Techniques for Predicting Cardiac Arrhythmias Based on Signals from Leads of Electrocardiography

• US 20160135702A1
• Filed: 06/20/2014
• Published: 05/19/2016
• Est. Priority Date: 06/21/2013
• Status: Abandoned Application

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Perez, Marco V.
• Application Number:
  US14/899,901
• Publication Number:
  US 20160135702A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/327 Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads
• CPC Class Codes: A61B 5/33 specially adapted for cooperation with other devices
• CPC Class Codes: A61B 5/353 Detecting P-waves
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/363 Detecting tachycardia or bradycardia
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment

Abstract

Techniques for predicting cardiac arrhythmia includes obtaining first data that indicates an electrocardiography recording from a patient; and, automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording. A value for a first parameter, Pindex3, is determined based on a standard deviation of P-wave duraations automatically derived from only three leads of the plurality of leads. A risk of incidence of cardiac arrhythmia for the patient is determined based, at least in part, on the first parameter, Pindex3.

Claims

1. A method comprising:

obtaining first data that indicates an electrocardiography recording from a patient;

automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording;

determining a value for a first parameter, called Pindex3, based on a standard deviation of P-wave durations automatically derived from only three leads of the plurality of leads;

determining a risk of incidence of cardiac arrhythmia for the patient based, at least in part, on the first parameter, Pindex3; and

presenting on a display device output data that indicates the risk of incidence.

2. A method as recited in claim 1, wherein the only three leads are orthogonal to each other.

3. A method as recited in claim 1, wherein the only three leads consist of lead I, lead aVF and lead V1 of the electrocardiography recording from the patient.

4. A method as recited in claim 1, further comprising treating the patient based on the determined risk of incidence of cardiac arrhythmia.

5. A method as recited in claim 4, wherein:

determining the risk of incidence of cardiac arrhythmia for the patient further comprises determining that the patient is at elevated risk for atrial fibrillation if the value for the first parameter exceeds 45; and

treating the patient further comprises treating the patient to reduce risk of atrial fibrillation if the patient is determined to be at elevated risk for atrial fibrillation.

6. A method as recited in claim 1, wherein:

the method further comprises determining a value for a different second parameter based on P-wave characteristics automatically derived from at least one of the plurality of leads; and

determining the risk of incidence of cardiac arrhythmia for the patient further comprises determining the risk of incidence of cardiac arrhythmia for the patient based at least in part on the second parameter.

7. A method as recited in claim 6, wherein the different second parameter is selected from a group comprising:

abnlPaxis that indicates a first value for an abnormal P-wave axis and a different second value for a normal P-wave axis;

anyPAC that indicates a third value in the presence of a premature atrial contraction (PAC) within a randomly chosen 10-second period and a different fourth value in the absence of the premature atrial contraction (PAC);

PRdurlong that indicate a PR interval greater than 200 miliseconds;

Plongthree that indicates a maximum P-wave duration of greater than 120 ms;

PVCs that indicates a fifth value for a premature ventricular contraction within a randomly chosen 10-second period and a different sixth value for the absence of such a ventricular premature complex; and

LBBB that indicates a seventh value in the presence of a left bundle branch block and a different eighth value in the absence of a left bundle branch block.

8. A method as recited in claim 7, wherein:

the first value is about 1, the second value is about 0, the third value is about 1, the fourth value is about 0, the fifth value is about 1, the sixth value is about 0, the seventh value is aboutl, and the eighth value is about 0;

determining the risk of incidence of cardiac arrhythmia for the patient further comprises determining the risk of incidence of atrial fibrillation for the patient based on a parameter Psummary equal to a sum of products of an age parameter times about 0.068, and a gender parameter times about 1.5, and Pindex3 times about 0.0056, and abnlPaxis times about 0.41, and anyPAC times about 0.74, and PRdurlong times about 0.27, and Plongthree times about 0.57 and PVCs times about 0.45, and LBBB times about 0.64; and

the age parameter indicates a value for an age of the patient in years, and the gender parameter indicates a value of about 1 if the patient is a male patient and about 0 if the patient is a female patient.

9. A method as recited in claim 8, wherein Psummary=(Age parameter*0.06863)+(Gender parameter*1.48060)+(Pindex3*0.00559)+(abnlPpaxis*0.40787)+(anyPAC*0.74221)+(PRdurlong*0.26716)+(Plongthree*0.57023)+(PVCs*0.44873)+(LBBB*0.64420).

10. A method as recited in claim 7, wherein determining the risk of incidence of atrial fibrillation for the patient based on the parameter Psummary further comprises determining that the patient is at least about five times a normal risk for atrial fibrillation if the value for Psummary exceeds about 5.4.

11. A method as recited in claim 7, wherein determining the risk of incidence of atrial fibrillation for the patient based on the parameter Psummary further comprises determining that the patient is at least about eleven times a normal risk for atrial fibrillation if the value for Psummary exceeds about 6.3.

12. A method as recited in claim 1, wherein the cardiac arrhythmia is atrial fibrillation.

13. A method as recited in claim 1, wherein the cardiac arrhythmia is atrial flutter.

14. A non-transitory computer-readable medium carrying one or more sequences of instructions, wherein execution of the one or more sequences of instructions by one or more processors causes an apparatus to perform the steps of:

obtaining first data that indicates an electrocardiography recording from a patient;

automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording;

determining a value for a first parameter, Pindex3, based on a standard deviation of P-wave durations automatically derived from only three leads of the plurality of leads;

determining a risk of incidence of cardiac arrhythmia for the patient based, at least in part, on the first parameter; and

presenting on a display device output data that indicates the risk of incidence.

15. An apparatus comprising:

at least one processor; and

at least one memory including one or more sequences of instructions,

the at least one memory and the one or more sequences of instructions configured to, with the at least one processor, cause the apparatus to perform at least the following, obtaining first data that indicates an electrocardiography recording from a patient;

automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording;

determining a value for a first parameter, Pindex3, based on a standard deviation of P-wave durations automatically derived from only three leads of the plurality of leads;

determining a risk of incidence of cardiac arrhythmia for the patient based, at least in part, on the first parameter; and

presenting on a display device output data that indicates the risk of incidence.

16. A system comprising:

means for obtaining first data that indicates an electrocardiography recording from a patient;

means for automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording;

means for determining a value for a first parameter, Pindex3, based on a standard deviation of P-wave durations automatically derived from only three leads of the plurality of leads;

means for determining a risk of incidence of cardiac arrhythmia for the patient based, at least in part, on the first parameter; and

means for presenting on a display device output data that indicates the risk of incidence.

17. A system comprising:

a display device;

at least one processor; and

at least one memory including one or more sequences of instructions,

the at least one memory and the one or more sequences of instructions configured to, with the at least one processor, cause the apparatus to perform at least the following, obtaining first data that indicates an electrocardiography recording from a patient;

automatically deriving, on a processor, P-wave characteristics on a plurality of leads of the electrocardiography recording;

determining a value for a first parameter, Pindex3, based on a standard deviation of P-wave durations automatically derived from only three leads of the plurality of leads;

determining a risk of incidence of cardiac arrhythmia for the patient based, at least in part, on the first parameter; and

presenting on the display device output data that indicates the risk of incidence.