MULTIMERIC DUAL-MODALITY BREAST CANCER DIAGNOSTIC AGENTS
First Claim
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1. A dual modality probe having a formula selected from the group consisting of:
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Abstract
The present invention describes dual-modality probes. In particular, the present invention discloses hydroxyapatite specific multimeric bisphosphonate dual-modality MRI and optical probes.
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20 Claims
- 1. A dual modality probe having a formula selected from the group consisting of:
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7. A method of making a dual-modality probe, said method comprising:
(a) providing an organic chelating ligand, wherein said organic chelating ligand selected from the group of; - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A method of making a dual-modality probe, said method comprising:
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(a) reacting a bisphosphonate with a trifunctional linker moiety to result in a trifunctional linker moiety conjugated bisphosphonate; (b) deprotecting one or more functional groups on said trifunctional linker moiety conjugated bisphosphonate to yield one or more free functional groups; (c) conjugating a near infrared fluorophore to result in a near infrared containing trifunctional linker moiety conjugated bisphosphonate carboxylic acid precursor; (d) providing a metal chelate, wherein said metal chelate selected from the group of; - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification