BEAM SHAPING ASSEMBLY FOR NEUTRON CAPTURE THERAPY

• US 20160158579A1
• Filed: 05/06/2015
• Published: 06/09/2016
• Est. Priority Date: 12/08/2014
• Status: Active Grant

• Current Assignee: Neuboron Medtech, Ltd.
• Original Assignee: Neuboron Medtech, Ltd.
• Inventors: Liu, Yuan-Hao, LEE, Pei-Yi
• Granted Patent: US 9,974,979 B2
• Time in Patent Office: Days
• CPC Class Codes: A61N 2005/109 Neutrons
• CPC Class Codes: A61N 2005/1094 Shielding, protecting against radiation
• CPC Class Codes: A61N 2005/1095 Elements inserted into the radiation path within the system, e.g. filters or wedges
• CPC Class Codes: A61N 5/1077 Beam delivery systems
• CPC Class Codes: G21G 4/02 Neutron sources
• CPC Class Codes: G21K 1/10 Scattering devices; Absorbing devices; Ionising radiation filters
• CPC Class Codes: H05H 3/06 Generating neutron beams targets for producing nuclear reactions H05H6/00; neutron sources G21G4/02
• CPC Class Codes: H05H 6/00 Targets for producing nuclear reactions supports for targets or objects to be irradiated G21K5/08 ; preparation of tritium C01B4/00; targets, e.g. pellets for fusion reactions by laser or charged particles beam injection H05H1/22

Abstract

A beam shaping assembly for neutron capture therapy includes a beam inlet, a target having nuclear reaction with an incident proton beam from the beam inlet to produce neutrons forming a neutron beam defining a main axis, a moderator adjoining to the target, a reflector surrounding the moderator, a thermal neutron absorber adjoining to the moderator, a radiation shield arranged inside the beam shaping assembly and a beam outlet. The neutrons are moderated to epithermal neutron energies. An outer surface of the moderator includes at least a first tapered section. The reflector leads the neutrons deviated from the main axis back. The thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy. The radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation.

Claims

1. A beam shaping assembly for neutron capture therapy comprising:

a beam inlet;

a target, wherein the target has nuclear reaction with an incident proton beam from the beam inlet to produce neutrons, and wherein the neutrons form a neutron beam defining a main axis;

a moderator adjoining to the target, wherein the neutrons are moderated by the moderator to epithermal neutron energies, and wherein an outer surface of the moderator includes at least a first tapered section;

a reflector surrounding the moderator, wherein the reflector leads the neutrons deviated from the main axis back to enhance epithermal neutron beam intensity;

a thermal neutron absorber adjoining to the moderator, wherein the thermal neutron absorber is used for absorbing thermal neutrons so as to avoid overdosing in superficial normal tissue during therapy;

a radiation shield arranged inside the beam shaping assembly, wherein the radiation shield is used for shielding leaking neutrons and photons so as to reduce dose of the normal tissue not exposed to irradiation; and

a beam outlet.

2. The beam shaping assembly for neutron capture therapy according to claim 1, wherein the beam shaping assembly is further used for accelerator-based boron neutron capture therapy.

3. The beam shaping assembly for neutron capture therapy according to claim 2, wherein a proton beam is accelerated by means of an accelerator to overcome coulomb repulsion energy of a target atomic nucleus and generate nuclear reaction with the target to produce neutrons, and the target is made of a metal material.

4. The beam shaping assembly for neutron capture therapy according to claim 1, wherein an epithermal neutron energy range ranges from 0.5 eV to 40 keV, a thermal neutron energy range is below 0.5 eV, and a fast neutron energy range is above 40 keV, and the beam shaping assembly reduces the quantity of thermal neutrons and fast neutrons;

and wherein the moderator is made of a material having a cross section for principally acting with fast neutrons but hardly acting with epithermal neutrons, the reflector is made of a material having a high neutron reflection ability, and the thermal neutron absorber is made of a material having a cross section for acting with thermal neutrons.

5. The beam shaping assembly for neutron capture therapy according to claim 4, wherein the moderator is made of at least one of D₂O, AlF₃, Fluental™

, CaF₂, Li₂CO₃, MgF₂ and Al₂O₃.

6. The beam shaping assembly for neutron capture therapy according to claim 4, wherein the reflector is made of at least one of Pb or Ni.

7. The beam shaping assembly for neutron capture therapy according to claim 4, wherein the thermal neutron absorber is made of ⁶Li, and an air passage is arranged between the thermal neutron absorber and the beam outlet.

8. The beam shaping assembly for neutron capture therapy according to claim 1, wherein the radiation shield includes a photon shield and a neutron shield.

9. The beam shaping assembly for neutron capture therapy according to claim 1, wherein the outer surface of the moderator includes a cylindrical section and the first tapered section adjoining to the cylindrical section.

10. The beam shaping assembly for neutron capture therapy according to claim 1, wherein the outer surface of the moderator includes the first tapered section and a second tapered section adjoining to the first tapered section, and a tapering direction of the first tapered section is opposite to a tapering direction of the second tapered section.