PROCESSING, MODEL ESTABLISHMENT, AND PREDICATION METHODS OF MULTI-POSITION DIFFUSE SPECTRAL DATA AND PROCESSING APPARATUS

• US 20160091496A1
• Filed: 09/23/2015
• Published: 03/31/2016
• Est. Priority Date: 09/28/2014
• Status: Active Grant

• Current Assignee: Tianjin Sunrise Technologies Development Co., Ltd.
• Original Assignee: Tianjin Sunrise Technologies Development Co., Ltd.
• Inventors: Xu, Kexin, Liu, Jin, Zhang, Wanjie
• Granted Patent: US 10,054,594 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: G01J 3/00 Spectrometry; Spectrophotometry; Monochromators; Measuring colours
• CPC Class Codes: G01J 3/0218 using optical fibers
• CPC Class Codes: G01J 3/28 Investigating the spectrum using colour filters G01J3/51
• CPC Class Codes: G01J 3/4412 Scattering spectrometry particle sizing by light scattering G01N15/0205; optical velocimetry of particles G01P5/20, G01P5/26
• CPC Class Codes: G01N 2021/4747 Concentric bundles
• CPC Class Codes: G01N 21/474 Details of optical heads therefor, e.g. using optical fibres
• CPC Class Codes: G01N 21/49 within a body or fluid
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G02B 6/04 formed by bundles of fibres G02B6/24 takes precedence
• CPC Class Codes: G02B 6/3624 Fibre head, e.g. fibre probe termination optical details of light guide terminations G02B6/241; reshaping of light guides G02B6/2552; optical details of coupling light into or out of fibre end G02B6/262

Abstract

A method of processing spectral data is disclosed and may include the steps of illuminating a medium to detect an inside particular component with light; obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position, wherein the first radial position and the second radial position are selected arbitrarily; and performing differential processing on the first spectral data and the second spectral data.

Claims

1. A method of processing spectral data, comprising the steps of:

illuminating a medium to detect an inside particular component with light;

obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position, wherein the first radial position and the second radial position are selected arbitrarily; and

performing differential processing on the first spectral data and the second spectral data.

2. The method of claim 1,

wherein intensity of diffuse reflection light and diffuse transmission light, which passes through the medium and is detected at the first radial position, varies at a first variation rate with a variation in concentration of the particular component in the medium,

wherein intensity of diffuse reflection light and diffuse transmission light, which passes through the medium and is detected at the second radial position, varies at a second variation rate with the concentration variation of the particular component in the medium, and

wherein the first radial position and the second radial position are selected in such a way that the first variation rate and the second variation rate have different signs.

3. The method of claim 1, further comprising the step of:

determining as a reference position a radial position where intensity of diffuse reflection light and/or diffuse transmission light varies with a variation in concentration of the particular component at a variation rate with a minimal absolute value,

wherein two arbitrary radial positions other than the reference position are selected as the first radial position and the second radial position, respectively.

4. The method of claim 3, wherein a position closer to a light source than the reference position is determined as the first radial position, and a position farther away from the light source than the reference position is determined as the second radial position.

5. The method of claim 4, further comprising the step of:

obtaining a third spectral data at the reference position.

6. The method of claim 2, wherein the first variation rate has a positive sign or a negative sign and the second variation rate is substantially zero.

7. The method of claim 1, wherein the first spectral data and the second spectral data each comprise an intensity variation between light intensity in a case where a concentration of the particular component is a first concentration and light intensity in a case where the concentration of the particular component is a second concentration.

8. The method of claim 7, wherein the step of differential processing comprises:

subtracting the intensity variation at the second radial position weighted by a factor η

from the intensity variation at the first radial position,

wherein the factor η

is a ratio between a light intensity variation of diffuse reflection light and/or diffuse transmission light at the first radial position and that at the second radial position cause by a same interference factor while the concentration of the particular component keeps substantially unchanged.

9. The method of claim 8, wherein the factor η

is calculated from optical parameters of the medium.

10. The method of claim 9, wherein the optical parameters of the medium is obtained by reverse construction of the optical parameters.

11. The method of claim 8, wherein the factor η

is obtained by a plurality of measurements.

