BLOOD COMPONENT MEASUREMENT DEVICE AND BLOOD COMPONENT MEASUREMENT METHOD

• US 20160108451A1
• Filed: 07/07/2014
• Published: 04/21/2016
• Est. Priority Date: 07/08/2013
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Holdings Co., Ltd.
• Inventors: FUJIWARA, Masaki, YAMAMOTO, Tomohiro
• Granted Patent: US 9,738,916 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: C12Q 1/26 involving oxidoreductase
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

Provided are a blood component measurement device and the like capable of further suppressing the errors in measuring blood components. A first current value that is generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 composing a biosensor 1 is measured, a second current value that is generated when a second voltage is applied to a second electrode pair 23, 24 composing the biosensor 1 is measured, and then the first current and the second current are converted to give a blood component amount. Within a predetermined period after the introduction of blood into the biosensor 1, the first current is measured multiple times and the second current is measured once. A CPU 72 converts a plurality of first current values and the second current value to obtain a plurality of blood component amounts and calculates the blood component amount for the blood introduced into the biosensor 1 from said plurality of blood component amounts.

Claims

1-9. -9. (canceled)

10. A blood component measurement device that measures a blood component amount using a biosensor in which blood is introduced and then a blood component contained in said blood is subjected to oxidation-reduction using an oxidoreductase,

wherein the blood component measurement device includes:

a first current value measure that detects, as a first current value, an oxidation-reduction current that is generated by the oxidation-reduction when a first voltage is applied to a first electrode pair composing the biosensor;

a second current value measure that detects, as a second current value, a current that is generated when a second voltage is applied to a second electrode pair composing the biosensor;

a controller that exerts control so that, over a predetermined period after the introduction of the blood into the biosensor, the first current value measure measures the first current value multiple times, with the first voltage being continuously applied to the first electrode pair, and the second current value measure measures the second current value, with the second voltage being applied;

a converter that converts, to blood component amounts, pairs of any one of a plurality of first current values measured by the first current value measure and the second current value measured by the second current value measure; and

a calculator that calculates the blood component amount for the blood introduced into the biosensor, using a plurality of the blood component amounts converted by the converter.

11. The blood component measurement device according to claim 10, wherein

the blood component measurement device includes a memory that contains recorded data, stored per blood in which the blood component amount is known, including a plurality of the blood component amounts converted from the pairs of current values, and

the calculator compares the recorded data with measured data including a plurality of the blood component amounts converted by the converter and calculates the blood component amount of the blood from which recorded data most approximated to said measured data was obtained, as the blood component amount of the blood introduced into the biosensor.

12. The blood component measurement device according to claim 11, wherein the calculator compares a plurality of blood component amounts converted from arbitrary combinations of the first current value and the second current value selected from the pairs of current values measured as a result of the control exerted by the controller, with recorded data of a plurality of blood component amounts converted from the same combinations as the arbitrary combinations of the first current value and the second current value stored in the memory, and calculates the blood component amount of the blood from which recorded data most approximated was obtained, as the blood component amount of the blood introduced into the biosensor.

13. The blood component measurement device according to claim 10, wherein the blood component measurement device includes:

a memory that contains recorded data, stored per blood in which the blood component amount is known and per ambient temperature, including a plurality of the blood component amounts converted from the pairs of current values, and

a temperature detector that detects the ambient temperature, and

the calculator extracts a plurality of recorded data obtained at a temperature near the ambient temperature detected by the temperature detector, compares said plurality of recorded data thus extracted with measured data including the plurality of the blood component amounts converted by the converter, and calculates the blood component amount of the blood from which recorded data most approximated to said measured data was obtained, as the blood component amount of the blood introduced into the biosensor.

14. A blood component measurement device that measures a blood component amount using a biosensor in which blood is introduced and then a blood component contained in said blood is subjected to oxidation-reduction using an oxidoreductase,

wherein the blood component measurement device includes:

a first current value measure that detects, as a first current value, an oxidation-reduction current that is generated by the oxidation-reduction when a first voltage is applied to a first electrode pair composing the biosensor;

a second current value measure that detects, as a second current value, a current that is generated when a second voltage is applied to a second electrode pair composing the biosensor;

a controller that exerts control so that within a predetermined period after the introduction of the blood into the biosensor, the second current value measure applies the second voltage to the second electrode pair in the form of pulses to measure the second current value multiple times and the first current value measure measures the first current value after the application of the second voltage;

a converter that converts, to blood component amounts, pairs of the first current value measured by the first current value measure and any one of a plurality of second current values measured by the second current value measure; and

a calculator that calculates the blood component amount for the blood introduced into the biosensor, using a plurality of the blood component amounts converted by the converter.

