FIBRONECTIN BASED SCAFFOLD DOMAIN PROTEINS THAT BIND PCSK9
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
-
Citations
36 Claims
-
1-20. -20. (canceled)
-
21. An isolated polypeptide comprising a fibronectin type III tenth (10Fn3) domain wherein the 10Fn3 has a BC, DE and FG loop, and wherein the BC loop comprises SEQ ID NO:
- 112, the DE loop comprises SEQ ID NO;
138, and the FG loop comprises SEQ ID NO;
156, and wherein the polypeptide binds proprotein convertase subtilisin kexin type (PCSK9). - View Dependent Claims (22, 23, 24, 25, 26, 27, 28)
- 112, the DE loop comprises SEQ ID NO;
-
29. An isolated polypeptide comprising a fibronectin type III tenth (10Fn3) domain, wherein the polypeptide comprises SEQ ID NO:
- 209, and wherein the polypeptide binds proprotein convertase subtilisin kexin type (PCSK9).
- View Dependent Claims (30, 31, 32, 33, 34, 35, 36)
Specification