Saliva Glucose Monitoring System
First Claim
1. A glucose analysis system comprising:
- (a) a glucose sensor comprising;
(i) an insulating or semiconducting substrate;
(ii) a working electrode, and(iii) a sample placement area on a surface of the substrate for containing a liquid sample during a determination of a glucose concentration in the liquid sample;
wherein the working electrode is coated with a plurality of sensor elements;
the sensor elements functionalized with a functionalization coating comprising glucose oxidase;
wherein the sensor measures electron transfer through the glucose oxidase into the working electrode; and
wherein an electrical signal of the sensor correlates with the glucose concentration in the liquid sample deposited in the sample placement area; and
(b) a signal conditioning and/or analysis device that processes the electrical signal from the sensor.
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Accused Products
Abstract
A glucose sensor suitable for measuring glucose levels in human saliva is provided. Systems containing the glucose sensor and methods for making and using the sensor are also provided. The glucose sensor is highly sensitive and can detect glucose levels at least down to 5 ppm. Fabrication of the sensor involves depositing single-walled carbon nanotubes onto the surface of a working electrode in a 3 electrode electrochemical detector and functionalizing the nanotubes by depositing layers of polymers, metallic nanoparticles, and glucose oxidase enzyme onto the nanotubes. The sensor can be used as a disposable, single-use device or as part of an analytical system, such as a microfluidics system, for the analysis of multiple analytes. The sensor enables the diagnosis and monitoring of diabetes to be performed without pain or the need for finger pricks in a home or clinical setting.
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Citations
40 Claims
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1. A glucose analysis system comprising:
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(a) a glucose sensor comprising; (i) an insulating or semiconducting substrate; (ii) a working electrode, and (iii) a sample placement area on a surface of the substrate for containing a liquid sample during a determination of a glucose concentration in the liquid sample; wherein the working electrode is coated with a plurality of sensor elements;
the sensor elements functionalized with a functionalization coating comprising glucose oxidase;wherein the sensor measures electron transfer through the glucose oxidase into the working electrode; and
wherein an electrical signal of the sensor correlates with the glucose concentration in the liquid sample deposited in the sample placement area; and(b) a signal conditioning and/or analysis device that processes the electrical signal from the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A glucose sensor array comprising a plurality of glucose sensors comprising:
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(a) an insulating or semiconducting substrate; (b) at least one working electrode, a counter electrode, and a reference electrode, (c) a sample placement area on a surface of the substrate for containing the liquid sample during a determination of the glucose concentration in the liquid sample; and (d) a working electrode coated with a plurality of sensor elements;
the sensor elements functionalized with a functionalization coating comprising glucose oxidase.wherein the sensor measures electron transfer through the glucose oxidase into the working electrode;
wherein an electrical signal of the sensor correlates with a glucose concentration in the liquid sample deposited in the sample placement area; and
wherein the plurality of glucose sensors share a common substrate.- View Dependent Claims (40)
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Specification