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CYSTEINE ENGINEERED ANTIBODIES AND CONJUGATES

  • US 20160130358A1
  • Filed: 09/11/2015
  • Published: 05/12/2016
  • Est. Priority Date: 09/12/2014
  • Status: Active Grant
First Claim
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1. A cysteine engineered antibody comprising a cysteine amino acid in the heavy chain selected from the group consisting of T114C, A140C, L174C, L179C, T187C, T209C, V262C, G371C, Y373C, E382C, S424C, N434C and Q438C according to EU numbering, or a cysteine amino acid in the light chain selected from the group consisting of I106C, R108C, R142C, and K149C according to Kabat numbering.

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