ACCURATE ANALYTE MEASUREMENTS FOR ELECTROCHEMICAL TEST STRIP TO DETERMINE ANALYTE MEASUREMENT TIME BASED ON MEASURED TEMPERATURE, PHYSICAL CHARACTERISTIC AND ESTIMATED ANALYTE VALUE AND THEIR TEMPERATURE COMPENSATED VALUES
First Claim
Patent Images
1. An analyte measurement system comprising:
- a test strip including;
a substrate;
a plurality of electrodes connected to respective electrode connectors; and
an analyte meter including;
a housing;
a test strip port connector configured to connect to the respective electrode connectors of the test strip; and
a microprocessor in electrical communication with the test strip port connector to apply electrical signals or sense electrical signals from the plurality of electrodes during a test sequence,wherein the microprocessor may be configured, during the test sequence, to;
(a) start an analyte test sequence upon deposition of a sample;
(b) apply a signal to the sample to determine a physical characteristic signal representative of the sample;
(c) drive another signal to the sample;
(d) measure at least one output signal from at least one of the electrodes;
(e) measure a temperature of one of the sample, test strip, or meter;
(f) determine a temperature compensated value for the physical characteristic signal based on the measured temperature;
(g) derive an estimated analyte concentration from the at least one output signal at one of a plurality of predetermined time intervals as referenced from the start of the test sequence;
(h) determine a temperature compensated value for the estimated analyte concentration based on the measured temperature;
(i) select an analyte measurement sampling time point or time interval with respect to the start of the test sequence based on (1) the temperature compensated value of the physical characteristic signal and (2) the temperature compensated value of the estimated analyte concentration;
(j) calculate an analyte concentration (GU) based on a magnitude of the output signals at the selected analyte measurement sampling time point or time interval;
(k) apply a temperature compensation to the calculated analyte concentration as a function of the measured temperature and respective alpha and beta parameters (α and
β
) dependent on the respective calculated analyte concentration and measured temperature to obtain a compensated analyte concentration (GF); and
(l) annunciate the compensated analyte concentration(GF).
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Abstract
Various embodiments for a method that allow for a more accurate analyte concentration with a biosensor by determining at least one physical characteristic signal representative of the sample containing the analyte and selecting an analyte measurement sampling time based on measured temperature, physical characteristic and estimated analyte values along with temperature compensations provided for specific parameters used in the test assay.
6 Citations
41 Claims
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1. An analyte measurement system comprising:
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a test strip including; a substrate; a plurality of electrodes connected to respective electrode connectors; and an analyte meter including; a housing; a test strip port connector configured to connect to the respective electrode connectors of the test strip; and a microprocessor in electrical communication with the test strip port connector to apply electrical signals or sense electrical signals from the plurality of electrodes during a test sequence, wherein the microprocessor may be configured, during the test sequence, to; (a) start an analyte test sequence upon deposition of a sample; (b) apply a signal to the sample to determine a physical characteristic signal representative of the sample; (c) drive another signal to the sample; (d) measure at least one output signal from at least one of the electrodes; (e) measure a temperature of one of the sample, test strip, or meter; (f) determine a temperature compensated value for the physical characteristic signal based on the measured temperature; (g) derive an estimated analyte concentration from the at least one output signal at one of a plurality of predetermined time intervals as referenced from the start of the test sequence; (h) determine a temperature compensated value for the estimated analyte concentration based on the measured temperature; (i) select an analyte measurement sampling time point or time interval with respect to the start of the test sequence based on (1) the temperature compensated value of the physical characteristic signal and (2) the temperature compensated value of the estimated analyte concentration; (j) calculate an analyte concentration (GU) based on a magnitude of the output signals at the selected analyte measurement sampling time point or time interval; (k) apply a temperature compensation to the calculated analyte concentration as a function of the measured temperature and respective alpha and beta parameters (α and
β
) dependent on the respective calculated analyte concentration and measured temperature to obtain a compensated analyte concentration (GF); and(l) annunciate the compensated analyte concentration(GF).
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2. An analyte measurement system comprising:
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a test strip including; a substrate; a plurality of electrodes connected to respective electrode connectors; and an analyte meter including; a housing; a test strip port connector configured to connect to the respective electrode connectors of the test strip; and a microprocessor in electrical communication with the test strip port connector to apply electrical signals or sense electrical signals from the plurality of electrodes during a test sequence, wherein the microprocessor is configured, during the test sequence, to; (a) start an analyte test sequence upon deposition of a sample; (b) apply a signal to the sample to determine a physical characteristic signal of the sample; (c) drive another signal to the sample; (d) measure at least one output signal from at least one of the electrodes; (e) measure a temperature of one of the sample, test strip, or meter; (f) derive an estimated analyte concentration from the at least one output signal at one of a plurality of predetermined time intervals as referenced from the start of the test sequence; (g) selecting an analyte measurement sampling time point or time interval with respect to the start of the test sequence based on; (1) the measured temperature, (2) the physical characteristic signal, (3) the estimated analyte concentration; (i) calculate an analyte concentration based on a magnitude of the output signals at the selected analyte measurement sampling time point or time interval; (j) apply a temperature compensation to the calculated analyte concentration as a function of the measured temperature and respective alpha and beta parameters (α and
β
) dependent on the respective calculated analyte concentration and measured temperature to obtain a compensated analyte concentration (GF); and(k) annunciate the compensated analyte concentration.
