Dynamic Lab on a Chip Based Point-Of-Care Device For Analysis of Pluripotent Stem Cells, Tumor Cells, Drug Metabolites, Immunological Response, Glucose Monitoring, Hospital Based Infectious Diseases, and Drone Delivery Point-of-Care Systems

• US 20160144358A1
• Filed: 01/28/2016
• Published: 05/26/2016
• Est. Priority Date: 01/28/2016
• Status: Abandoned Application

• Current Assignee: Nilesh Patel
• Original Assignee: Nilesh Patel
• Inventors: Patel, Nilesh
• Application Number:
  US15/009,793
• Publication Number:
  US 20160144358A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: G16B 20/00 ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
• CPC Class Codes: G16H 10/40 for data related to laboratory analysis, e.g. patient specimen analysis
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

The invention provides for a novel dynamically configurable point-of-care device for clinical diagnostics and research for analysis of activity associated with pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, cardiovascular diseases, liver cell therapy, cell-cell signaling, epidemic outbreaks, hospital based infectious diseases, pathogens, germ cells, pharmacological compounds, oxidation reduction, microscopy, tomography, flow cytometry, clinical lab testing, and for providing immunoassays, ELISA, electrophoresis, PCR, chromatography, and other laboratory functions. The device comprises a biochemical processing module further comprising a processor and at least one controller, receiving microfluidic elements, sensors, software scripts, an electrically operated interface, flow ports, a user interface, memory, and a communications link, configurable based on analysis of patient data. The invention further provides for multiple-criteria decision analysis for hospital administrators, a wearable device, mobile medical device, molecular electronics configuration, touchscreen recognition, data analytics application, and a drone delivery based point-of-care system.

Claims

1. In accordance with an embodiment, a dynamic point-of-care LOC device for clinical diagnostic and testing and research applications, the device comprising:

a biochemical processing module further comprising;

a processor and at least one controller,

at least one receiving module for receiving at least one patient sample,

at least one microfluidic element including at least one sensor,

at least one first software script for receiving and processing at least one data element from the at least one patient sample,

an electrically operated interface,

a plurality of flow ports,

a user interface,

memory,

a communications link,

wherein the receiving module is operatively configured to receive the at least one patient sample,

wherein the sensor is configured to detect the at least one data element from at least one sample,

wherein the processing module is communicatively linked to the memory,

wherein the processing module is communicatively linked to the sensor for processing the at least one data element from the at least one patient sample,

wherein the processing module is further operatively configured to execute one or more second software script based on the at least one first software script for receiving and processing the at least one data element from the at least one patient sample,

wherein the processing module is operatively linked to the at least one microfluidic element and the electrically operated interface,

wherein the plurality of flow ports is linked to the at least one microfluidic element,

wherein the processor and controller are communicatively,

wherein at least one or more third software script based on the one or more second software script and the at least one software script is communicated between the processor and controller for executing a control signal linked to the user interface for changing at least one aspect of the configuration of the at least one of;

the plurality of flow ports and the at least one microfluidic element based on the at least one data element from the at least one patient sample.

2. The device of claim 1 wherein the sensor comprises one or more of:

enzyme-based electrochemical biosensors, calorimetric, potentiometric, acoustic wave, amperometric, optical, piezoelectric, optoelectronic, surface plasmon resonance, fiber optic, bioluminescent, resonant mirror, crystal resonance, thermistor, nanoscale, carbon nanotube, acoustic, sound, thermal, environmental, optical, mechanical, acceleration, proximity, motion, electric, magnetic, automotive, pressure, velocity, temperature, heat, presence, position, angle, displacement, distance, current, potential, radio, light, imaging, photon, fluid velocity, gyro, and vibration sensors.

3. The device of claim 1 wherein the one or more third software script comprises at least one script for dynamic configuration for enabling one or more of:

analyzing blood glucose levels, analyzing stem cell activity, analyzing tumor cell activity analyzing antimicrobial resistance activity, analyzing activity of one or more pharmacological compounds, analyzing dielectrophoretic separation of cancer cell activity, analyzing germ cell development, analyzing liver cell therapy, analyzing cell-cell signaling, analyzing oral squamous cell carcinoma, analyzing oxidation reduction in human cells, analyzing immunological response in human cells, for analyzing pathogen activity, for providing an immunoassay, for providing a platform for magneto-immunosensing.

4. The device of claim 1 wherein the one or more third software script comprises at least one script for dynamic configuration for enabling analyzing activity of one or more drug metabolites.

5. The device of claim 1 wherein the processor is communicatively linked to a software application.

6. The software application of claim 4, wherein the software is configured to perform a numerical operation.

7. The software application of claim 4, wherein the software is configured to perform a numerical operation.

8. The software application of claim 4, wherein the software is configured to perform Multiple-Criteria Decision Analysis.

9. The software application of claim 4, wherein the software is configured to communicate with one or more of:

a health information system and a lab information system.

10. The software application of claim 4, wherein the software is configured to perform data analysis.

11. The software application of claim 4, wherein the software is configured communicate with at least one external database.

12. The device of claim 1 wherein the one or more third software script comprises at least one script for dynamic configuration for enabling a three-dimensional arrangement of the device.

13. The device of claim 1 wherein the one or more third software script comprises at least one script for dynamic configuration for providing a drone delivery based point-of-care system.

14. The device of claim 1 wherein the processor is communicatively linked to a mobile device.

15. The device of claim 1 wherein the processor is communicatively linked to a network.

16. The device of claim 1 wherein the processor is designed to be worn as a wearable device.

17. The device of claim 1 wherein the processor is communicatively linked to a medical imaging apparatus.

18. The device of claim 1 wherein the at least one microfluidic element includes at least one molecular electronic element.

19. The device of claim 1 wherein the one or more third software script comprises at least one script for dynamic configuration for providing one or more of:

flow cytometry analysis, optical microscopy analysis, lens free microscopy analysis, lens microscopy analysis, and tomography analysis.

20. The device of claim 1 wherein the one or more third software script comprises at least one script for dynamic configuration for enabling one or more of:

DNA electrophoresis, protein electrophoresis, column chromatography, ion exchange chromatography, protein purification, enzyme assay, hormone assay, rapid colony transformation, purification and identification of plasmid DNA, blotting, cell culture, PCR, DNA transformation, chromatography, ELISA, hematological procedures, and clinical laboratory testing.