SENSING AND ATRIAL-SYNCHRONIZED VENTRICULAR PACING IN AN INTRACARDIAC PACEMAKER

• US 20160114162A1
• Filed: 08/07/2015
• Published: 04/28/2016
• Est. Priority Date: 10/24/2014
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sheldon, Todd J., Demmer, Wade M., Guo, Margaret G.
• Granted Patent: US 9,597,513 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An intracardiac pacemaker is configured to filter a raw cardiac electrical signal received by the pacemaker to produce a filtered cardiac electrical signal, analyzes the filtered cardiac electrical signal to establish cardiac event sensing criteria that discriminate P-waves from T-waves and R-waves all present in the raw cardiac electrical signal, and sense the P-waves from the filtered cardiac electrical signal when the established cardiac event sensing criteria are met. Sensed P-waves may be used for controlling atrial-synchronized ventricular pacing delivered by the pacemaker.

Claims

1. A method performed by a medical device, comprising:

filtering a raw cardiac electrical signal received by the medical device according to first filtering properties to produce a filtered cardiac electrical signal, the raw cardiac electrical signal comprising first cardiac events, second cardiac events different than the first cardiac events, and third cardiac events different than the first cardiac events and the second cardiac events;

detecting a first crossing of a first threshold by the filtered cardiac electrical signal;

identifying one of the second cardiac events after the first crossing;

detecting a second crossing of the first threshold by the filtered cardiac electrical signal after the identified one of the second cardiac events;

analyzing the first crossing and the second crossing of the filtered cardiac electrical signal;

establishing cardiac event sensing criteria that discriminate the first cardiac events from the third cardiac events based on the analyzing of the first crossing and the second crossing; and

sensing the first cardiac events from the filtered cardiac electrical signal when the established cardiac event sensing criteria are met.

2. The method of claim 1, further comprising identifying the one of the second cardiac events in response to one of a delivered cardiac pacing pulse and a crossing of a second threshold by a cardiac electrical signal, the second threshold greater than the first threshold.

3. The method of claim 1, wherein analyzing the first crossing and the second crossing comprises:

setting a sensing window in response to identifying the second cardiac event; and

determining if one of the first crossing and the second crossing occurs within the sensing window.

4. The method of claim 1, wherein analyzing the first crossing and the second crossing of the filtered cardiac electrical signal comprises determining an alternate signal, the alternate signal being at least one of a differential signal of the filtered cardiac electrical signal, a differential signal of the raw cardiac electrical signal, an integrated signal of the filtered cardiac electrical signal, and an integrated signal of the raw cardiac electrical signal;

and

comparing a feature of the alternate signal at a time of the first crossing to a feature of the alternate signal at a time of the second crossing.

5. The method of claim 1, wherein:

analyzing the first crossing and the second crossing of the filtered cardiac electrical signal comprises;

acquiring a first waveform of the filtered cardiac electrical signal corresponding to the first crossing of the first threshold,

acquiring a second waveform of the filtered cardiac electrical signal corresponding to the second crossing of the first threshold, and

comparing the first waveform to the second waveform to verify that the first and second waveforms do not match; and

establishing the cardiac event sensing criteria comprises;

determining a first feature from the first waveform;

determining a second feature from the second waveform, the second feature analogous to the first feature;

determining a difference between the first feature and the second feature; and

establishing the cardiac event sensing criteria by at least setting a cardiac event sensing criterion based on the difference.

6. The method of claim 5, wherein:

analyzing the first crossing and the second crossing comprises;

setting a sensing window in response to identifying the second cardiac event;

determining if the second crossing occurs within the sensing window; and

determining if the first waveform and the second waveform match; and

establishing the cardiac event sensing criteria to include setting the sensing window in response to identified second cardiac events when the second crossing occurs within the sensing window and the first waveform and the second waveform do not match.

7. The method of claim 5, wherein analyzing the first crossing and the second crossing comprises:

determining if the first waveform and the second waveform match;

analyzing an alternate cardiac electrical signal when the first waveform and the second waveform do match, the alternate cardiac electrical signal being one of the raw cardiac electrical signal, an integrated signal of the filtered cardiac electrical signal, and an alternate filtered cardiac electrical signal produced by filtering the raw cardiac electrical signal according to second filtering properties different than the first filtering properties;

identifying the third cardiac event on the alternate cardiac electrical signal;

determining if one of first crossing and the second crossing coincide with the third cardiac event on the alternate cardiac electrical signal; and

adjusting the first filtering properties when one of the first threshold crossing and the next threshold crossing coincide with the third cardiac event of the alternate cardiac electrical signal.