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3. An analyte measurement system comprising:
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a test strip including; a substrate; a plurality of electrodes connected to respective electrode connectors; and an analyte meter including; a housing; a test strip port connector configured to connect to the respective electrode connectors of the test strip; and a microprocessor in electrical communication with the test strip port connector to apply electrical signals or sense electrical signals from the plurality of electrodes during a test sequence, wherein the microprocessor is configured, during the test sequence, to; (a) start an analyte test sequence upon deposition of a sample; (b) apply a signal to the sample to determine a physical characteristic signal of the sample; (c) drive another signal to the sample; (d) measure at least one output signal from at least one of the electrodes; (e) measure a temperature of one of the sample, test strip, or meter; (f) derive an estimated analyte concentration from the at least one output signal at one of a plurality of predetermined time intervals as referenced from the start of the test sequence; (g) determine whether the measured temperature is in one of a plurality of temperature ranges; (h) select an analyte measurement sampling time based on the estimated analyte concentration and the physical characteristic signal representative of the sample in a selected one of a plurality of temperature ranges; (i) calculate an analyte concentration based on a magnitude of the output signals at the analyte measurement sampling time or time interval from the selected analyte measurement sampling time map; and (j) apply a temperature compensation to the calculated analyte concentration as a function of the measured temperature and respective alpha and beta parameters (α and
β
) dependent on the respective calculated analyte concentration and measured temperature to obtain a compensated analyte concentration (GF); and(k) annunciate the compensated analyte concentration. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A glucose meter comprising:
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a housing; a test strip port connector configured to connect to respective electrical connectors of a biosensor; and means for; (a) applying first and second input signals to a sample deposited on the biosensor during a test sequence; (b) measuring a physical characteristic signal representative of the sample from output signals of one of the first and second input signals; (c) measuring a temperature of one of the biosensor or the meter; (d) deriving an estimated a glucose concentration at one of a plurality of predetermined time intervals as referenced from the start of the test sequence based on the other of the first and second input signals; (e) determining a measurement sampling time based on the measured temperature, physical characteristic signal and the estimated glucose concentration; and (f) calculating a glucose concentration based on the measurement sampling time; (g) compensating the glucose concentration from the calculating step based on respective alpha and beta parameters (α and
β
) dependent on the respective calculated analyte concentration and measured temperature to obtain a compensated analyte concentration (GF); andan annunciator to provide an output of the compensated glucose concentration from said means. - View Dependent Claims (18, 19, 20, 21, 24, 27, 28, 29, 30, 31, 32, 33)
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22. A method of determining an analyte concentration from a fluid sample with a test strip having at least two electrodes and a reagent disposed on at least one of the electrodes, the method comprising:
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depositing a fluid sample on any one of the at least two electrodes to start an analyte test sequence; applying a first signal to the sample to measure a physical characteristic of the sample; driving a second signal to the sample to cause an enzymatic reaction of the analyte and the reagent; estimating an analyte concentration based on a predetermined sampling time point from the start of the test sequence; measuring temperature of at least one of the biosensor or ambient environment; obtaining a look up table from a plurality of look-up table indexed to the measured temperature, each look-up table having different qualitative categories of the estimated analyte and different qualitative categories of the measured or estimated physical characteristic indexed against different sampling time points; selecting a sampling time point from the look-up table obtained in the obtaining step; sampling signal output from the sample at the selected measurement sampling time from the look-up table obtained in the obtaining step; calculating an analyte concentration from measured output signal sampled at said selected measurement sampling time in accordance with an equation of the form; - View Dependent Claims (25, 26, 40)
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23. A method of determining an analyte concentration from a fluid sample, the method comprising:
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depositing a fluid sample on a biosensor to start a test sequence; causing the analyte in the sample to undergo an enzymatic reaction; estimating an analyte concentration in the sample; measuring at least one physical characteristic of the sample; measuring temperature of at least one of the biosensor or ambient environment; obtaining a look up table from a plurality of look-up table indexed to the measured temperature, each look-up table having different qualitative categories of the estimated analyte and different qualitative categories of the measured or estimated physical characteristic indexed against different sampling time points; selecting a sampling time point from the look-up table obtained in the obtaining step; sampling signal output from the sample at the selected measurement sampling time from the look-up table obtained in the obtaining step; calculating an analyte concentration from sampled signals at the selected measurement sampling time; compensating the glucose concentration from the calculating step based on respective alpha and beta parameters (α and
β
) dependent on the respective calculated analyte concentration and measured temperature to obtain a compensated analyte concentration (GF). - View Dependent Claims (34, 35, 36, 37, 38, 39)
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41. A method of determining an analyte concentration from a fluid sample with a test strip having at least two electrodes and a reagent disposed on at least one of the electrodes, the method comprising:
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depositing a fluid sample on the test strip to start a test sequence; causing the analyte in the sample to undergo an enzymatic reaction; estimating an analyte concentration in the sample; measuring a signal representative of at least one physical characteristic of the sample; measuring temperature of at least one of the biosensor or ambient environment; compensating for temperature effects on the signal representative of the physical characteristic; compensating for the temperature effects on the estimated analyte concentration; selecting a sampling time based on the compensated analyte estimate and the temperature compensated signal representative of the physical characteristic, the sampling time being referenced from a start sequence at which to obtain a signal output from the test strip; determining an analyte concentration from the sampling time; compensating for temperature effects on the analyte concentration of the determining step.
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Specification