WEARABLE HEMOPERFUSION DEVICE

• US 20160082177A1
• Filed: 09/21/2015
• Published: 03/24/2016
• Est. Priority Date: 09/22/2014
• Status: Active Grant

• Current Assignee: ExThera Medical Corporation
• Original Assignee: ExThera Medical Corporation
• Inventors: WARD, ROBERT S., McCREA, KEITH R.
• Granted Patent: US 10,857,283 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3659 Cannulae pertaining to extracorporeal circulation
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2209/088 on the body
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/226 the blood flow through the rotating member having mainly radial components
• CPC Class Codes: A61M 60/232 Centrifugal pumps
• CPC Class Codes: A61M 60/37 Haemodialysis, haemofiltration or diafiltration
• CPC Class Codes: A61M 60/847 arranged in a cassette
• CPC Class Codes: B01D 15/08 Selective adsorption, e.g. chromatography
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.

Claims

1. A portable and/or wearable device for extracorporeal removal of a toxin and/or pathogen from blood of an individual infected with the toxin and/or pathogen, the device comprising a cartridge, said cartridge comprising an adsorption media,

wherein the adsorption media is a solid substrate of high surface area having at least one polysaccharide adsorbent on the surface thereof with a binding affinity or binding site for the toxin and/or pathogen such that when the flowing blood is in contact with said adsorption media, the toxin and/or pathogen bind to binding sites on the at least one polysaccharide adsorbent and become separated from blood.

8. The portable and/or wearable device of claim 1, wherein the least one polysaccharide adsorbent is selected from the group consisting of heparin, heparan sulfate, hyaluronic acid, sialic acid, carbohydrates with mannose sequences, chitosan and a combination thereof.

9. The portable and/or wearable device of claim 1, wherein the solid substrate comprises a plurality of rigid polymer beads.

10. The portable and/or wearable device of claim 9, wherein the rigid polymer bead is selected from the group consisting of polyurethane, polymethylmethacrylate, polyethylene or co-polymers of ethylene and other monomers, polyethylene imine, polypropylene, and polyisobutylene.

11. The portable and/or wearable device of claim 1, wherein the solid substrate comprises one or a plurality of hollow fibers.

13. The portable and/or wearable device of claim 1, wherein the device is a blood bag.

2. A portable and/or wearable extracorporeal hemoperfusion device, the device comprising:

a cartridge comprising adsorption media, the cartridge having a first endplate and a second endplate;

a blood influx port to allow blood to flow into the device; and

a blood efflux port to allow blood to flow out of the device, wherein the blood flows through the first endplate through the adsorption media and out the blood efflux port.

3. The portable and/or wearable device of claim 2, further comprising a pump.

4. The portable and/or wearable device of claim 3, wherein the pump is a rotary pump.

5. The portable and/or wearable device of claim 2, further comprising a power source.

6. The portable and/or wearable device of claim 2, further comprising an electronic control module.

7. The portable and/or wearable device of claim 6, wherein the power source or the electronic control module are detachable.

12. The portable and/or wearable device of claim 2, wherein the device is wearable.

14. The portable and/or wearable device of claim 2, wherein the first endplate is porous.

15. The portable and/or wearable device of claim 2, wherein the second endplate is porous.

16. The portable and/or wearable device of claim 2, further comprising a dual lumen catheter adaptable to the blood influx port and the blood efflux port.

17. A ex vivo method of reducing a toxin and/or pathogen in the blood of an individual infected with the toxin and/or pathogen, the method comprising:

a) passing blood from the individual through a device comprising an adsorption media, wherein the adsorption media and toxins and/or pathogens in the blood form an adhering complex;

b) separating the resulting blood from the adhering complex to produce blood with a reduced level of the toxin and/or pathogen; and

c) infusing the blood with the reduced level of the toxin and/or pathogen into the individual.

18. The method of claim 17, wherein the blood is selected from the group consisting of whole blood, serum and plasma.

19. The method of claim 18, wherein the blood is whole blood.

20. The method of claim 17, wherein the adsorption media is a solid substrate of high surface area having at least one polysaccharide adsorbent.

21-31. -31. (canceled)