COMPOSITIONS AND METHODS FOR SPECIFIC REGULATION OF PYRUVATE DEHYDROGENASE KINASE
First Claim
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1. A therapeutic peptide comprising a δ
- PKC-selective modulatory peptide and a carrier peptide,wherein the modulatory peptide comprises a contiguous core sequence of 5 amino acid residues wherein the contiguous core sequence is at least 60% identical to SEQ ID NO;
1; and
wherein the modulatory peptide is linked to the carrier peptide by a peptide bond.
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Abstract
A peptide composition is provided which specifically inhibits the ability of δ-protein kinase C (δPKC) to phosphorylate pyruvate dehydrogenase kinase (PDK) under ischemic conditions. The peptide composition is useful for treating or reducing tissue damage resulting from ischemia and/or reperfusion.
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Citations
15 Claims
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1. A therapeutic peptide comprising a δ
- PKC-selective modulatory peptide and a carrier peptide,
wherein the modulatory peptide comprises a contiguous core sequence of 5 amino acid residues wherein the contiguous core sequence is at least 60% identical to SEQ ID NO;
1; andwherein the modulatory peptide is linked to the carrier peptide by a peptide bond. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- PKC-selective modulatory peptide and a carrier peptide,
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10. A composition comprising a δ
- PKC-selective modulatory peptide linked to a carrier peptide,
wherein the δ
PKC-selective modulatory peptide is 5 to 20 amino acids in length and comprises a contiguous core sequence of 5 amino acid residues, wherein the contiguous core sequence is at least 60% identical to SEQ ID NO;
1. - View Dependent Claims (11, 12, 13, 14, 15)
- PKC-selective modulatory peptide linked to a carrier peptide,
Specification