SYSTEM GENERATING A CONSTRAINT FIELD, AND MEDICAL DEVICE IMPLEMENTING THE SAME
First Claim
1. Medical system comprising (1) injectable magnetizable nanoparticles and means for injecting the same, and (2) means for applying a physical and/or mechanical constraint to a tumor associated to a neoangiogenic network where, after having been injected, the particles are retained, said means for applying a physical and/or mechanical constraint being a generator releasing a gradient of magnetic field;
- andwhereinthe system is neither a cell construct nor an implant;
the system is not used for treating a tumor by pharmaceutical means;
the particles are not used such as drug carrier or as imaging agent.
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Abstract
Disclosed is a system including (1) an injection device including injectable magnetizable nanoparticles and a component for injecting the same, and (2) a unit for applying a constraint physically and/or mechanically to a tumor associated to an neoangiogenic network where, after having been injected, the particles are retained. Also disclosed is a method for treating tumors, especially tumors associated with a neoangiogenic network, including the steps of: injecting a composition including magnetizable nanoparticles; optionally performing imaging using an imaging device to detect a concentration of nanoparticles retained in the neoangiogenic network; and applying a contact-free constraint onto a tumor in vivo, by a gradient of magnetic field and the application being directed to the tumor region.
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Citations
20 Claims
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1. Medical system comprising (1) injectable magnetizable nanoparticles and means for injecting the same, and (2) means for applying a physical and/or mechanical constraint to a tumor associated to a neoangiogenic network where, after having been injected, the particles are retained, said means for applying a physical and/or mechanical constraint being a generator releasing a gradient of magnetic field;
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wherein the system is neither a cell construct nor an implant; the system is not used for treating a tumor by pharmaceutical means; the particles are not used such as drug carrier or as imaging agent. - View Dependent Claims (2, 3, 4, 5, 13, 14, 15, 16, 17, 18, 19)
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6. A method for treating tumors by physical and/or mechanical means, comprising the steps of:
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injecting a composition containing nanoparticles; and applying physical and/or mechanical means for applying a contact-free constraint onto a tumor in vivo, said physical and/or mechanical means being a gradient of magnetic field and the application being directed to the tumor region; and wherein the method for treating tumors is not a pharmaceutical method. - View Dependent Claims (7, 8, 9, 10, 20)
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11. Method for modifying the cancerous phenotype of cancer cells to normal cells in a tumor region, the method comprising the steps of:
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injecting a composition containing the nanoparticles as described above, such that the nanoparticles are retained by the neoangiogenic network surrounding the tumor; and implementing physical and/or mechanical means for applying a contact-free constraint onto the tumor cells, this means comprising or consisting of a gradient of magnetic field applied on the nanoparticles, in vivo, from an outside source of gradient of magnetic field; and wherein the method for modifying the cancerous phenotype of cancer cells is not a pharmaceutical method. - View Dependent Claims (12)
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Specification