Substrate for Surface Enhanced Raman Scattering Spectroscopy and Devices Using Same

• US 20160109369A1
• Filed: 08/11/2014
• Published: 04/21/2016
• Est. Priority Date: 08/23/2013
• Status: Active Grant

• Current Assignee: UKON Craft Science Limited
• Original Assignee: UKON Craft Science
• Inventors: Ukon, Juichiro
• Granted Patent: US 10,359,366 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: G01N 21/658 enhancement Raman, e.g. surface plasmons
• CPC Class Codes: G01N 30/74 Optical detectors measurement of intensity, velocity, spectral content, polarisation, or phase of infrared, visible or ultraviolet light G01J

Abstract

It is problematic to provide a substrate for surface enhanced Raman scattering spectroscopy capable of being incorporated and used as a detector of a flow system such as a liquid chromatographic device, and a surface enhanced Raman scattering spectroscopy device and a liquid chromatographic device using same. The above problem is solved by providing a substrate body, pores formed penetrating said substrate body, and particles arranged on an exposed surface of said substrate body not to close the pores, and by an analyte being passed through said particles in-between and said pores.

Claims

1. A substrate for surface enhanced Raman scattering spectroscopy comprising a substrate body, pores formed penetrating said substrate body, and particles arranged on an exposed surface of said substrate body not to close said pores, wherein

said particles are particles in which an analyte is passed through said particles in-between, and

said pores are pores in which an analyte is passed through.

2. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said pores are pores in which the analyte passed through said particles in-between passes through.

3. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said particles are particles including gold, silver, copper, platinum, ruthenium, rhodium, palladium, iron, cobalt, or nickel.

4. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said particles are particles in which the surface of a core particle is covered by a metal film.

5. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 4, wherein said particles are particles in which the surface of said core particle is covered by the metal film in a cap like form.

6. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 4, wherein said core particle includes silica, alumina, titanium oxide, or polystyrene latex, and

said metal film includes gold, silver, copper, platinum, ruthenium, rhodium, palladium, iron, cobalt, or nickel.

7. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 3, wherein said particles have an average particle diameter of 10 to 200 nm.

8. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 4, wherein said metal film has an average film thickness of 10 to 200 nm.

9. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 4, wherein said core particle has an average particle diameter of submicron.

10. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 4, wherein said metal film has an average maximum film thickness of 10 to 200 nm.

11. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said particles are particles in which scattered metal particles are adhered to the surface of a non-conductive core particle.

12. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 11, wherein said metal particles have an average particle diameter of 10 to 100 nm.

13. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 11, wherein said metal particles include gold, silver, copper, platinum, ruthenium, rhodium, palladium, iron, cobalt, or nickel.

14. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein a conductive coating is performed on the surface of said substrate body to externally adjust the potential of said particles.

15. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said substrate body is an inorganic material.

16. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 15, wherein said substrate body includes alumina.

17. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said substrate body is an organic material.

18. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said pores have an average pore diameter smaller than the average particle diameter of said particle and of 5 to 100 nm.

19. The substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1, wherein said particles are particles in which the analyte is vertically passed through said particles in-between.

20. A surface enhanced Raman scattering spectroscopy device, wherein the substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1 is incorporated.

21. A liquid chromatographic device, wherein the substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1 is incorporated.

22. A detector of the liquid chromatographic device, wherein the substrate for surface enhanced Raman scattering spectroscopy as set forth in claim 1 is incorporated.