PARKIN LIGASE ACTIVATION METHODS AND COMPOSITIONS
First Claim
1. A method of activating a Parkin ligase, comprising administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger, wherein the compound can coordinate with a zinc ion, and/or bind or react with a cysteine.
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Accused Products
Abstract
The present invention is directed to methods and compositions for activating a Parkin ligase by administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger. The present invention is also directed to methods of treating and/or reducing the incidence of diseases or conditions related to the activation of Parkin ligase.
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Citations
37 Claims
- 1. A method of activating a Parkin ligase, comprising administering to a subject in need thereof a therapeutically effective amount of a compound that disrupts at least one Parkin ligase zinc finger, wherein the compound can coordinate with a zinc ion, and/or bind or react with a cysteine.
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23. A pharmaceutical composition for activating a Parkin ligase in a subject, comprising an effective amount of a compound or its salt thereof that disrupts at least one Parkin ligase zinc finger, and a pharmaceutically acceptable carrier;
wherein the compound or its salt thereof can coordinate a zinc ion, and/or bind or react with a cysteine. - View Dependent Claims (24, 25)
- 33. A method of activating a Parkin ligase, comprising administering a compound to a subject in need thereof that acts synergistically with Phospho Ubiquitin (pUB) in activating the Parkin ligase.
Specification