IN-SITU FORMING FOAMS FOR EMBOLIZING OR OCCLUDING A CAVITY

• US 20160082144A1
• Filed: 07/28/2015
• Published: 03/24/2016
• Est. Priority Date: 03/15/2013
• Status: Abandoned Application

• Current Assignee: Jennifer Mortensen, Toby Freyman
• Original Assignee: Jennifer Mortensen, Toby Freyman
• Inventors: Freyman, Toby, Mortensen, Jennifer
• Application Number:
  US14/811,021
• Publication Number:
  US 20160082144A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/12136 Balloons
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61F 6/22 implantable in tubes occluding by internal devices A61B17/12022
• CPC Class Codes: A61L 24/0036 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/36 for embolization or occlusion, e.g. vaso-occlusive compositions or devices
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges

Abstract

The present invention provides systems and methods for occluding and/or embolizing a cavity within a patient by delivering a prepolymer material into or onto a cavity and forming an expanding foam within the cavity. The inventions methods are applicable to occluding a variety of cavities, including blood vessels, aneurysms, left arterial appendages, vascular malformations and the like.

Claims

1. A method of at least partially occluding a fallopian tube within a patient, comprising:

delivering a fluid prepolymer material into said fallopian tube, and

forming a foam within said fallopian tube from said fluid prepolymer material.

2. The method of claim 1, wherein the step of delivering said fluid prepolymer material is conducted with a delivery device that comprises a catheter.

3. The method of claim 2, wherein the fluid prepolymer material is delivered into a space between an exterior surface of said catheter and the cavity.

4. The method of claim 1, wherein the foam is formed by the reaction of the fluid prepolymer material in the presence of a water-containing environment to generate a gas.

5. The method of claim 4, wherein the foam is an expanding foam formed by the reaction of the fluid prepolymer material in the presence of a water-containing environment to generate a gas.

6. The method of claim 1, wherein the foam is characterized with an expansion ratio within a range of 1.5-5.0, and the foam is fully cured within 10 minutes after the step of delivering the fluid prepolymer material into the fallopian tube.

7. The method of claim 6, wherein the foam is fully cured within 1 minute.

8. A method of at least partially occluding a fallopian tube within a patient, comprising:

delivering a fluid prepolymer material into said fallopian, thereby forming a coiled foam in the fallopian tube.

9. The method of claim 8, wherein the fluid prepolymer is delivered through a catheter configured to expose the fluid prepolymer material to a water-containing environment in a non-circumferential fashion, thereby facilitating coiling of the foam.

10. The method of claim 9, wherein the foam is an expanding foam formed by the reaction of the fluid prepolymer material in the presence of the water-containing environment to generate a gas.

11. The method of claim 9, wherein the fluid prepolymer material is delivered into a space between the exterior surface of the catheter and the cavity.

12. The method of claim 9, wherein the foam is characterized with an expansion ratio within a range of 1.5-5.0, and the foam is fully cured within 10 minutes after the step of delivering the fluid prepolymer material into the fallopian tube.

13. The method of claim 8, wherein the form is fully cured within 1 minute.

14. A method of at least partially occluding a fallopian tube within a patient, comprising:

delivering a balloon into said fallopian tube, wherein said balloon is at least partially filled with a fluid prepolymer material; and

forming a foam within said balloon from said fluid prepolymer material.

15. The method of claim 14, wherein the step of delivering said balloon is conducted with a delivery device that comprises a catheter.

16. The method of claim 14, wherein the foam expands within the balloon to at least partially occlude a portion of the fallopian tube.

17. The method of claim 14, wherein the balloon is a semi-compliant balloon.

18. The method of claim 14, wherein the balloon is a compliant balloon.

19. The method of claim 14, wherein the balloon is non-porous.

20. The method of claim 14, wherein the balloon is semi-porous.