LENS CARE PRODUCT FOR OZONE-BASED CLEANING/DISINFECTING OF CONTACT LENSES

• US 20160136320A1
• Filed: 06/24/2014
• Published: 05/19/2016
• Est. Priority Date: 06/24/2013
• Status: Abandoned Application

• Current Assignee: Novartis Ag
• Original Assignee: John Dallas Pruitt, Leroy Wainaina Muya, Robert Carey Tucker
• Inventors: TUCKER, Robert Carey, MUYA, Leroy Wainaina, PRUITT, John Dallas
• Application Number:
  US14/898,426
• Publication Number:
  US 20160136320A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61L 12/122 Ozone
• CPC Class Codes: C11D 3/0078 Compositions for cleaning contact lenses, spectacles or lenses
• CPC Class Codes: C11D 3/166 containing borium
• CPC Class Codes: C11D 3/2079 Monocarboxylic acids-salts thereof
• CPC Class Codes: C11D 7/08 Acids
• CPC Class Codes: C11D 7/10 Salts
• CPC Class Codes: C11D 7/265 Carboxylic acids or salts thereof

Abstract

The present invention provides an aqueous lens care solution for disinfecting and/or cleaning contact lenses in an ozone-based lens care system. The lens care solution of the invention is a hypotonic solution, has an osmolality at about 25° C. of from about 200 mOsm/kg to about 260 mOsm/kg, and comprises at least one relatively-ozone-inert buffering agent selected from the group consisting of boric acid, sodium tetraborate, potassium tetraborate, acetic acid, sodium acetate, potassium acetate, and a mixture thereof. The aqueous lens care solution is compatible with ozone electrolytically generated in an ozone-based lens care system as characterized by comprising about 30 mM or less of chloride ion and less than about 10 mM of one or more ozone-interfering buffering agents.

Claims

1. An aqueous lens care solution for disinfecting and/or cleaning contact lenses in an ozone-based lens care system,

having an osmolality at about 25°

C. of from about 150 to about 260 mOsm/kg, preferably from about 170 to about 250 mOsm/kg, more preferably from about 180 to about 240 mOsm/kg, and a conductivity of from about 0.1 mS/cm to about 10 mS/cm, preferably from about 0.5 mS/cm to about 8 mS/cm, more preferably from about 0.5 mS/cm to about 6 mS/cm; and

comprising at least one relatively-ozone-inert buffering agent selected from the group consisting of boric acid, sodium tetraborate, potassium tetraborate, acetic acid, sodium acetate, potassium acetate, and a mixture thereof,

wherein the aqueous lens care solution is compatible with ozone electrolytically generated in an ozone-based lens care system as characterized by comprising (1) about 30.0 mM/L or less, preferably about 4.0 mM/L or less, more preferably about 2.0 mM/L or less, even more preferably about 0.05 mM/L or less, most preferably about 0.03 mM/L or less of chloride ions and (2) about 10 mM or less, preferably 5 mM or less, more preferably 2 mM or less, even more preferably 1 mM or less of one or more ozone-interfering buffering agents.

2. The aqueous lens care solution of claim 1, wherein the aqueous lens care solution has a pH of from about 5.5 to about −

9.0, preferably from about 6.0 to about 8.0, more preferably from about 6.5 to about 7.0.

3. The aqueous lens care solution of claim 1 or 2, wherein the one or more ozone-interfering buffering agents are selected from the group consisting of phosphoric acid, phosphates (referring to Na₂HPO₄, NaH₂PO₄, Na₂HPO₄, KH₂PO₄, (NH₄)₂HPO₄, NH₄H₂PO₄, or a mixture thereof), citric acid, citrates (referring to potassium citrate, sodium citrate, ammonium citrate, or a mixture thereof), bicarbonates (referring to sodium bicarbonate, potassium bicarbonate, ammonium bicarbonate, or a mixture thereof), carbonates (referring to sodium carbonate, potassium carbonate, ammonium carbonate, or a mixture thereof), propionic acid, propionates (referring to potassium propionate, sodium propionate, ammonium propionate, or a mixture thereof) TRIS (2-amino-2-hydroxymethyl-1,3-propanediol) and salts thereof, Bis-Tris (Bis-(2-hydroxyethyl)-imino-tris-(hydroxymethyl)-methane) and salts thereof, bis-aminopolyols and salts thereof, triethanolamine and salts thereof, ACES (N-(2-hydroxyethyl)-2-aminoethanesulfonic acid) and salts thereof, BES (N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid) and salts thereof, HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) and salts thereof, MES (2-(N-morpholino)ethanesulfonic acid) and salts thereof, MOPS (3-[N-morpholino]-propanesulfonic acid) and salts thereof, PIPES (piperazine-N,N′

