Method of setting the blood flow through the bloodstream of a live being and device for an indicator application

• US 20160089035A1
• Filed: 02/11/2015
• Published: 03/31/2016
• Est. Priority Date: 09/25/2014
• Status: Abandoned Application

• Current Assignee: Vsb - Technicka Univerzita Ostrava
• Original Assignee: Vsb - Technicka Univerzita Ostrava
• Inventors: Jurek, Frantisek, Augustynek, Martin, Penhaker, Marek, Ozana, Stepn
• Application Number:
  US14/619,531
• Publication Number:
  US 20160089035A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

Blood flow rate in the bloodstream of a live being is measured using glucose as an indicator continuously supplied to the bloodstream. A reference sample is taken in a selected of measured segment of the bloodstream and then, an indicator of known concentration and known flow is added to the bloodstream, while—with a time delay—there is performed the taking of at least one blood sample from a measuring point, located downstream, while the resulting flow rate through the measured segment is set on the basis of a functional relationship.

Claims

1. A method of estimating a blood flow in a bloodstream in a live being body using glucose as an indicator continuously supplied to the bloodstream, the method comprising:

taking a reference sample in a selected location of a measured segment of the bloodstream;

thereafter, adding an indicator of known concentration (Gi) and known flow (q) to the bloodstream;

after some time interval, taking at least one blood sample from a downstream measuring location; and

arriving at an estimate of the resulting flow through the measured segment according to the following formula

2. The method of claim 1, characterised in that the taking of blood samples is performed in a time delay for a time of indicator mixing with the blood.

3. The method of claim 1, characterised in that the resulting flow through a measured segment of a right atrium of a pulmonary artery is estimated based on the relation

C(s)=A·

C(s)+C₀(s)

4. The method of claim 2, characterised in that a resulting flow through a measured segment of a right atrium of a pulmonary artery is estimated based on the relation

C(s)=A·

C(s)+C₀(s)

5. The method of estimating the blood flow in the bloodstream in a live being body using glucose as an indicator according to claim 1, characterised in that that samples taking and setting the glucose concentration in blood is performed intra-corporally or extra-corporally.

6. The method of estimating the blood flow in the bloodstream in a live being body using glucose as an indicator according to claim 2, characterised in that that samples taking and setting the glucose concentration in blood is performed intra-corporally or extra-corporally.

7. The method of estimating the blood flow in the bloodstream in a live being body using glucose as an indicator according to claim 3, characterised in that that samples taking and setting the glucose concentration in blood is performed intra-corporally or extra-corporally.

8. A device for performing the method of estimating the blood flow in the bloodstream in a live being body using glucose as an indicator according to claim 1, characterised in that that it includes a reservoir (8) of an indicator (1) connected to a linear pump (2) connected with an applicator (9) introduced to the bloodstream (3) to which is connected a drawing means (4) of glucose, connected to a device (5) for setting the concentration of glucose and consequently in an assessment unit (6).