ANTIBODIES AND OTHER MOLECULES THAT BIND B7-H1 AND PD-1
First Claim
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1. A molecule, comprising an antigen-binding fragment of an antibody that immunospecifically binds to B7-H1 or PD-1.
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Abstract
The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to B7-H1 or PD-1. In some embodiments such molecules are additionally capable of modulating the ability of B7-H1 or B7-DC to bind to PD-1 or are capable of affecting the signaling activity of the B7-H1 or PD-1. The invention additionally concerns the uses of such molecules in the diagnosis and treatment of cancer and other diseases.
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Citations
17 Claims
- 1. A molecule, comprising an antigen-binding fragment of an antibody that immunospecifically binds to B7-H1 or PD-1.
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17-20. -20. (canceled)
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