8. The method of claim 5, wherein analyzing the first crossing and the second crossing further comprises:

determining if the first waveform and the second waveform match based on the comparing;

searching for an inflection point along a descending portion of at least one of the first waveform and the second waveform when the first waveform and the second waveform match;

detecting one of the first cardiac events along one of the third cardiac events in the filtered cardiac electrical signal when the inflection point is found along the descending portion; and

establishing the cardiac event sensing criteria in response to finding the inflection point along the descending portion.

9. The method of claim 5, further comprising:

when the first waveform and the second waveform do not match based on the comparing, enabling setting a pacing escape interval upon sensing the first cardiac events according to the established sensing criteria;

controlling a pulse generator to deliver a pacing pulse to a patient'"'"'s heart when the pacing escape interval expires; and

disabling setting the pacing escape interval when the first waveform and the second waveform do match based on the comparing.

10. The method of claim 1, further comprising:

detecting a decreasing time interval between the third cardiac events and the first cardiac events, and

updating the established sensing criteria in response to detecting the decreasing event time interval.

11. The method of claim 1, further comprising:

setting a first pacing escape interval in response to sensing a first sensed event sensed according to the established sensing criteria;

delivering a first pacing pulse upon expiration of the first pacing escape interval;

determining a first time interval from the first pacing pulse to a second sensed event sensed according to the established sensing criteria;

setting a second pacing escape interval in response to sensing a third sensed event sensed according to the established sensing criteria;

delivering a second pacing pulse upon expiration of the second pacing escape interval, the second pacing escape interval shorter than the first pacing escape interval;

determining a second time interval from the second pacing pulse to a fourth sensed event sensed according to the established sensing criteria;

determining if the first time interval matches the second time interval; and

updating the established sensing criteria in response to the first time interval and the second time interval matching.

12. An implantable medical device, comprising:

a sensing module configured to receive a raw cardiac electrical signal via electrodes coupled to the sensing module, the raw cardiac electrical signal comprising first cardiac events, second cardiac events different than the first cardiac events, and third cardiac events different than the first cardiac events and the second cardiac events, the sensing module configured to;

filter the raw cardiac electrical signal according to first filtering properties to produce a filtered cardiac electrical signal;

detect a first crossing of a first threshold by the filtered cardiac electrical signal;

identify one of the second cardiac events after the first crossing;

detect a second crossing of the first threshold by the filtered cardiac electrical signal after the identified one of the second cardiac events;

analyze the first crossing and the second crossing of the filtered cardiac electrical signal;

establish cardiac event sensing criteria that discriminate the first cardiac events from the third cardiac events based on the analyzing of the first crossing and the second crossing; and

sense the first cardiac events from the filtered cardiac electrical signal when the established cardiac event sensing criteria are met.

13. The device of claim 12, further comprising a pulse generator configured to generate and deliver a pacing pulse to a patient'"'"'s heart via electrodes coupled to the pulse generator,

wherein the sensing module is configured to identify the one of the second cardiac events in response to one of a delivered cardiac pacing pulse and a crossing of a second threshold by a cardiac electrical signal, the second threshold greater than the first threshold.

14. The device of claim 12, wherein the sensing module is configured to analyze the first crossing and the second crossing by at least:

setting a sensing window in response to identifying the second cardiac event; and

determining if one of the first crossing and the second crossing occurs within the sensing window.

15. The device of claim 12, wherein the sensing module is configured to analyze the first crossing and the second crossing of the filtered cardiac electrical signal by:

determining an alternate signal, the alternate signal being at least one of a differential signal of the filtered cardiac electrical signal, a differential signal of the raw cardiac electrical signal, an integrated signal of the filtered cardiac electrical signal, and an integrated signal of the raw cardiac electrical signal; and

comparing a feature of the alternate signal at a time of the first crossing to a feature of the alternate signal at a time of the second crossing.

16. The device of claim 12, wherein the sensing module is configured to analyze the first crossing and the second crossing of the filtered cardiac electrical signal by at least:

acquiring a first waveform of the filtered cardiac electrical signal corresponding to the first crossing of the first threshold;

acquiring a second waveform of the filtered cardiac electrical signal corresponding to the second crossing of the first threshold; and

comparing the first waveform to the second waveform.

