DEVICES AND METHODS FOR DELIVERING MEDICAMENTS FROM A MULTI-CHAMBER CONTAINER

• US 20160184521A1
• Filed: 10/30/2015
• Published: 06/30/2016
• Est. Priority Date: 01/26/2011
• Status: Active Grant

• Current Assignee: Kaleo, Inc.
• Original Assignee: Kaleo, Inc.
• Inventors: EDWARDS, Eric S., EDWARDS, Evan T., LICATA, Mark J., MEYERS, Paul F., BLONDINO, Frank E.
• Granted Patent: US 10,183,116 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 2005/2013 triggering of discharging means by contact of injector with patient body
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2073 preventing premature release, e.g. by making use of a safety lock
• CPC Class Codes: A61M 2005/208 Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
• CPC Class Codes: A61M 2005/2086 having piston damping means, e.g. axially or rotationally acting retarders
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/315 Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61M 5/3204 Needle cap remover, i.e. devices to dislodge protection cover from needle or needle hub, e.g. deshielding devices
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

An apparatus includes a housing, a medicament container, and a movable assembly. The movable assembly includes a first movable member and a second movable member. The second movable member is configured to move relative to the first movable member to move the movable assembly from a first configuration to a second configuration. A distal end portion of the second movable member is configured to move a plunger disposed within the medicament container in a distal direction when the movable assembly is moved to the second configuration. The movable assembly is configured to move between a first position and a second position to move the medicament container within the housing between a first container position and a second container position.

Claims

1. An apparatus, comprising:

a housing;

a medicament container disposed within the housing; and

a movable assembly including a first movable member and a second movable member, the second movable member configured to move relative to the first movable member to change the movable assembly from a first configuration to a second configuration, a distal end portion of the second movable member configured to move a plunger in a distal direction within the medicament container when the movable assembly changes from the first configuration to the second configuration,

the movable assembly configured to move the medicament container within the housing from a first medicament container position to a second medicament container position when the movable assembly moves from a first position within the housing to a second position within the housing.

2. The apparatus of claim 1, wherein:

the plunger is a first plunger disposed within a proximal end portion of the medicament container, the medicament container includes a second plunger disposed therein spaced apart from the first plunger, the first plunger, a portion of the medicament container and the second plunger collectively defining, at least in part, a first medicament containing portion containing a first substance, the second plunger and a distal end portion of the medicament container collectively defining, at least in part, a second medicament containing portion containing a second substance.

3. The apparatus of claim 2, wherein the second substance is selected from the group consisting of adalimumab, atropine, buprenorphine, certolizumab, cetirizine, diazepam, diphenhydramine, epinephrine, etanercept, exenatide, glucagon, haloperidol, hydroxyzine, insulin, ketorolac, lixisenatide, lorazepam, methotrexate, midazolam, obidoxime chloride, pralidoxime chloride, and combinations thereof.

4. The apparatus of claim 2, wherein the second substance is a substantially dry glucagon formulation, wherein the formulation further comprises a carbohydrate.

5. The apparatus of claim 1, wherein the movable assembly is configured to move the medicament container within the housing after the movable assembly is in the second configuration.

6. The apparatus of claim 1, wherein:

a length of the movable assembly increases when the second movable member moves relative to the first movable member.

7. The apparatus of claim 1, wherein:

a proximal end portion of the second movable member is disposed outside of a proximal end portion of the first movable member when the movable assembly is in the first configuration, the proximal end portion of the second movable member is disposed outside of a distal end portion of the first movable member when the movable assembly is in the second configuration.

8. The apparatus of claim 1, wherein:

the first movable member includes a piston portion configured to move within the medicament container to expel a medicament from the medicament container when the medicament container is in the second medicament container position,

a portion of the second movable member configured to be slidably disposed within the piston portion of the first movable member.

9. The apparatus of claim 1, wherein:

the second movable member includes a retention portion configured to limit movement of the second movable member relative to the first movable member.

10. The apparatus of claim 1, wherein:

the second movable member includes a retention portion configured to limit movement of the second movable member relative to the first movable member when the retention portion is engaged with a release member.

11. The apparatus of claim 1, wherein:

the second movable member includes a first retention portion and a second retention portion, the first retention portion configured to limit movement of the second movable member relative to the first movable member when the movable assembly is in the first configuration, the second retention portion configured to limit movement of the second movable member relative to the first movable member when the movable assembly is in the second configuration.

12. The apparatus of claim 1, wherein:

the first movable member includes a retention portion configured to engage a portion of the housing to maintain the movable assembly in the first position within the housing.

13. The apparatus of claim 1, wherein:

a portion of the second movable member is disposed within the first movable member when the movable assembly is in the first configuration, the portion of the second movable member is disposed outside of the first movable member when the movable assembly is in the second configuration.

14. The apparatus of claim 1, wherein the movable assembly includes an energy storage member configured to produce a force to move the second movable member relative to the first movable member.

15. The apparatus of claim 1, wherein:

a portion of the second movable member is disposed within the first movable member; and

the movable assembly includes a spring disposed within the first movable member and the second movable member, the spring configured to produce a force to move the second movable member relative to the first movable member.

16. The apparatus of claim 1, wherein:

the movable assembly includes a first energy storage member configured to produce a first force to move the second movable member relative to the first movable member; and

the first movable member is configured to be operably coupled to a second energy storage member configured to produce a second force to move the movable assembly from the first position to the second position.

17. The apparatus of claim 1, wherein a portion of the movable assembly is configured to actuate an electronic circuit system when the medicament container is moved from the first medicament container position to the second medicament container position.

18. An apparatus, comprising:

a housing;

a medicament container; and

a movable assembly configured to move a plunger a first distance within the medicament container when the movable assembly moves from a first configuration to a second configuration, a length of the movable assembly increasing when the movable assembly moves from a first configuration to a second configuration,

the movable assembly configured to move the plunger a second distance within the medicament container when the movable assembly moves within the housing after the movable assembly is in the second configuration.