Electrolytic Diaphragm Pumps Having Rigid Reservoirs
First Claim
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1. An implantable drug-delivery device comprising:
- a rigid housing having an interior;
disposed within the interior of the housing;
a flexible reservoir for containing a therapeutic agent therein,a rigid envelope defining therewithin (i) a rigid reservoir and (ii) an expandable electrolysis chamber comprising therewithin a plurality of electrolysis electrodes and an electrolysis fluid,a diaphragm separating the electrolysis chamber from the rigid reservoir; and
a check valve (i) fluidically connecting the flexible reservoir and the rigid reservoir and (ii) configured to allow flow of liquid from the flexible reservoir to the rigid reservoir but to prevent flow of liquid from the rigid reservoir to the flexible reservoir;
a cannula fluidically coupled to the rigid reservoir and having an exit port outside of the housing;
a refill port fluidically coupled to the flexible reservoir and having an entry port outside of the housing; and
circuitry for operating the electrodes to (i) cause evolution of gas from the electrolysis fluid to thereby expand the electrolysis chamber within the rigid envelope and drive therapeutic agent from the rigid reservoir out through the cannula and (ii) stop evolution of gas from the electrolysis fluid, resulting dissolution of gas back into the electrolysis fluid generating a vacuum within the rigid reservoir sufficient to crack the check valve and at least partially refill the rigid reservoir with therapeutic agent from the flexible reservoir.
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Abstract
In various embodiments, an implantable drug-delivery device features one or more rigid drug reservoirs from which therapeutic agents are administered and which are refilled from a flexible reservoir within the device.
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Citations
17 Claims
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1. An implantable drug-delivery device comprising:
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a rigid housing having an interior; disposed within the interior of the housing; a flexible reservoir for containing a therapeutic agent therein, a rigid envelope defining therewithin (i) a rigid reservoir and (ii) an expandable electrolysis chamber comprising therewithin a plurality of electrolysis electrodes and an electrolysis fluid, a diaphragm separating the electrolysis chamber from the rigid reservoir; and a check valve (i) fluidically connecting the flexible reservoir and the rigid reservoir and (ii) configured to allow flow of liquid from the flexible reservoir to the rigid reservoir but to prevent flow of liquid from the rigid reservoir to the flexible reservoir; a cannula fluidically coupled to the rigid reservoir and having an exit port outside of the housing; a refill port fluidically coupled to the flexible reservoir and having an entry port outside of the housing; and circuitry for operating the electrodes to (i) cause evolution of gas from the electrolysis fluid to thereby expand the electrolysis chamber within the rigid envelope and drive therapeutic agent from the rigid reservoir out through the cannula and (ii) stop evolution of gas from the electrolysis fluid, resulting dissolution of gas back into the electrolysis fluid generating a vacuum within the rigid reservoir sufficient to crack the check valve and at least partially refill the rigid reservoir with therapeutic agent from the flexible reservoir. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. An implantable drug-delivery device comprising:
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a rigid housing having an interior; a cannula having an exit port outside of the housing; a refill port having an entry port outside of the housing; disposed within the interior of the housing; fluidically coupled to the refill port, a flexible reservoir for containing a therapeutic agent therein, a first rigid reservoir, a first check valve (i) fluidically connecting the flexible reservoir and the first rigid reservoir and (ii) configured to allow flow of liquid from the flexible reservoir to the first rigid reservoir but to prevent flow of liquid from the first rigid reservoir to the flexible reservoir, a first expandable electrolysis chamber comprising therewithin a plurality of electrolysis electrodes and an electrolysis fluid, a second rigid reservoir fluidically coupled to the cannula, a second check valve (i) fluidically connecting the first rigid reservoir and the second rigid reservoir and (ii) configured to allow flow of liquid from the first rigid reservoir to the second rigid reservoir but to prevent flow of liquid from the second rigid reservoir to the first rigid reservoir, and a second expandable electrolysis chamber comprising therewithin a plurality of electrolysis electrodes and an electrolysis fluid; circuitry for operating the electrodes of the first electrolysis chamber to (i) cause evolution of gas from the electrolysis fluid in the first electrolysis chamber to thereby expand the first electrolysis chamber and drive therapeutic agent from the first rigid reservoir into the second rigid reservoir and (ii) stop evolution of gas from the electrolysis fluid in the first electrolysis chamber, resulting dissolution of gas back into the electrolysis fluid in the first electrolysis chamber generating a vacuum within the first rigid reservoir sufficient to crack the first check valve and at least partially refill the first rigid reservoir with therapeutic agent from the flexible reservoir; and circuitry for operating the electrodes of the second electrolysis chamber to (i) cause evolution of gas from the electrolysis fluid in the second electrolysis chamber to thereby expand the second electrolysis chamber and drive therapeutic agent from the second rigid reservoir out through the cannula and (ii) stop evolution of gas from the electrolysis fluid in the second electrolysis chamber, resulting dissolution of gas back into the electrolysis fluid in the second electrolysis chamber generating a vacuum within the second rigid reservoir sufficient to crack the second check valve and at least partially refill the second rigid reservoir with therapeutic agent from the first rigid reservoir.
