ANTI-HER2 ANTIBODIES AND IMMUNOCONJUGATES
First Claim
Patent Images
1. An isolated antibody that binds to HER2, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 15;
(b) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
16;
(c) HVR-H3 comprising the amino acid sequence of SEQ ID NO;
17;
(d) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
12;
(e) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
13; and
(f) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
14.
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Abstract
The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.
7 Citations
76 Claims
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1. An isolated antibody that binds to HER2, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 15;
(b) HVR-H2 comprising the amino acid sequence of SEQ ID NO;
16;
(c) HVR-H3 comprising the amino acid sequence of SEQ ID NO;
17;
(d) HVR-L1 comprising the amino acid sequence of SEQ ID NO;
12;
(e) HVR-L2 comprising the amino acid sequence of SEQ ID NO;
13; and
(f) HVR-L3 comprising the amino acid sequence of SEQ ID NO;
14. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
- 15;
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15. An isolated antibody that binds to HER2, wherein the antibody comprises a heavy chain comprising the sequence of SEQ ID NO:
- 19 and a light chain comprising the sequence of SEQ ID NO;
23.
- 19 and a light chain comprising the sequence of SEQ ID NO;
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16. An isolated antibody that binds to HER2, wherein the antibody comprises a heavy chain comprising the sequence of SEQ ID NO:
- 24 and a light chain comprising the sequence of SEQ ID NO;
18.
- 24 and a light chain comprising the sequence of SEQ ID NO;
Specification