MONITORING TREATMENT COMPLIANCE USING COMBINED PERFORMANCE INDICATORS

• US 20160140986A1
• Filed: 11/12/2015
• Published: 05/19/2016
• Est. Priority Date: 11/17/2014
• Status: Abandoned Application

• Current Assignee: The Invention Science Fund II, L.L.C. (Intellectual Ventures LLC)
• Original Assignee: Elwha LLC (Intellectual Ventures LLC)
• Inventors: Bowers, Jeffrey A., Duesterhoft, Paul, Hawkins, Daniel, Hyde, Roderick A., Jung, Edward K.Y., Kare, Jordin T., Leuthardt, Eric C., Myhrvold, Nathan P., Smith, Michael A., Sweeney, Elizabeth A., Tegreene, Clarence T., Wood, Lowell L. Jr., Wood, Victoria Y.H.
• Application Number:
  US14/939,013
• Publication Number:
  US 20160140986A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 3/112 for measuring diameter of pupils
• CPC Class Codes: A61B 3/113 for determining or recording eye movement
• CPC Class Codes: A61B 5/163 by tracking eye movement, gaze, or pupil change
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61B 5/4803 Speech analysis specially adapted for diagnostic purposes
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: G10L 25/66 for extracting parameters related to health condition detecting or measuring for diagnostic purposes A61B5/00
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/70 relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

Methods and systems for monitoring compliance of a patient with a prescribed treatment regimen are described. Two or more patient activities (including e.g., speech activity) are analyzed to determine compliance with a treatment for a brain-related disorder. Activity is detected unobtrusively during performance of routine activities with activity sensor(s) at the patient location, patient speech is detected during use of a communication system such as a mobile telephone, and activity data is sent to a monitoring system at a monitoring location. Activity and/or speech data is processed at the patient location or monitoring location to identify activity parameters or patterns that indicate whether the patient has complied with the treatment regimen. Patient identity may be determined through biometric identification or other authentication techniques. The system may provide a report to an interested party, for example a medical care provider or insurance company, regarding patient compliance.

Claims

1. A system comprising:

at least one receiving device for use at a monitoring location for receiving at least one activity data signal and at least one audio data signal from a communication system, the at least one audio data signal including audio data representing speech from a patient at a patient location sensed with at least one audio sensor at the patient location during use of the communication system and transmitted to the monitoring location, the patient having a brain-related disorder and a prescribed treatment regimen for treating at least one aspect of the brain-related disorder, the at least one activity data signal including activity data indicative of whether the patient has complied with the prescribed treatment regimen, the activity data representing at least one first activity of the patient;

signal processing circuitry configured to process the at least one activity data signal to determine, based upon the at least one first activity of the patient and at least one second activity of the patient, whether the patient has complied with the prescribed treatment regimen; and

reporting circuitry configured to report a conclusion based on the determination of whether the patient has complied with the prescribed treatment regimen.

5. The system of claim 1, including patient identification circuitry configured to determine a presence of the patient from at least one identity signal received by the at least one receiving device at the monitoring location from the patient location;

wherein the signal processing circuitry is configured to identify patient activity data corresponding to an activity of the patient based at least in part on the determination of the presence of the patient by the patient identification circuitry.

6. The system of claim 5, wherein the identity signal includes at least a portion of the audio data signal, wherein the patient identification circuitry includes speech analysis circuitry for identifying at least a portion of the audio signal data that resembles known speech of the patient, and wherein the signal processing circuitry is configured to identify the patient activity data by identifying activity data corresponding to a portion of the audio signal that resembles known speech of the patient.

25. The system of claim 1, wherein the at least one activity data signal includes non-speech activity data, and wherein the signal processing circuitry is configured to process the at least one activity data signal to identify at least one non-speech activity pattern that corresponds to unprompted performance of a non-speech activity by the patient.

26. The system of claim 1, wherein the at least one activity data signal includes non-speech activity data, and wherein the signal processing circuitry includes an activity analyzer for analyzing the activity data to determine a non-speech activity pattern;

and a comparator for comparing the non-speech activity pattern represented by the activity data with the at least one characteristic activity pattern.

28. The system of claim 1, wherein the activity data signal includes audio data representing patient speech, and wherein the signal processing circuitry includes a speech analyzer for analyzing patient speech in the audio data signal to determine a patient speech pattern.

29. The system of claim 28, wherein the signal processing circuitry includes a comparator for comparing the patient speech pattern determined from the audio data signal with at least one characteristic speech pattern.

38. The system of claim 1, wherein the at least one receiving device is adapted to receive a physiological activity data signal indicative of at least one physiological signal sensed from the patient with at least one physiological sensor.

45. The system of claim 1, including

warning circuitry configured deliver a warning to a threatened party in response to a notification, the notification indicative of a determination that the patient poses a threat based on the at least one first activity and the at least one second activity;

wherein the at least one receiving device is configured to receive the notification from the patient location.

