INTEGRATION OF GLUCOSE DATA TO ADJUST INHALED INSULIN DOSE

• US 20160158471A1
• Filed: 12/03/2015
• Published: 06/09/2016
• Est. Priority Date: 12/05/2014
• Status: Abandoned Application

• Current Assignee: Dance BioPharm Incorporated (Dance Biopharm Holdings, Inc.)
• Original Assignee: Dance BioPharm Incorporated (Dance Biopharm Holdings, Inc.)
• Inventors: Fink, Jim, Molloy, Lisa, Stedman, Ben, Shawver, Michael
• Application Number:
  US14/958,318
• Publication Number:
  US 20160158471A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: A61K 9/0078 for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
• CPC Class Codes: A61M 11/005 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/0085 using ultrasonics spraying or atomising liquids using ultrasonic vibrations in general B05B17/06
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2202/00 Special media to be introduced, removed or treated applying radioactive material A61N5/1028
• CPC Class Codes: A61M 2205/3569 sublocal, e.g. between console and disposable
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/505 Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2230/005 Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/201 Glucose concentration
• CPC Class Codes: A61M 2230/40 Respiratory characteristics

Abstract

An insulin dispenser receives blood glucose readings wirelessly from a blood glucose monitor, and calculates an insulin dose based on the historical response of the particular patient to prior insulin doses. The insulin dispenser preferably nebulizes an insulin-containing fluid for inhalation by the patient.

Claims

1. An insulin dispenser, comprising:

a reservoir for holding an insulin-containing liquid;

a nebulizer for generating a mist of the insulin-containing liquid;

a wireless communication transceiver;

a microprocessor; and

a memory, the memory holding instructions that, when executed by the microprocessor cause the insulin dispenser to, under control of the microprocessor;

receive data from a blood glucose monitor via the wireless communication transceiver, the data indicating measurements of the blood glucose level of a patient over time, including during at least one time period after the patient has received a dose of insulin from the dispenser;

record information describing one or more prior insulin doses dispensed to the patient by the insulin dispenser;

characterize, using the data received from the blood glucose monitor, the patient'"'"'s response to the one or more prior insulin doses;

receive a current reading of the patient'"'"'s blood glucose level from the blood glucose monitor via the wireless communication transceiver;

compute a new insulin dose based in part on the characterization of the patient'"'"'s response to the one or more prior insulin doses and based in part on the current reading of the patient'"'"'s blood glucose level; and

dispense the dose of insulin so that an amount of insulin-containing liquid is nebulized corresponding to the computed new insulin dose, for inhalation by the patient.

2. The insulin dispenser of claim 1, wherein the nebulizer further comprises:

a vibratable mesh plate; and

a dispensing mechanism for dispensing the insulin-containing liquid from the reservoir to the vibratable plate, such that the insulin-containing liquid is nebulized when the vibratable mesh plate is vibrated.

3. The insulin dispenser of claim 1, wherein the wireless communication transceiver is a Bluetooth communication transceiver.

4. The insulin dispenser of claim 1, in combination with the blood glucose monitor.

5. The combination of claim 4, wherein the blood glucose monitor performs continuous blood glucose monitoring.

6. The insulin dispenser of claim 1, further comprising:

a mouthpiece through which the nebulized insulin-containing liquid is supplied to the patient; and

a flow sensor that detects inspiratory flow of the patient inhaling through the mouthpiece;

wherein the nebulizer nebulizes the insulin-containing liquid only during a time or times when the flow sensor indicates that the patient is inhaling through the mouthpiece.

7. The insulin dispenser of claim 6, wherein the nebulization continues during a time or times when the flow sensor indicates that the patient is inhaling through the mouthpiece, until the dose has been nebulized.

8. The insulin dispenser of claim 1, further comprising:

a display; and

one or more user controls;

wherein the instructions, when executed by the microprocessor further cause the insulin dispenser to display the computed new insulin dose on the display; and

receive, via the one or more user controls, an adjustment to the computed dose to specify an adjusted dose before dispensing adjusted dose of insulin-containing liquid.

9. A method of controlling glucose levels in a patient, the method comprising:

receiving, via a wireless communication transceiver, data from a blood glucose monitor, the data indicating the blood glucose level of a patient over time, including during at least one time period after the patient has received a dose of insulin from the dispenser;

recording information describing one or more prior insulin doses dispensed to the patient by the insulin dispenser;

characterizing, using the data received from the blood glucose monitor, the patient'"'"'s response to the one or more prior insulin doses;

receiving a current reading of the patient'"'"'s blood glucose level from the blood glucose monitor via the wireless communication transceiver;

computing a new insulin dose based in part on the characterization of the patient'"'"'s response to the one or more prior insulin doses and based in part on the current reading of the patient'"'"'s blood glucose level; and

dispensing the new insulin dose to the patient.

10. The method of claim 9, wherein dispensing the new insulin dose to the patient comprises:

supplying an insulin-containing liquid to one side of a vibratable mesh plate; and

vibrating the vibratable mesh plate during successive inhalations of the patient until the complete dose has been nebulized.

11. The method of claim 10, wherein the insulin-containing liquid is supplied to the vibratable mesh plate at a rate that is at or below the rate at which the insulin-containing liquid is nebulized by the vibrating mesh plate.

12. The method of claim 11, wherein liquid is supplied to the vibratable mesh plate only during patient inhalation and the vibratable mesh plate is vibrated only during patient inhalation.

13. The method of claim 9, further comprising displaying the computed dose on a display.

14. The method of claim 13, further comprising receiving, via user controls, and adjustment of the computed dose.

15. A system, comprising:

a glucose monitor; and

an insulin dispenser;

wherein the insulin dispenser comprises;

a reservoir for holding an insulin-containing liquid;

a vibratable mesh plate;

a dispensing mechanism for dispensing the insulin-containing liquid from the reservoir to the vibratable plate, such that a the insulin-containing liquid is nebulized when the vibratable mesh plate is vibrated;

a wireless communication transceiver;

a microprocessor; and

a memory, the memory holding instructions that, when executed by the microprocessor cause the insulin dispenser to, under control of the microprocessor;

receive data from a blood glucose monitor via the wireless communication transceiver, the data indicating measurements of the blood glucose level of a patient over time, including during at least one time period after the patient has received a dose of insulin from the dispenser;

record information describing one or more prior insulin doses dispensed to the patient by the insulin dispenser;

characterize, using the data received from the blood glucose monitor, the patient'"'"'s response to the one or more prior insulin doses;

receive a current reading of the patient'"'"'s blood glucose level from the blood glucose monitor via the wireless communication transceiver;

compute a new insulin dose based in part on the characterization of the patient'"'"'s response to the one or more prior insulin doses and based in part on the current reading of the patient'"'"'s blood glucose level; and

dispense the dose of insulin to the vibratable mesh plate so that an amount of insulin-containing liquid is nebulized corresponding to the computed new insulin dose, for inhalation by the patient.