-bis(2-ethanesulfonic acid) and salts thereof, TES (N-[Tris(hydroxymethyl)methyl]-2-aminoethanesulfonic acid) and salts thereof, and mixtures thereof.

4. The aqueous lens care solution of claim 1, 2, or 3, wherein the aqueous lens care solution further comprises an ozone-reactive dye.

5. The aqueous lens care solution of claim 4, wherein the ozone-reactive dye is selected from the group consisting of FD&

C Blue 1, D&

C Green No. 5, FD&

C Red No. 40, FD&

C Yellow No. 5, and mixtures thereof.

6. The aqueous lens care solution of claim 5, wherein the ozone-reactive dye is FD&

C Blue 1.

7. The aqueous lens care solution of claim 5 or 6, wherein the ozone-reactive dye is present in an amount sufficient to ensure that the aqueous lens care solution becomes colorless under naked eyes over the time period of from about 3 to about 120 minutes, preferably from about 3 to about 90 minutes, more preferably from about 3 to about 60 minutes, even more preferably from about 3 to about 30 minutes, so as to provide a visual indicator for the completion of disinfection and cleaning of contact lenses in the ozone-based lens care system.

8. The aqueous lens care solution of any one of claims 1 to 7, wherein the aqueous lens care solution has a viscosity of about 0.8 to about 15 centipoises at 25°

C., preferably from about 0.8 to about 10 centipoises at 25°

C., more preferably from about 0.9 to about 1.1 centipoises at 25°

C.

9. The aqueous lens care solution of any one of claims 1 to 8, wherein the aqueous lens care solution comprises an antimicrobial agent in an amount effective to preserve the aqueous lens care solution.

10. The aqueous lens care solution of claim 9, wherein the antimicrobial agent is selected from the group consisting of hydrogen peroxide, sodium perborate tetrahydrate, sodium percarbonate, sodium persulfate, and combinations thereof.

11. The aqueous lens care solution of any one of claims 1 to 10, wherein the aqueous lens care solution is formulated in a way that the concentration of ozone generated in the aqueous lens care solution of the invention is controlled in the range from about 0.2 to about 10 ppm.

12. The aqueous lens care solution of any one of claims 1 to 11, wherein the aqueous lens care solution comprises from about 0.005% to about 1% by weight, preferably from about 0.01% to about 0.5% by weight, more preferably from about 0.02% to about 0.25% by weight, even more preferably from about 0.04% to about 0.1% by weight of a surfactant.

13. The aqueous lens care solution of claim 12, wherein the surfactant is selected from the group consisting of polyoxypropylene-polyoxyethylene-polyoxypropylene tri-block copolymers, poly(oxyethylene)-poly(oxybutylene) di-block copolymer, polyoxyethylene-polyoxybutylene-polyoxyethylene tri-block copolymer, polyoxybutylene-polyoxyethylene-polybutylene tri-block copolymer, and combinations thereof.

14. The aqueous lens care solution of any one of claims 1 to 13, wherein the aqueous lens care solution further comprises from about 0.002% to about 0.5% by weight, more preferably from about 0.004% to about 0.1% by weight, even more preferably from about 0.005% to about 0.05% by weight of one or more components selected from the group consisting of lubricant(s), conditioning/wetting agent(s), tonicity agent(s), chelating agent(s), defoaming agents, microbicide(s), and combinations thereof.

15. A lens care kit, comprising a lens care solution of any one of claims 1 to 14.