17. The device of claim 16, wherein the sensing module is further configured to:

analyze the first crossing and the second crossing by;

setting a sensing window in response to identifying the second cardiac event;

determining if the second crossing occurs within the sensing window; and

determining if the first waveform and the second waveform match; and

establishing the cardiac event sensing criteria to include setting the sensing window in response to identified second cardiac events when the second crossing occurs within the sensing window and the first waveform and the second waveform do not match.

18. The device of claim 16, wherein the sensing module is further configured to analyze the first crossing and the second crossing by:

determining if the first waveform and the second waveform match;

analyzing an alternate cardiac electrical signal received by the sensing module via the electrodes coupled to the sensing module when the first waveform and the second waveform do match, the alternate cardiac electrical signal being one of the raw cardiac electrical signal, an integrated signal of the filtered cardiac electrical signal, and an alternate filtered cardiac electrical signal produced by the sensing module by filtering the raw cardiac electrical signal according to second filtering properties different than the first filtering properties;

identifying the third cardiac event on the alternate cardiac electrical signal;

determining if one of first crossing and the second crossing coincide with the third cardiac event on the alternate cardiac electrical signal; and

adjusting the first filtering properties when one of the first threshold crossing and the next threshold crossing coincide with the third cardiac event of the alternate cardiac electrical signal.

19. The device of claim 16, wherein the sensing module is further configured to analyze the first crossing and the second crossing by:

determining if the first waveform and the second waveform match based on the comparing;

searching for an inflection point along a descending portion of at least one of the first waveform and the second waveform when the first waveform and the second waveform match;

detecting one of the first cardiac events along one of the third cardiac events in the filtered cardiac electrical signal when the inflection point is found along the descending portion; and

establishing the cardiac event sensing criteria in response to finding the inflection point along the descending portion.

20. The device of claim 16, further comprising:

a pulse generator configured to generate and deliver a pacing pulse to a patient'"'"'s heart via electrodes coupled to the pulse generator;

a control module coupled to the sensing module and the pulse generator and configured to;

enable setting a pacing escape interval when the first waveform and the second waveform do not match based on the comparing;

set the pacing escape interval upon sensing each one of the first cardiac events according to the established sensing criteria;

control the pulse generator to deliver a pacing pulse to a patient'"'"'s heart when the pacing escape interval expires; and

disable setting the pacing escape interval when the first waveform and the second waveform do match based on the comparing.

21. The device of claim 12, wherein the sensing module is further configured to:

detect a decreasing event time interval between the third cardiac events and the first cardiac events, and

update the established sensing criteria in response to detecting the decreasing event time interval.

22. The device of claim 12, further comprising:

a pulse generator configured to generate and deliver a pacing pulse to a patient'"'"'s heart via electrodes coupled to the pulse generator;

a control module coupled to the sensing module and the pulse generator and configured to;

set a first pacing escape interval in response to a first sensed event sensed by the sensing module according to the established sensing criteria;

control the pulse generator to deliver a first pacing pulse upon expiration of the first pacing escape interval;

determine a first time interval from the first pacing pulse to a second sensed event sensed by the sensing module according to the established sensing criteria;

set a second pacing escape interval in response to a third sensed event sensed by the sensing module according to the established sensing criteria;

delivering a second pacing pulse upon expiration of the second pacing escape interval, the second pacing escape interval shorter than the first pacing escape interval;

determining a second time interval from the second pacing pulse to a fourth sensed event sensed by the sensing module according to the established sensing criteria;

determining if the first time interval matches the second time interval; and

updating the established sensing criteria in response to the first time interval and the second time interval matching.

23. A non-transitory, computer-readable medium storing a set of instructions which, when executed by an implantable medical device cause the device to:

filter a raw cardiac electrical signal received by the medical device according to first filtering properties to produce a filtered cardiac electrical signal, the raw cardiac electrical signal comprising first cardiac events, second cardiac events different than the first cardiac events, and third cardiac events different than the first and second cardiac events;

detect a first crossing of a first threshold by the filtered cardiac electrical signal;

identify one of the second cardiac events after the first crossing;

detect a second crossing of the first threshold by the filtered cardiac electrical signal after the identified one of the second cardiac events;

analyze the first crossing and the second crossing of the filtered cardiac electrical signal;

establish cardiac event sensing criteria that discriminate the first cardiac events from the third cardiac events based on the analyzing of the first crossing and the second crossing; and

sense the first cardiac events from the filtered cardiac electrical signal when the established cardiac event sensing criteria are met.