SIGNAL DETECTION METHOD, CALIBRATION CURVE CREATION METHOD, QUANTIFICATION METHOD, SIGNAL DETECTION DEVICE, MEASURING DEVICE, AND GLUCOSE CONCENTRATION MEASURING DEVICE

• US 20160097712A1
• Filed: 10/02/2015
• Published: 04/07/2016
• Est. Priority Date: 10/07/2014
• Status: Abandoned Application

• Current Assignee: Seiko Epson Corporation (Seiko Group)
• Original Assignee: Seiko Epson Corporation (Seiko Group)
• Inventors: SHIMIZU, Sakiko, NISHIDA, Kazuhiro
• Application Number:
  US14/873,513
• Publication Number:
  US 20160097712A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/7235 Details of waveform analysis A61B5/349 takes precedence
• CPC Class Codes: G01N 21/274 Calibration, base line adjustment, drift correction
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 2201/12746 Calibration values determination
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80

Abstract

A signal detection method includes acquiring a measurement signal including a first signal, which is a signal of a target component, and a second signal, which is a signal of an interference component; and performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal.

Claims

1. A signal detection method comprising:

acquiring a measurement signal, wherein the measurement signal includes a first signal and a second signal different from the first signal; and

performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal.

2. The signal detection method according to claim 1 wherein:

the orthogonal operation utilizes a second feature signal obtained by performing a multivariate analysis process of a second sample signal, and

the second sample signal is obtained by measuring a sample that contains a component relevant to the second signal and does not contain a component relevant to the first signal.

3. The signal detection method according to claim 2 wherein the multivariate analysis process is an independent component analysis.

4. The signal detection method according to claim 2 wherein the orthogonal operation includes a projection operation that projects the measurement signal to a first space orthogonal to a second space defined by the second feature signal.

5. The signal detection method according to claim 4 wherein, with the measurement signal provided as a measurement vector M, the first signal provided as a first vector M₀, the second feature signal provided as γ

interference unit vectors P_k, the space extended by the second feature signal provided as a matrix P including the interference unit vectors P_k, a pseudo-inverse matrix of the matrix P provided as P⁺, and a unit matrix provided as E, the projection operation is expressed by the following equation;

{right arrow over (M₀)}=(E−

P·

P⁺){right arrow over (M)}.

6. The signal detection method according to claim 2 wherein the orthogonal operation includes an orthogonalization method of Gram-Schmidt that uses the second feature signal.

7. The signal detection method according to claim 6 wherein, with the measurement signal provided as a measurement vector M, the first signal provided as a first vector M₀, the second feature signal provided as γ

interference unit vectors P_k, γ

intermediate vectors provided as W_k, and transposed vectors of the intermediate vectors W_k provided as W_k^T, the orthogonalization method of Gram-Schmidt is provided by the following equations with a first intermediate vector W₁ as a first interference unit vector P₁;

8. The signal detection method according to claim 1 wherein a percentage of the first signal in the measurement signal is equal to or less than 1%.

9. The signal detection method according to claim 1 wherein a percentage of the second signal in the measurement signal is equal to or greater than 3%.

10. The signal detection method according to claim 1 wherein the second signal includes spectrum data of water.

11. The signal detection method according to claim 10 wherein the spectrum data includes spectrum data at a plurality of different temperatures.

12. A calibration curve creation method comprising:

acquiring a measurement signal for a reference sample, wherein the measurement signal includes a first signal and a second signal different from the first signal, and the reference sample has a predetermined physical quantity relevant to the first signal;

performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal;

determining the first signal based on the orthogonal operation of the measurement signal;

calculating an inner product value between the first signal and a unit signal of the first signal; and

generating a calibration curve, wherein the calibration curve associates a physical quantity relevant to the first signal with the inner product value.

13. A quantification method comprising:

acquiring a measurement signal, wherein the measurement signal includes a first signal and a second signal different from the first signal;

performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal; and

calculating an inner product value between the first signal and a unit signal of the first signal, wherein the first signal is based on the orthogonal operation of the measurement signal.

14. The quantification method according to claim 13, further comprising:

quantifying a physical quantity with reference to the inner product value and a calibration curve.

15. The quantification method according to claim 14 further comprising:

generating the calibration curve, wherein the generation of the calibration curve further includes;

acquiring a measurement signal for a reference sample, wherein the measurement signal includes a first signal and a second signal different from the first signal, and the reference sample has a predetermined physical quantity relevant to the first signal;

performing an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal;

determining the first signal based on the orthogonal operation of the measurement signal;

calculating an inner product value between the first signal and a unit signal of the first signal, wherein the calibration curve associates a respective physical quantity relevant to the first signal with a respective inner product value.

16. The quantification method according to claim 14 wherein the physical quantity is glucose concentration in blood.

17. A signal detection device comprising:

an acquisition unit that acquires a measurement signal, wherein the acquisition unit measures a measurement target containing a component relevant to a first signal and a component relevant to a second signal different from the first signal; and

an arithmetic processing unit that performs an orthogonal operation, wherein the orthogonal operation adjusts the measurement signal such that the measurement signal is orthogonal to the second signal.

19. A glucose concentration measuring device comprising the signal detection device according to claim 17.

18. A measuring device comprising:

an acquisition unit that acquires a measurement signal, wherein the acquisition unit measures a measurement target containing a component relevant to a first signal and a component relevant to a second signal different from the first signal; and

an arithmetic processing unit that performs an orthogonal operation for adjusting the measurement signal such that the measurement signal is orthogonal to the second signal, wherein the arithmetic processing unit quantifies a physical quantity using a result of the orthogonal operation.

20. A glucose concentration measuring device comprising the measuring device according to claim 18.