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9. An implantable drug-delivery device comprising:
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a rigid housing having an interior; a cannula having an exit port outside of the housing; a refill port having an entry port outside of the housing; disposed within the interior of the housing; fluidically coupled to the refill port, a flexible reservoir for containing a therapeutic agent therein, a first rigid reservoir fluidically coupled to the cannula, a first check valve (i) fluidically connecting the flexible reservoir and the first rigid reservoir and (ii) configured to allow flow of liquid from the flexible reservoir to the first rigid reservoir but to prevent flow of liquid from the first rigid reservoir to the flexible reservoir, a first expandable electrolysis chamber comprising therewithin a plurality of electrolysis electrodes and an electrolysis fluid, a second rigid reservoir fluidically coupled to the cannula, a second check valve (i) fluidically connecting the flexible reservoir and the second rigid reservoir and (ii) configured to allow flow of liquid from the flexible reservoir to the second rigid reservoir but to prevent flow of liquid from the second rigid reservoir to the flexible reservoir, a second expandable electrolysis chamber comprising therewithin a plurality of electrolysis electrodes and an electrolysis fluid; circuitry for operating the electrodes of the first electrolysis chamber to (i) cause evolution of gas from the electrolysis fluid in the first electrolysis chamber to thereby expand the first electrolysis chamber and drive therapeutic agent from the first rigid reservoir out through the cannula and (ii) stop evolution of gas from the electrolysis fluid in the first electrolysis chamber, resulting dissolution of gas back into the electrolysis fluid in the first electrolysis chamber generating a vacuum within the first rigid reservoir sufficient to crack the first check valve and at least partially refill the first rigid reservoir with therapeutic agent from the flexible reservoir; and circuitry for operating the electrodes of the second electrolysis chamber to (i) cause evolution of gas from the electrolysis fluid in the second electrolysis chamber to thereby expand the second electrolysis chamber and drive therapeutic agent from the second rigid reservoir out through the cannula and (ii) stop evolution of gas from the electrolysis fluid in the second electrolysis chamber, resulting dissolution of gas back into the electrolysis fluid in the second electrolysis chamber generating a vacuum within the second rigid reservoir sufficient to crack the second check valve and at least partially refill the second rigid reservoir with therapeutic agent from the flexible reservoir.
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10. A method for administering a therapeutic agent from an implantable drug-delivery device, the method comprising:
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(a) urging a dose of the therapeutic agent from a rigid reservoir, through a cannula, and out an exit port of the cannula; and (b) thereafter, generating a vacuum within the rigid reservoir, the vacuum inducing flow of therapeutic agent into the rigid reservoir from a flexible reservoir to replace the dose urged from the rigid reservoir. - View Dependent Claims (11, 12, 13, 14, 15)
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16. An implantable drug-delivery device comprising:
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a rigid housing having an interior; disposed within the interior of the housing; a flexible reservoir for containing a therapeutic agent therein, a rigid envelope defining therewithin (i) a rigid reservoir and (ii) a pressure-actuated pump chamber comprising therewithin a reversible pressure-actuation mechanism, a diaphragm separating the pressure-actuated pump chamber from the rigid reservoir; and a check valve (i) fluidically connecting the flexible reservoir and the rigid reservoir and (ii) configured to allow flow of liquid from the flexible reservoir to the rigid reservoir but to prevent flow of liquid from the rigid reservoir to the flexible reservoir; a cannula fluidically coupled to the rigid reservoir and having an exit port outside of the housing; a refill port fluidically coupled to the flexible reservoir and having an entry port outside of the housing; and circuitry for operating the pressure-actuation mechanism to (i) cause an increase in pressure in the pump chamber to thereby expand the pump chamber and drive therapeutic agent from the rigid reservoir out through the cannula and (ii) cause a decrease in pressure in the pump chamber to thereby generate a vacuum within the rigid reservoir sufficient to crack the check valve and at least partially refill the rigid reservoir with therapeutic agent from the flexible reservoir. - View Dependent Claims (17)
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Specification