175. The system of claim 5, wherein the identity signal includes at least one of an image signal received from an imaging device at the patient location, a biometric signal from at least one biometric sensor at the patient location, an authentication factor, a security token, a password, a digital signature, a cryptographic key, a cell phone identification code, an electronic serial number, a mobile identification number, a system identification code, and an RFID signal.

176. The system of claim 1, including at least one of an input device for receiving prescription information indicative of the prescribed treatment regimen and a data storage device for storing prescription information indicative of the prescribed treatment regimen.

177. The system of claim 1, including timing circuitry configured to control timing of operation of at least a portion of the system to perform substantially continuously, intermittently, or according to a schedule, at least one of receiving the at least one activity data signal with the at least one receiving device, receiving the at least one audio data signal with the at least one receiving device, processing the at least one activity data signal with the signal processing circuitry, and reporting the conclusion with the reporting circuitry.

178. The system of claim 1, wherein the reporting circuitry includes at least one of a display device, circuitry for generating an email notification, circuitry for transmitting a notification to a wireless device, circuitry for generating an audio alarm, and circuitry for storing a notification in a data storage device.

2-4. -4. (canceled)

7-24. -24. (canceled)

27. (canceled)

30-37. -37. (canceled)

39-44. -44. (canceled)

46. A method of monitoring compliance of a patient with a treatment regimen, comprising:

receiving at least one audio data signal with a receiving device at a monitoring location, the audio data signal including audio data representing speech sensed from a patient at a patient location during use of a communication system, the patient having a brain-related disorder and a prescribed treatment regimen for treating at least one aspect of the brain-related disorder;

receiving at least one activity data signal with the receiving device, the activity data signal including activity data indicative of whether the patient has complied with the treatment regimen, the activity data representing at least one first activity of the patient;

determining with signal processing circuitry at the monitoring location whether the patient has complied with the treatment regimen, based upon the at least one first activity of the patient and upon at least one second activity of the patient; and

reporting with reporting circuitry a conclusion based on the determination of whether the patient has complied with the prescribed treatment regimen.

47. The method of claim 46, including

receiving with the at least one receiving device a notification from the patient location, the notification indicative of a determination of the patient posing a threat based on the at least one first activity and the at least one second activity;

and

delivering a warning to a threatened party in response to the received notification.

50. The method of claim 46, wherein the at least one first activity of the patient and the at least one second activity of the patient are non-verbal activities.

51. The method of claim 46, wherein receiving the at least one activity data signal with the at least one receiving device includes receiving an activity data signal representing the at least one first activity of the patient, and wherein the audio data signal represents the at least one second activity of the patient.

53. The method of claim 46, wherein at least one of the at least one first activity and at least one second activity of the patient corresponds to performance of a non-speech activity.

84. The method of claim 46, including receiving a signal indicative of initiation of treatment of the patient according to the treatment regimen and beginning to receive the at least one audio data signal responsive to receipt of the signal indicative of initiation of treatment of the patient.

88. The method of claim 46, including determining a presence of the patient with patient identification circuitry at the monitoring location from at least one identity signal received at the monitoring location from the patient location, and using the signal processing circuitry to identify patient activity data corresponding to activity of the patient based at least in part on the determination of the presence of the patient by the patient identification circuitry.

108. The method of claim 46, wherein determining with signal processing circuitry at the monitoring location whether the patient has complied with the treatment regimen includes

analyzing the at least one activity data signal to determine at least one of a first activity pattern from the at least one first activity signal and a second activity pattern from the at least one second activity signal;

and

comparing the at least one of the first activity pattern and the second activity pattern signal with at least one characteristic activity pattern.

118. The method of claim 108, including comparing the at least one of the first activity pattern and the second activity pattern with a plurality of characteristic activity patterns.

119. The method of claim 118, including determining which of the plurality of characteristic activity patterns best matches the at least one of the first activity pattern and the second activity pattern.

122. The method of claim 46, wherein determining with signal processing circuitry at the monitoring location whether the patient has complied with the treatment regimen includes

analyzing the at least one activity data signal to determine a first activity pattern from activity data corresponding to first activity;

analyzing the at least one activity data signal to determine a second activity pattern activity corresponding to the second activity;

comparing the first activity pattern with at least one first characteristic activity pattern; and

comparing the second activity pattern with at least one second characteristic activity pattern.

179. The method of claim 53, wherein at least one of the at least one first activity and at least one second activity of the patient is an eye movement activity, a motor activity, typing, providing input via a user interface device, walking, an activity of daily life, performing a hygiene activity, washing, eating, dressing, brushing hair, brushing hair, combing hair, preparing food, interacting with another person, interacting with an animal, interacting with a machine, interacting with an electronic device, or using an implement.

180. The method of claim 46, wherein the activity data signal contains activity data indicative of at least one of a keystroke pattern, an activity performance pattern, an activity performance rate, an activity performance time, an activity performance frequency, an activity performance variability, an activity performance accuracy, an activity performance error rate.

181. The method of claim 46, wherein the activity data signal contains activity data including data from at least one of a pressure sensor, a force sensor, a capacitive sensor, an imaging device, a motion sensor, a motion capture device, an acceleration sensor, and an optical sensor.

