COMPOSITIONS AND METHODS FOR REDUCING CUTANEOUS MICROBIOME MALODOR

• US 20160089315A1
• Filed: 09/29/2015
• Published: 03/31/2016
• Est. Priority Date: 09/29/2014
• Status: Active Grant

• Current Assignee: The Research Foundation for The State University of New York (State University of New York)
• Original Assignee: The Research Foundation for The State University of New York (State University of New York)
• Inventors: Kleinberg, Israel, Zhang, Zegong
• Granted Patent: US 9,555,057 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/592 Mixtures of compounds complementing their respective functions
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/183 Amino acids, e.g. glycine, EDTA or aspartame
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/44 Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

A deodorant composition comprising arginine, bicarbonate, zinc and carbonate, preferably arginine bicarbonate and zinc carbonate (ABZC), and one or more physiologically acceptable excipients, administered for the modification of cutaneous microfloras—generally to reduce axillary odor, promote the growth of Staphylococcus epidermidis bacteria, inhibit the growth of Corynebacterium striatum bacteria, or any or all of the preceding.

Claims

1. A deodorant composition, comprising:

a. arginine, or a salt thereof;

b. a zinc salt;

c. optionally, a buffer sufficient to maintain the pH of said composition at 6.0 or greater upon topical application; and

d. a physiologically-acceptable carrier suitable for topical application/

2. The composition of claim 1, further comprising phenylalanine.

3. The composition of claim 1, said composition being capable of inhibiting the growth and/or metabolism of malodor-generating microbiota present in the cutaneous regions of a subpart of the human body.

4. The composition of claim 1, said composition being capable of inhibiting the growth and/or metabolism of Corynebacterium striatum to a greater extent than the growth and/or metabolism of Staphylococcus epidermidis.

5. The composition of claim 3, wherein said cutaneous regions comprise the axilla, foot-webs and nasal atrium.

6. The composition of claim 1, wherein said zinc salt is selected from zinc carbonate and zinc bicarbonate.

7. The composition of claim 1, wherein said arginine, or a salt thereof is selected from arginine, arginine carbonate and arginine bicarbonate.

8. The composition of claim 1, wherein said zinc salt is zinc carbonate and said arginine salt is arginine bicarbonate.

9. The composition of claim 3, said composition being capable of inhibiting the generation of hydrogen sulfide by said microbiota.

10. The composition of claim 3, said composition being capable of inhibiting the generation of isovaleric acid by said microbiota.

11. The composition of claim 3, said composition being capable of inhibiting the generation of at least one of acetic acid and propionic acid by said microbiota.

12. The composition of claim 3, said composition being capable of inhibiting the generation of at least one of hydrogen sulfide, acetic acid, propionic acid and isovaleric acid by said microbiota.

13. The composition of claim 1, wherein said composition is provided as a topical formulation selected from the group selected from soap, spray, drop, aerosol, powder, roll-on, lotion, cream, stick, solution, sachet, colloidal suspension, film, patch and ointment.

14. The composition of claim 1, wherein said composition upon topical administration has a pH of at least 6.0.

15. The composition of claim 1, wherein said composition upon topical administration has a pH of at least 7.0.

16. The composition of claim 1, wherein said composition upon topical administration has a pH of at least 8.0.

17. The composition of claim 1, wherein said composition upon topical administration has a pH of at least 9.0.

18. The composition of claim 6, wherein said zinc carbonate is present at a concentration of 10% (w/v) or less.

19. The composition of claim 6, wherein said zinc carbonate is present at a concentration of 5% (w/v) or less.

20. The composition of claim 7, wherein said arginine bicarbonate is present at a concentration of 10% (w/v) or less.

21. The composition of claim 7, wherein said arginine bicarbonate is present at a concentration of 5% (w/v) or less.

22. A composition for altering the bacterial degradation products of perspiration, comprising zinc carbonate and arginine bicarbonate, and a physiologically-acceptable carrier suitable for topical application.

23. A method for inhibiting malodor, comprising topically applying to a cutaneous region of a subject in need thereof, a composition including an arginine salt;

a zinc salt; and

a physiologically-acceptable carrier suitable for topical application.

24. The composition of claim 23, further comprising phenylalanine.