SYSTEMS AND METHODS FOR HEART VALVE THERAPY
First Claim
1. A prosthetic mitral valve system comprising:
- a valve assembly comprising;
a frame member defining an outer profile and an interior frame member space; and
an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration,wherein the frame member comprises a proximal end frame portion and a distal end frame portion, wherein an outer periphery of the distal end frame portion comprises a generally flat region and a generally round region, and wherein at least some portions of the generally flat region extend distally toward the interior frame member space.
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Accused Products
Abstract
Prosthetic mitral valves described herein can be deployed using a transcatheter mitral valve delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native mitral valve. This document describes prosthetic heart valve designs that interface with native mitral valve structures to create a fluid seal, thereby minimizing mitral regurgitation and paravalvular leaks. This document also describes prosthetic heart valve designs and techniques to manage blood flow through the left ventricular outflow tract. In addition, this document describes prosthetic heart valve designs and techniques that reduce the risk of interference between the prosthetic valves and chordae tendineae.
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Citations
20 Claims
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1. A prosthetic mitral valve system comprising:
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a valve assembly comprising; a frame member defining an outer profile and an interior frame member space; and an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration, wherein the frame member comprises a proximal end frame portion and a distal end frame portion, wherein an outer periphery of the distal end frame portion comprises a generally flat region and a generally round region, and wherein at least some portions of the generally flat region extend distally toward the interior frame member space. - View Dependent Claims (2, 3, 4, 5)
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6. A method of using a prosthetic mitral valve system, comprising:
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advancing a valve assembly of the prosthetic mitral valve system toward an annulus of a native mitral valve, the valve assembly comprising; a frame member defining an outer profile and an interior frame member space; and an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration, wherein the frame member comprises a proximal end frame portion and a distal end frame portion, wherein an outer periphery of the distal end frame portion comprises a generally flat region and a generally round region, and wherein at least some portions of the generally flat region extend toward the interior frame member space; and anchoring the valve assembly at the native mitral valve such that the generally flat region is adjacent to an anterior native leaflet of the native mitral valve. - View Dependent Claims (7, 8, 9, 10)
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11. A prosthetic mitral valve system that is implantable at a native mitral valve, the prosthetic mitral valve system comprising:
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an anchor assembly defining an interior anchor assembly space and a longitudinal axis, the anchor assembly comprising an expandable anchor frame including a hub and a sub-annular support arm extending from the hub, wherein the sub-annular support arm extends to an anchor foot having a surface configured for engagement with a sub-annular gutter of the native mitral valve; and a valve assembly comprising; an expandable valve frame defining an outer profile and an interior frame member space; and an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration, wherein the valve assembly is releasably engageable with the anchor assembly within the interior anchor assembly space, and wherein a distance measured parallel to the longitudinal axis from a distal-most end of the anchor assembly to the surface is at least 14 millimeters. - View Dependent Claims (12)
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13. A method of using a prosthetic mitral valve system, the method comprising:
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advancing an anchor assembly of the prosthetic mitral valve system toward an annulus of a native mitral valve, the anchor assembly defining an interior anchor assembly space and longitudinal axis, the anchor assembly comprising an expandable anchor frame including a hub and one or more sub-annular support arms extending from the hub, wherein each of the one or more sub-annular support arm extends to an anchor foot configured to engage with a sub-annular gutter of the native mitral valve; and engaging the anchor assembly of the prosthetic mitral valve system with tissue proximate the native mitral valve such that a surface of each anchor foot is engaged with the sub-annular gutter, and such that the hub is positioned distal of the distal-most area of coaptation between anterior and post leaflets of the native mitral valve. - View Dependent Claims (14, 15, 16)
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17. A prosthetic mitral valve system comprising:
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an anchor assembly comprising an expandable anchor frame and a set of sub-annular anchor feet configured to engage with a sub-annular gutter of a native mitral valve; and a valve assembly comprising;
an expandable valve frame defining an outer profile and an interior frame member space, a tissue layer disposed over at least a portion of the outer profile, and an occluder mounted within the interior frame member space,wherein an outwardly facing periphery of the tissue layer along the valve assembly is positioned to abut native leaflets of the mitral valve when the set of anchor feet of the anchor assembly is engaged with the sub-annular gutter. - View Dependent Claims (18)
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19. A method of sealing between a prosthetic mitral valve system and native leaflets of a mitral valve, the method comprising:
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anchoring an anchor assembly of the prosthetic mitral valve system with tissue proximate to an annulus of a native mitral valve, the anchor assembly defining an interior anchor assembly space and longitudinal axis, the anchor assembly comprising an expandable anchor frame including a hub and one or more sub-annular support arms extending from the hub, wherein each of the one or more sub-annular support arm extends to an anchor foot that engages with a sub-annular gutter of the native mitral valve; and delivering a valve assembly of the prosthetic mitral valve system to engage with the anchor assembly, the valve assembly comprising;
an expandable valve frame defining an outer profile and an interior frame member space;
a tissue layer disposed over at least a portion of the outer profile; and
an occluder disposed within the interior frame member space, the occluder having an open configuration and a closed configuration,wherein the tissue layer of the valve assembly abuts with native leaflets of the mitral valve while each anchor foot of the anchor assembly is engaged with the sub-annular gutter. - View Dependent Claims (20)
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Specification