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Human cellular models with biosensors

  • US 20160178635A1
  • Filed: 02/26/2016
  • Published: 06/23/2016
  • Est. Priority Date: 09/05/2013
  • Status: Active Grant
First Claim
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1. An oxygen sensor peptide construct comprising:

  • A binding domain which binds to heme; and

    ,a fluorescent reporter domain, wherein the fluorescent reporter is adapted to fluoresce at wavelengths in the range from 500 nm to 1400 nm;

    wherein the fluorescent reporter domain is adapted to change fluorescent emissions characteristics in response to binding of the heme-binding domain to heme.

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