A Fluid Delivery Device Having An Insertable Prefilled Cartridge

• US 20160082182A1
• Filed: 05/30/2014
• Published: 03/24/2016
• Est. Priority Date: 05/31/2013
• Status: Active Grant

• Current Assignee: Mannkind Corporation
• Original Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Inventors: Gregory, Christopher C., Johnson, Matthew P., Standley, Roberl L.
• Granted Patent: US 10,596,313 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/1426 with means for preventing access to the needle after use
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2005/1585 Needle inserters
• CPC Class Codes: A61M 2005/1623 Details of air intake
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14
• CPC Class Codes: A61M 5/288 by piercing without internal pressure increase A61M5/283 takes precedence

Abstract

A fluid delivery device comprises a housing having a bottom surface configured to be coupled to the skin surface. The fluid delivery device includes a cartridge prefilled with a fluid and configured to be inserted into the housing. The cartridge has a septum configured to be generally perpendicular to the bottom surface when the cartridge is inserted in the housing. The fluid delivery device includes a needle assembly that has a needle that includes a fluid coupling end and a delivery end. The fluid coupling end of the needle is fluidly disengaged from the cartridge in an initial position. The delivery end of the needle extends past the plane of the bottom surface and the fluid coupling end of the needle extends through the septum in a deployed position.

Claims

1. A fluid delivery device comprising:

a housing having a bottom surface configured to be coupled to a skin surface;

a cartridge prefilled with a fluid and configured to be inserted into the housing, the cartridge having a septum configured to be generally perpendicular to the bottom surface when the cartridge is inserted in the housing; and

a needle assembly having a needle including a fluid coupling end and a delivery end, the fluid coupling end of the needle being fluidly disengaged from the cartridge in an initial position, the delivery end of the needle extending past a plane co-planer with the bottom surface in a deployed position and the fluid coupling end of the needle extending through the septum in the deployed position.

2. The fluid delivery device of claim 1, wherein the needle has a central portion extending between the fluid coupling end and the delivery end, the central portion bending around an axis that is parallel with the delivery end of the needle.

3. The fluid delivery device of claim 2, wherein the central portion is helically shaped in the initial position.

4. The fluid delivery device of claim 3, wherein the helical shape of the central portion is at least partially flattened toward the bottom surface when moving between the initial and deployed positions.

5. The fluid delivery device of claim 2, wherein the central portion of the needle loops around a moveable needle core.

6. The fluid delivery device of claim 5, wherein the needle core is coupled to a lock member configured to releasably retain the needle in the initial and deployed positions.

7. The fluid delivery device of claim 6, wherein the lock member is rotatable about the needle core and the rotational position of the lock member relative to the needle core determines if the needle is retained in or releasable from the initial and deployed positions.

8. The fluid delivery device of claim 6, wherein the lock member is configured to retain the needle in a locked position after the deployed position, the lock member preventing re-deployment of the needle in the locked position.

9. The fluid delivery device of claim 1, wherein the housing includes a hydraulic fluid drive, which includes hydraulic fluid.

10. The fluid delivery device of claim 9, wherein the hydraulic fluid drive includes a port configured to couple with the cartridge, the port having a seal that is closed prior to inserting the cartridge into the housing and released when the cartridge is coupled with the port, the cartridge including a piston moveable by the hydraulic fluid in the deployed position.

11. The fluid delivery device of claim 10, wherein the seal includes a rotatable valve having one or more fluid passages configured to fluidly couple the hydraulic fluid drive and the piston.

12. The fluid delivery device of claim 10, wherein the seal includes a slideable valve having one or more fluid passages configured to fluidly couple the hydraulic fluid drive and the piston.

13. The fluid delivery device of claim 11, wherein the one or more fluid passages are filled with a fluid prior to the cartridge being inserted into the housing.

14. The fluid delivery device of claim 10, wherein the hydraulic fluid drive is fluidly coupled to an accumulator configured to allow thermal expansion and contraction of the hydraulic fluid.

15. The fluid delivery device of claim 14, wherein the accumulator is fluidly coupled to the hydraulic fluid drive when the seal is closed and fluidly disengaged from the hydraulic fluid drive when the seal is released.

16. The fluid delivery device of claim 9, wherein the hydraulic fluid drive includes a first hydraulic chamber and a second hydraulic chamber, the first hydraulic chamber being fluidly coupled to the second hydraulic chamber by a flow restrictor.

17. The fluid delivery device of claim 1, wherein the needle assembly includes a button, wherein actuation of the button moves the needle from the initial position to the deployed position.

18. The fluid delivery device of claim 17, wherein the button is configured to be actuated by pressing the button toward the bottom surface.

19. The fluid delivery device of claim 1, wherein the needle assembly is coupled to the cartridge and is configured to be inserted into the housing when the cartridge is inserted into the housing.

21. The fluid delivery device of claim 1, wherein a central portion of the needle is purposely deformed while moving from the initial position to the deployed position.

22. The fluid delivery device of claim 1, wherein a central portion of the needle is purposely deformed while moving from the deployed position to a final position, the delivery end of the needle being retained within the housing in the final position.

23. The fluid delivery device of claim 1, wherein the fluid coupling end of the needle and the delivery end of the needle extend in generally perpendicular directions in the deployed position.

20. (canceled)

24. A cartridge assembly for use with a fluid delivery device having a housing, the cartridge assembly comprising:

a cartridge having a septum configured to be generally perpendicular to a bottom surface of the housing when the cartridge is inserted in the housing; and

a needle assembly coupled to the cartridge proximate the septum prior to the cartridge assembly being inserted into the housing, the needle assembly having a needle including a fluid coupling end and a delivery end, the fluid coupling end of the needle being generally perpendicular to the delivery end of the needle, the fluid coupling end of the needle being fluidly disengaged from the cartridge in an initial position, the delivery end of the needle configured to extend past a plane co-planer with the bottom surface in a deployed position and the fluid coupling end of the needle configured to extend through the septum in the deployed position.

25. The fluid delivery device of claim 24, wherein the needle has a central portion extending between the fluid coupling end and the delivery end, the central portion bending around an axis that is parallel with the delivery end of the needle.

26. The fluid delivery device of claim 25, wherein the central portion is helically shaped in the initial position.

27. The fluid delivery device of claim 26, wherein the helical shape of the central portion is at least partially flattened toward the bottom surface when moving between the initial and deployed positions.

28. The fluid delivery device of claim 25, wherein the central section of the needle loops around a moveable needle core.

29. The fluid delivery device of claim 24, wherein the needle assembly is coupled to a lock member and an assembly body, the lock member configured to releasably retain the needle within the assembly body in the initial position and a final position.

30. The fluid delivery device of claim 24, wherein the needle assembly includes a button, wherein actuation of the needle button moves the needle from the initial position to the deployed position.

31. The fluid delivery device of claim 24, wherein a central portion of the needle is purposely deformed while moving from the initial position to the deployed position.

32. The fluid delivery device of claim 24, wherein a central portion of the needle is purposely deformed while moving from the deployed position to a final position, the delivery end of the needle being retained within the housing in the final position.

33. The fluid delivery device of claim 24, wherein the fluid coupling end of the needle and the delivery end of the needle extend in generally perpendicular directions in the deployed position.