182. The method of claim 46, including receiving with the receiving device at least one physiological activity data signal indicative of at least one physiological signal sensed from the patient with at least one physiological sensor, wherein the at least one physiological activity data signal includes at least one of data indicative of whether the patient has complied with the treatment regimen, EEG data, event-related potential data, heart rate data, eye position data, and pupil diameter data.

183. The method of claim 46, including performing at least one of receiving the at least one audio data signal, receiving the at least one activity data signal, determining with the signal processing circuitry, and reporting the conclusion substantially continuously, intermittently, or according to a schedule.

184. The method of claim 88, wherein the identity signal includes at least one of at least a portion of the activity data signal and at least a portion of the audio data signal.

185. The method of claim 88, wherein the identity signal includes an image signal received from an imaging device at the patient location, and wherein determining the presence of the patient with the patient identification circuitry at the monitoring location from the at least one identity signal includes analyzing the image signal to determine the presence of the patient through at least one of facial recognition, gait recognition, or posture recognition.

186. The method of claim 88, wherein the identity signal includes at least one of an image signal received from an imaging device at the patient location and a biometric signal from at least one biometric sensor at the patient location.

187. The method of claim 88, wherein the identity signal includes at least one of an authentication factor, a security token, a password, a digital signature, a cryptographic key, a cell phone identification code, an electronic serial number, a mobile identification number, a system identification code, and an RFID signal.

188. The method of claim 46, including at least one of storing prescription information in a data storage device at the monitoring location, the prescription information indicative of the prescribed treatment regimen;

receiving prescription information indicative of the prescribed treatment regimen; and

prescribing the treatment regimen intended to treat the at least one aspect of the brain-related disorder to the patient.

189. The method of claim 46, wherein receiving the at least one activity data signal includes at least one of receiving a wireless signal, receiving data via a computer network connection, receiving data via a communication port, and receiving data via a data storage device.

190. The method of claim 108, wherein the at least one characteristic activity pattern includes at least one previous activity pattern of the patient or at least one population activity pattern representative of a typical activity pattern of a population of subjects.

191. The method of claim 108, wherein the at least one characteristic activity pattern includes at least one previous activity pattern of the patient, wherein the at least one previous activity pattern is representative of an activity pattern of the patient prior to initiation of treatment of the brain-related disorder, an activity pattern of the patient after initiation of treatment of the brain-related disorder, an activity pattern of the patient during known compliance of the patient with a treatment of the brain-related disorder, or an activity pattern of the patient during treatment at a specified treatment regimen.

192. The method of claim 108, wherein the at least one characteristic activity pattern includes at least one population activity pattern representative of a typical activity pattern of a population of subjects selected from a population without the brain-related disorder, an untreated population with the brain-related disorder, and a population having the brain-related disorder stabilized by a treatment regimen.

193. The method of claim 119, including determining a treatment regimen corresponding to the characteristic activity pattern that best matches the at least one of the first activity pattern and the second activity pattern, wherein the plurality of characteristic activity patterns include a plurality of previous activity patterns each representative of an activity pattern of the patient undergoing a different treatment regimen for treatment of the brain-related disorder or a plurality of population activity patterns each representative of a typical activity pattern for a population of subjects undergoing a different treatment regimen for treatment of the brain-related disorder.

194. The method of claim 46, wherein reporting a conclusion based on the determination of whether the patient has complied with the prescribed treatment regimen includes at least one of displaying a report on a display device, generating an email notification, transmitting a notification to a wireless device, generating an audio alarm, and storing a notification in a data storage device.

195. The method of claim 46, wherein determining, based upon the activity data signal, whether the patient has complied with the prescribed treatment regimen includes at least one of determining that the patient has failed to comply with the prescribed treatment regimen, determining that the patient has complied with the prescribed treatment regimen, and determining a degree of compliance of the patient with the prescribed treatment regimen.

196. The method of claim 46, wherein the brain-related disorder includes at least one of an emotional disorder, a personality disorder, a mental disorder, a traumatic brain-injury-related disorder, schizophrenia, Parkinson'"'"'s disease, an Autism Spectrum Disorder, Alzheimer'"'"'s disease, Bipolar Disorder, depression, a psychological disorder, and a psychiatric disorder.

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144. A computer program product comprising:

a non-transitory signal-bearing medium bearing;

one or more instructions for controlling the receiving of at least one audio data signal with a receiving device at a monitoring location, the audio data signal including audio data representing speech sensed from a patient at a patient location during use of a communication system, the patient having a brain-related disorder and a prescribed treatment regimen for treating at least one aspect of the brain-related disorder;

one or more instructions for controlling the receiving of at least one activity data signal with the receiving device, the activity data signal including activity data indicative of whether the patient has complied with the treatment regimen, the activity data representing at least one first activity of the patient;

one or more instructions for determining whether the patient has complied with the treatment regimen, based upon the at least one first activity of the patient and upon at least one second activity of the patient; and

one or more instructions for controlling reporting circuitry to report a conclusion based on the determination of whether the patient has complied with the prescribed treatment regimen.

145-174. -174. (canceled)