at the coordinate position of interest when the regression analysis is performed.

17. The tomographic image generation device as claimed in claim 16, wherein the pixel value calculating unit changes a level of change of the sharpness depending on information of at least one of imaging conditions under which the projection images are taken and a structure of the subject included in the projection images.

18. The tomographic image generation device as claimed in claim 11, wherein the pixel value calculating unit calculates the pixel value at the coordinate position of interest with removing an outlier pixel value among the pixel values of the projection images projected in the predetermined range relative to the coordinate position of interest or weighting the outlier pixel value with a small weight.

19. The tomographic image generation device as claimed in claim 1, wherein the pixel value projecting unit removes low frequency components of the projection images, and projects pixel values of the projection images from which the low frequency components are removed on coordinate positions on the slice plane.

20. The tomographic image generation device as claimed in claim 1, wherein the pixel value projecting unit corrects, based on a positional relationship between a certain radiation source position and each coordinate position of interest on the projection image corresponding to the certain radiation source position, a coordinate position on the slice plane on which a pixel value at the coordinate position of interest on the projection image is projected such that two-dimensional coordinates of the coordinate position of interest on the projection image agrees with two-dimensional coordinates of the coordinate position on the slice plane on which the pixel value at the coordinate position of interest on the projection image is projected, and projects the pixel values of the projection images on the corrected coordinate positions on the slice plane to obtain the slice plane projection images.

21. The tomographic image generation device as claimed in claim 20, wherein the image obtaining unit obtains a radiographic image of the subject taken by applying the radiation to the subject from the certain radiation source position,

the pixel value calculating unit generates the tomographic image by calculating the pixel value at the coordinate position of interest on the slice plane with the pixel values of the projection images being projected on the corrected coordinate positions, and

the tomographic image generation device further comprises a display unit for displaying the radiographic image and the tomographic image.

22. The tomographic image generation device as claimed in claim 1, wherein the pixel value projecting unit and the pixel value calculating unit generate the tomographic image for each of a plurality of slice planes of the subject, and

the tomographic image generation device further comprises a pseudo image generating unit for generating a pseudo image from the tomographic images.

23. The tomographic image generation device as claimed in claim 1, wherein the pixel value calculating unit calculates weighting factors based on a difference between the pixel value at the coordinate position of interest and a pixel value at a coordinate position of each projection image corresponding to the coordinate position of interest, and calculates the pixel value at the coordinate position of interest again based on the plurality of pixel values of the projection images and the weighting factors to calculate a new pixel value at the coordinate position of interest.

24. The tomographic image generation device as claimed in claim 23, wherein the pixel value calculating unit iterates calculating new weighting factors using the new pixel value at the coordinate position of interest, and calculating a new pixel value at the coordinate position of interest again based on the plurality of pixel values of the projection images and the new weighting factors.

25. A tomographic image generation method comprising the steps of:

obtaining a plurality of projection images corresponding to different radiation source positions, the projection images being taken by moving a radiation source relative to a detecting unit and applying radiation to a subject from the different radiation source positions to which the radiation source is moved;

projecting pixel values of the projection images on coordinate positions on a desired slice plane of the subject based on a positional relationship between the radiation source position with which each of the projection images is taken and the detecting unit, while preserving the pixel values of the projection images, to obtain slice plane projection images corresponding to the individual projection images;

correcting positional misalignment between the slice plane projection images; and

calculating a pixel value of each coordinate position of interest on the slice plane from the slice plane projection images having been subjected to the correction of the positional misalignment to thereby generate a tomographic image of the slice plane.

26. A non-transitory recording medium containing a tomographic image generation program for causing a computer to execute the steps of:

obtaining a plurality of projection images corresponding to different radiation source positions, the projection images being taken by moving a radiation source relative to a detecting unit and applying radiation to a subject from the different radiation source positions to which the radiation source is moved;

projecting pixel values of the projection images on coordinate positions on a desired slice plane of the subject based on a positional relationship between the radiation source position with which each of the projection images is taken and the detecting unit, while preserving the pixel values of the projection images, to obtain slice plane projection images corresponding to the individual projection images;

correcting positional misalignment between the slice plane projection images; and

calculating a pixel value of each coordinate position of interest on the slice plane from the slice plane projection images having been subjected to the correction of the positional misalignment to thereby generate a tomographic image of the slice plane.