SYSTEM AND METHOD FOR DETERMINING SUBJECT CONDITIONS IN MOBILE HEALTH CLINICAL TRIALS
First Claim
1. A computer-implemented method comprising:
- integrating data that are captured from multiple sources, wherein said data are associated with multiple variables that are evaluated to predict a state of a subject in a clinical trial;
storing the integrated data in a first database;
calculating time intervals in which to collect an optimal amount of said data to predict said subject state;
partitioning said integrated data by classifying a combination of ranges of values for the variables that optimally predicts the subject state;
generating a predictive model based on a classification algorithm to classify said state;
selecting an optimal data source to determine said subject state;
predicting a subject state by using said generated predictive model; and
storing the generated predictive model in a second database.
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Accused Products
Abstract
A method for calculating a subject'"'"'s state or condition comprises integrating data that are captured from multiple sources, storing the integrated data in a first database, calculating time intervals in which to collect an optimal amount of data to predict the subject state, developing a predictive model using a recorded diary or electronic data capture information, testing the model against a portion of the captured data, and applying the predictive model to new data from other sources. The predictive model may determine a subject state that may be a digital bio-marker for a disease condition. A system for predicting subject state is also disclosed.
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Citations
8 Claims
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1. A computer-implemented method comprising:
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integrating data that are captured from multiple sources, wherein said data are associated with multiple variables that are evaluated to predict a state of a subject in a clinical trial; storing the integrated data in a first database; calculating time intervals in which to collect an optimal amount of said data to predict said subject state; partitioning said integrated data by classifying a combination of ranges of values for the variables that optimally predicts the subject state; generating a predictive model based on a classification algorithm to classify said state; selecting an optimal data source to determine said subject state; predicting a subject state by using said generated predictive model; and storing the generated predictive model in a second database. - View Dependent Claims (2, 3, 4)
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5. A system comprising:
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a processor; a model training module configured to receive data from a plurality of mobile health sources and to generate, using the processor, a predictive model of the state of a subject of a clinical trial based on said data and a data source that records said subject state; and a scoring module configured to use the predictive model to calculate, using the processor, subject state for data without the data source that records said subject state. - View Dependent Claims (6, 7, 8)
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Specification