EMBOLIZATION DEVICE CONSTRUCTED FROM EXPANSILE POLYMER
First Claim
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1. A device for occlusion of a lumen comprising:
- an elongated hydrogel configured to expand upon contact with an aqueous liquid at a physiological pH to form an expanded hydrogel, wherein the hydrogel comprises a reaction product of;
a monomer; and
a polyether macromer selected from poly(ethylene glycol) di-acrylamide, poly(ethylene glycol) di-acrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, derivatives thereof, or combinations thereof; and
a flexible carrier member having a diameter and configured to house the elongated hydrogel within the diameter, and wherein the flexible carrier member includes at least one gap configured to allow the expanded hydrogel to expand into the at least one gap.
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Abstract
Devices for the occlusion of body cavities, such as the embolization of vascular aneurysms and the like, and methods for making and using such devices. The devices may be comprised of novel expansile materials, novel infrastructure design, or both. The devices provided are very flexible and enable deployment with reduced or no damage to bodily tissues, conduits, cavities, etceteras.
13 Citations
20 Claims
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1. A device for occlusion of a lumen comprising:
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an elongated hydrogel configured to expand upon contact with an aqueous liquid at a physiological pH to form an expanded hydrogel, wherein the hydrogel comprises a reaction product of; a monomer; and a polyether macromer selected from poly(ethylene glycol) di-acrylamide, poly(ethylene glycol) di-acrylate, poly(ethylene glycol) dimethacrylate, poly(ethylene glycol) dimethacrylamide, derivatives thereof, or combinations thereof; and a flexible carrier member having a diameter and configured to house the elongated hydrogel within the diameter, and wherein the flexible carrier member includes at least one gap configured to allow the expanded hydrogel to expand into the at least one gap. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification