Drug Delivery Device with Means for Disabling Activation of Expelling Mechanism

• US 20160089500A1
• Filed: 05/20/2014
• Published: 03/31/2016
• Est. Priority Date: 05/21/2013
• Status: Abandoned Application

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Soerensen, Morten
• Application Number:
  US14/892,329
• Publication Number:
  US 20160089500A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/2411 from the front
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/582 by tactile feedback
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/31501 Means for blocking or restricting the movement of the rod or piston A61M5/5013 takes precedence
• CPC Class Codes: A61M 5/31528 by means of rotational movements, e.g. screw-thread mechanisms
• CPC Class Codes: A61M 5/31541 Means preventing setting of a dose beyond the amount remaining in the cartridge
• CPC Class Codes: A61M 5/31543 piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
• CPC Class Codes: A61M 5/31553 without axial movement of dose setting member
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/31571 Means preventing accidental administration for automatic syringes A61M5/20
• CPC Class Codes: A61M 5/31583 based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

A drug delivery device has a cartridge holder adapted to receive and hold a cartridge, the cartridge holder having a receiving and a holding state. The device further comprises a drive assembly with a piston rod and a drive spring, setting means allowing a user to set a dose amount to be expelled and strain the drive spring correspondingly, and user actuated release means for releasing the drive spring, wherein the drive assembly spring cannot be released to move the piston rod unless the cartridge holder is in the holding state.

Claims

1. A drug delivery device adapted to receive a cartridge comprising a cylindrical body portion, a distal outlet portion and an axially displaceable piston, the drug delivery device comprising:

a housing,

a cartridge holder adapted to receive and hold a cartridge, having;

a receiving state in which a cartridge can be inserted and received, and

a holding state in which an inserted cartridge is held in an operational position,

an expelling assembly comprising;

a piston rod adapted to engage and axially displace a piston in a loaded cartridge in a distal direction to thereby expel a dose of drug from the cartridge, and

a drive assembly comprising;

drive structure adapted to move the piston rod in the distal direction and comprising a drive spring,

setting structure means allowing a user to simultaneously set a dose amount to be expelled and strain the drive spring correspondingly, and

user actuated release structure means for releasing the drive spring to thereby move the piston rod in the distal direction corresponding to the set dose,

wherein the drive assembly cannot be released to move the piston rod unless the cartridge holder is in the holding state.

2. A drug delivery device as in claim 1, further comprising:

a first blocking member actuatable between an initial blocking position and a released position,

wherein the first blocking member in the blocking position prevents the release structure from being released and/or prevents the drive structure from moving the piston rod.

3. A drug delivery device as in claim 2, wherein the release structure comprises:

a coupling member actuatable between an initial locked position and a released position,

wherein the first blocking member in the blocking position prevents the coupling member from being actuated from the initial locked position to the released position.

4. A drug delivery device as in claim 3, wherein:

the coupling member is moved axially in distal direction when actuated, and

the first blocking member is moved axially in distal direction when actuated, thereby allowing the coupling member to be moved distally to the released position.

5. A drug delivery device as in claim 2, further comprising:

user operated actuation structure actuatable from a loading state to an operational state,

wherein actuation of the actuation structure from the loading state to the operational state results in the cartridge holder being actuated from the receiving state to the holding state, and the first blocking member being actuated from the initial blocking position to the released position.

6. A drug delivery device as in claim 5, wherein the actuation structure is actuatable from the loading state through an intermediate state to the operational state, wherein:

the cartridge holder is actuated from the receiving state to the holding state when the actuation structure is actuated from the loading state to the intermediate state, and

the first blocking member is actuated between the initial blocking position and the released position when the actuation structure is actuated from the intermediate state to the operational state.

7. A drug delivery device as in claim 6, wherein the expelling assembly further comprises a coupling being actuatable between:

a resetting state in which the piston rod can be moved proximally, and

an operational state in which the drive assembly can drive the piston rod distally,

wherein the coupling is actuated from the resetting state to the operational state when the actuation structure is actuated from the intermediate state to the operational state.

8. A drug delivery device as in claim 2, wherein the drive assembly cannot be released to move the piston rod unless a cartridge is mounted.

9. A drug delivery device as in claim 8, further comprising:

a second blocking member actuatable between an initial blocking position and a released position when a cartridge is inserted and held in its operational position,

wherein the second blocking member in the blocking position prevents the release structure from being released and/or prevents the drive structure from moving the piston rod.

10. A drug delivery device as in claim 9, wherein the drive structure comprises:

drive member adapted to be moved by the strained drive spring to thereby move the piston rod in the distal direction,

wherein the second blocking member in the blocking position engages the drive member and prevents it from being moved.

11. A drug delivery device as in claim 10, wherein:

the drive member is adapted to rotate, and

the second blocking member is moved axially when actuated, thereby disengaging the drive member allowing it to be rotated by the strained drive spring to thereby move the piston rod in the distal direction.

12. A drug delivery device as in claim 2, wherein:

the cartridge holder comprises distally arranged holding structure which in the receiving state allows a cartridge to be inserted into the cartridge holder in a proximal direction, and

the holding structure in the holding state prevents a received cartridge from moving distally.

13. A drug delivery device as in claim 2, wherein the drug delivery device is front-loaded, the cartridge holder being adapted to receive a cartridge in a proximal direction.

14. A drug delivery device as in claim 2, wherein the setting structure allows the user to reduce a set dose, the drive spring being unstrained correspondingly.

15. A method of operating a drug delivery device adapted to receive a cartridge comprising a cylindrical body portion, a distal outlet portion and an axially displaceable piston, comprising:

providing a drug delivery device comprising;

a cartridge holder adapted to receive and hold a cartridge,

a drive assembly comprising a piston rod, a drive spring for driving the piston rod in a distal direction, setting structure allowing a user to simultaneously set a dose amount to be expelled and strain the drive spring correspondingly, and user actuated release structure for releasing the drive spring to thereby move the piston rod in the distal direction corresponding to the set dose, and

blocking structure preventing, in a blocking state, the release structure means from being released and/or preventing the drive structure from moving the piston rod,

operating the cartridge holder from;

a receiving state in which a cartridge can be inserted and received and the blocking structure is in a blocking state, to

an operational state in which an inserted cartridge is held in an operational position and the blocking structure is released from the blocking state.