BLOOD FILTRATION SYSTEM CONTAINING MANNOSE COATED SUBSTRATE

• US 20160101229A1
• Filed: 12/17/2015
• Published: 04/14/2016
• Est. Priority Date: 06/24/2013
• Status: Abandoned Application

• Current Assignee: ExThera Medical Corporation
• Original Assignee: ExThera Medical Corporation
• Inventors: MCCREA, KEITH, LARM, OLLE, WARD, ROBERT, ADOLFSSON, LARS
• Application Number:
  US14/973,617
• Publication Number:
  US 20160101229A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 1/34 Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3673 Anticoagulant coating, e.g. Heparin coating
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 2202/203 Bacteria
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/7518 bacterial
• CPC Class Codes: B01D 39/04 Organic material, e.g. cellulose, cotton
• CPC Class Codes: B01D 39/083 of organic material
• CPC Class Codes: B01D 39/1615 of natural origin
• CPC Class Codes: B01D 63/08 Flat membrane modules
• CPC Class Codes: B01D 63/10 Spiral-wound membrane modules
• CPC Class Codes: B01D 65/08 Prevention of membrane fouling or of concentration polarisation
• CPC Class Codes: B01D 71/08 Polysaccharides
• CPC Class Codes: C07H 1/00 Processes for the preparation of sugar derivatives

Abstract

A blood filtration method, system, device and media for removing gram negative bacteria from the blood wherein the media includes a substrate coated with mannose optionally in constitution with substrate coated with heparin.

Claims

1. A blood-filtration medium comprising:

a substrate coated with mannose; and

optionally an anti-coagulation component.

2. The medium of claim 1, wherein said substrate comprises non-porous rigid beads, particles, or packing, reticulated foams, a rigid monolithic bed, woven or nonwoven fabric, yarn or solid or hollow dense, monofilament fibers, a flat film or barrier membrane, a spiral wound cartridge formed from flat film or dense membrane.

3. The medium of claim 1, wherein said mannose is end-point attached to said substrate.

4. The medium of claim 1, wherein said anti-coagulation component is present, and said anti-coagulation component is heparin.

5. The medium of claim 4, wherein said substrate comprises substrate coated with said heparin.

6. The medium of claim 4, wherein said substrate comprises non-porous rigid beads wherein a first portion of said beads is coated with mannose and a second portion of said is coated with heparin.

7. The medium of claim 6, wherein said mannose and said heparin are each end-point attached to said beads.

8. The medium of claim 1, wherein said heparin is heparin sulfate.

9. The medium of claim 1, wherein said mannose is D-mannose.

10. The medium of claim 1, wherein said mannose is a D-mannose polymer.

11. A blood filtration cartridge that comprises a container which comprises the medium of claim 1.

12. A system for filtering blood comprising:

a container comprising a substrate coated with mannose;

optionally an anti-coagulation component; and

an extracorporeal blood filtration device, wherein said container is functionally coupled to the blood filtration device so that when in use the blood flows through the container and contacts said substrate.

13. The system of claim 12, wherein said substrate comprises non-porous rigid beads, particles, or packing, reticulated foams, a rigid monolithic bed, woven or non-woven fabric, yarn or solid or hollow dense monofilament fibers, a flat film or barrier membrane, a spiral wound cartridge formed from flat film or dense membrane.

14. The system of claim 12, wherein said mannose is end-point attached to said substrate.

15. The system of claim 12, wherein is present and said anti-coagulation component is heparin.

16. (canceled)

17. (canceled)

18. (canceled)

19. A method for removing at least one gram negative bacteria from blood comprising:

contacting a sample of blood with a media according to 1.

20. The method of claim 19, wherein the gram negative bacteria is an Enterobacteriaceae.

21. The method of claim 19, wherein the gram negative bacteria is at least one member selected from the group consisting of E. coli, Klebsiella pneumoniae, and P. aeruginosa.

22. A method for attaching a mannose to an amine containing substrate, said method comprising:

contacting an aminated substrate with an aqueous solution containing a mannose to form a Schiff base intermediate; and

contacting the Schiff base with a reducing agent to attach said mannose.

23. The method of claim 22, wherein said mannose is a reducing sugar.

24-34. -34. (canceled)