15. The blood component measurement device according to claim 14, wherein

the blood component measurement device includes a memory that contains recorded data, stored per blood in which the blood component amount is known, including a plurality of the blood component amounts converted from the pairs of current values, and

the calculator compares the recorded data with measured data including a plurality of the blood component amounts converted by the converter and calculates the blood component amount of the blood from which recorded data most approximated to said measured data was obtained, as the blood component amount of the blood introduced into the biosensor.

16. The blood component measurement device according to claim 15, wherein the calculator compares a plurality of blood component amounts converted from arbitrary combinations of the first current value and the second current value selected from the pairs of current values measured as a result of the control exerted by the controller, with recorded data of a plurality of blood component amounts converted from the same combinations as the arbitrary combinations of the first current value and the second current value stored in the memory, and calculates the blood component amount of the blood from which recorded data most approximated was obtained, as the blood component amount of the blood introduced into the biosensor.

17. The blood component measurement device according to claim 14, wherein the blood component measurement device includes:

a memory that contains recorded data, stored per blood in which the blood component amount is known and per ambient temperature, including a plurality of the blood component amounts converted from the pairs of current values, and

a temperature detector that detects the ambient temperature, and

the calculator extracts a plurality of recorded data obtained at a temperature near the ambient temperature detected by the temperature detector, compares said plurality of recorded data thus extracted with measured data including the plurality of the blood component amounts converted by the converter, and calculates the blood component amount of the blood from which recorded data most approximated to said measured data was obtained, as the blood component amount of the blood introduced into the biosensor.

18. A blood component measurement method in which a blood component amount is measured using a biosensor in which blood is introduced and then a blood component contained in said blood is subjected to oxidation-reduction using an oxidoreductase,

wherein the blood component measurement method includes:

a first current value measurement step for detecting, as a first current value, an oxidation-reduction current that is generated by the oxidation-reduction when a first voltage is applied to a first electrode pair composing the biosensor;

a second current value measurement step for detecting, as a second current value, a current that is generated when a second voltage is applied to a second electrode pair composing the biosensor;

a conversion step for converting, to blood component amounts, pairs of current values consisting of any one of a plurality of first current values measured in the first current value measurement step and the second current value measured in the second current value measurement step; and

a calculation step for calculating the blood component amount contained in the blood using a plurality of the blood component amounts converted in the conversion step,

in the first current value measurement step, the first current value is measured multiple times over a predetermined period after the introduction of the blood into the biosensor, with the first voltage being continuously applied to the first electrode pair,

in the second current value measurement step, the second current value is measured after the first current measurement step, with the second voltage being applied, and

in the conversion step, a plurality of blood component amounts are obtained from a plurality of first current values measured in the first current value measurement step and the second current value measured in the second current value measurement step.

19. The blood component measurement method according to claim 18, wherein the calculation step includes:

referring to recorded data, stored in a memory per blood in which the blood component amount is known, including a plurality of the blood component amounts converted from the pairs of current values;

comparing the recorded data with measured data including the plurality of the blood component amounts converted in the conversion step; and

calculating the blood component amount of the blood from which recorded data most approximated to said measured data was obtained, as the blood component amount of the blood introduced into the biosensor.

20. The blood component measurement method according to claim 18, wherein the blood component measurement method includes a temperature detection step for detecting ambient temperature, and

the calculation step includes:

referring to recorded data, stored in a memory per blood in which the blood component amount is known and per ambient temperature, including the plurality of the blood component amounts converted from the pairs of current values;

extracting a plurality of recorded data obtained at a temperature near the ambient temperature detected in the temperature detection step;

comparing said plurality of recorded data thus extracted with measured data including a plurality of the blood component amounts converted in the conversion step; and

calculating the blood component amount of the blood from which recorded data most approximated to said measured data was obtained, as the blood component amount of the blood introduced into the biosensor.