12. The method of claim 8, wherein the factor η

is estimated by multiplying a ratio between the light intensity at the first radial position at the first concentration and that at the second radial position at the first concentration with a fixed coefficient.

13. The method of claim 12, wherein the fixed coefficient is estimated based on the first radial position and the second radial position.

14. The method of claim 1, wherein the first spectral data and the second spectral data each include a relative intensity variation between light intensity in a case where concentration of the particular component is a first concentration and light intensity in a case where the concentration of the particular component is a second concentration.

15. An optical fiber probe, comprising:

a first optical fiber bundle configured to transmit an incident light and having an exit end located at substantially a center of a detection end of the optical fiber probe;

a second optical fiber bundle; and

a third optical fiber bundle,

wherein at the detection end, a distance between an end of an optical fiber included in the second optical fiber bundle and the exit end of the first optical fiber bundle is different from that between an end of an optical fiber included in the third optical fiber bundle and the exit end of the first optical fiber bundle.

16. The optical fiber probe of claim 15, wherein the second optical fiber bundle and/or the third optical fiber bundle each comprise a plurality of optical fibers having respective ends arranged substantially in a circle or a ring around and centered at the exit end of the first optical fiber bundle.

17. The optical fiber probe of claim 15, further comprising:

a fourth optical fiber bundle,

wherein the fourth optical fiber bundle has an end arranged around the first optical fiber at the detection end, and

wherein a distance between the end of the fourth optical fiber bundle and the exit end of the first optical fiber bundle is different from that between the end of the second optical fiber bundle and the exit end of the first optical fiber bundle and also from that between the end of the third optical fiber bundle and the exit end of the first optical fiber bundle.

18. The optical fiber probe of claim 17, wherein the fourth optical fiber bundle comprises a plurality of optical fibers having respective ends arranged substantially in a circle or a ring centered at the exit end of the first optical fiber bundle.

19. A method of establishing a prediction model, comprising the steps of:

processing spectral data on a series of media to be detected, comprising the steps of;

illuminating a medium to detect an inside particular component with light;

obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position, wherein the first radial position and the second radial position are selected arbitrarily; and

performing differential processing on the first spectral data and the second spectral data.

wherein each of the series of media contains a background or reference medium with a particular component at a respective known concentration added into the background or reference medium, wherein the reference medium contains the background medium and the particular component at an initial concentration; and

establishing the prediction model based on the respective known concentrations and corresponding processed spectral data.

21. The method of claim 20, wherein the prediction model is established by the method of claim 19.

22. The method of claim 19, wherein the method is used in non-invasive detection of blood glucose concentration.

24. The method of claim 22, wherein the applied light has a wavelength in a range of about 1.0-2.4 μ

m.

20. A concentration prediction method, comprising the steps of:

processing spectral data on a medium to be detected, comprising the steps of;

illuminating the medium to detect an inside particular component with light;

obtaining a first spectral data for the medium at a first radial position and a second spectral data for the medium at a second radial position, wherein the first radial position and the second radial position are selected arbitrarily; and

performing differential processing on the first spectral data and the second spectral data.

wherein the medium contains a background or reference medium with a particular component at a concentration included in the background or reference medium, which concentration is unknown due to concentration change, wherein the reference medium comprises the background medium and the particular component at an initial concentration; and

predicting the concentration of the particular component based on the processed spectral data of the medium to be detected and a prediction model.

23. The method of claim 20, wherein the method is used in non-invasive detection of blood glucose concentration.

25. A processing apparatus, comprising:

a detector configured to detect spectral data of diffuse reflection light and diffuse transmission light from a medium to detect an inside particular component; and

a processor configured to obtain spectral data at a first radial position and a second radial position using the detector and perform differential processing on the detected spectral data, wherein the first radial position and the second radial position are selected arbitrarily.

26. The processing apparatus of claim 25,

wherein intensity of the diffuse reflection light and the diffuse transmission light, which is detected at the first radial position, varies at a first variation rate with a variation in concentration of the particular component in the medium,

wherein intensity of the diffuse reflection light and the diffuse transmission light, which is detected at the second radial position, varies at a second variation rate with a variation in concentration of the particular component in the medium, and

wherein the first radial position and the second radial position are selected in such a way that the first variation rate and the second variation rate have different signs.