ORAL CARE COMPOSITION

• US 20160193124A1
• Filed: 03/11/2016
• Published: 07/07/2016
• Est. Priority Date: 03/31/2010
• Status: Active Grant

• Current Assignee: Colgate-Palmolive Company
• Original Assignee: Colgate-Palmolive Company
• Inventors: PORTER, Venda, MELLO, Sarita, MORGAN, Andre, PRENCIPE, Michael
• Granted Patent: US 10,441,516 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 2800/624 by macromolecular compounds
• CPC Class Codes: A61K 2800/651 The particulate/core comprising inorganic material
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/21 Fluorides; Derivatives thereof
• CPC Class Codes: A61K 8/25 Silicon; Compounds thereof
• CPC Class Codes: A61K 8/27 Zinc; Compounds thereof
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Abstract

Disclosed are oral care compositions, for example dentifrice compositions, comprising an orally acceptable vehicle, metal oxide particles having an average particle size of no greater than a dentin tubule and a polymeric adherent material for adhering the metal oxide particles in the dentin tubule. The metal oxide particles have a median particle size of 5 microns or less, and may comprise zinc oxide.

Claims

1-23. -23. (canceled)

24. An oral care composition comprising

an orally acceptable vehicle;

metal oxide particles comprising zinc oxide; and

a polymeric adherent material comprising;

at least one of hydroxypropylmethyl cellulose (HPMC), hydroxyethylpropyl cellulose (HEPC), hydroxybutylmethyl cellulose (HBMC), carboxymethyl cellulose (CMC) or combinations thereof, and

at least one of poly (ethylene oxide) polymers, linear polyvinylpyrrolidone (PVP) and cross-linked polyvinylpyrrolidone (PVP), polyethylene glycol (PEG)/polypropylene glycol (PPG) copolymer, ethylene oxide (EO)—

propylene oxide (PO) block copolymers, ester gum, shellac, pressure sensitive silicone adhesives, methacrylates, poly(methyl vinyl ether/maleic anhydride) and poly(methyl vinyl ether/maleic acid) or combinations thereof.

25. The oral care composition according to claim 24, wherein the polymeric adherent material comprises carboxymethyl cellulose, and at least one of linear polyvinylpyrrolidone, cross-linked polyvinylpyrrolidone, poly(methyl vinyl ether/maleic anhydride) and poly(methyl vinyl ether/maleic acid), or combinations thereof.

26. The oral care composition according to claim 24, wherein the composition further comprises one or more of glycerin, sorbitol, propylene glycol and polyethylene glycol.

27. The oral care composition according to claim 24, wherein the composition further comprises polyethylene glycol.

28. The oral care composition according to claim 25, wherein the composition further comprises one or more of glycerin, sorbitol, propylene glycol and polyethylene glycol.

29. The oral care composition according to claim 25, wherein the composition further comprises polyethylene glycol.

30. The oral care composition according to claim 24, further comprising a fluoride ion source.

31. The oral care composition according to claim 30, wherein the fluoride ion source comprises sodium fluoride, ammonium fluoride, monofluorophosphates, stannous fluoride, indium fluoride, amine fluorides or combinations thereof.

32. The oral care composition according to claim 31, wherein the fluoride ion source comprises stannous fluoride.

33. The oral care composition according to claim 29, wherein the composition further comprises a fluoride ion source comprising stannous fluoride.

34. The oral care composition according to claim 24 wherein the metal oxide particles have an average particle size from 1 to 7 microns.

35. The oral care composition according to claim 24 wherein the metal oxide is encapsulated in the polymeric adherent material

36. The oral care composition according to claim 24 wherein the metal oxide particles are present in an amount of up to 5% by weight, based on the total weight of the oral care composition.

37. The oral care composition according to claim 36 wherein the metal oxide particles are present in an amount of from 0.5 to 2% by weight, being based on the total weight of the oral care composition.

38. The oral care composition according to claim 24, further comprising silica particles having an average particle size of 8 microns or less.

39. The oral care composition according to claim 38 wherein the silica particles are present in an amount of up to 10% by weight, based on the total weight of the oral care composition.

40. The oral care composition according to claim 24 which is a dentifrice composition.

41. The oral care composition according to claim 40, which is a toothpaste or a gel.

42. The oral care composition according to claim 24, wherein the composition is formulated into a form selected from a mouth rinse, a gum, a dissolvable lozenge, and a dissolvable film.

43. A method of occluding a dentin tubule within the surface of a mammalian tooth comprising applying to the surface of a mammalian tooth an oral care composition of claim 24.

44. A method of protecting dental surfaces from acid-mediated degradation, comprising applying to the surface of a mammalian tooth an oral care composition of claim 24.

45. A method of maintaining or increasing the systemic health of a mammal comprising applying a composition to an oral surface of a mammal at least once a day for a duration of time, wherein the composition comprises:

a. an oral care composition of claim 24, and

b. an agent selected from chlorhexidine;

alexidine;

hexetidine;

sanguinarine;

benzalkonium chloride;

salicylanilide;

domiphen bromide;

cetylpyridinium chloride (CPC);

tetradecylpyridinium chloride (TPC);

N-tetradecyl-4-ethylpyridinium chloride (TDEPC);

octenidine;

delmopinol;

octapinol;

nisin;

zinc ion agent;

copper ion agent;

essential oils;

furanones;

bacteriocins, ethyllauroyl arginate, extracts of magnolia, a metal ion source, fluoride, stannous ions, arginine bicarbonate, honokiol, magonol, ursolic acid, ursic acid, morin, extract of sea buckthorn, a peroxide, an enzyme, a Camellia extract, a flavonoid, a flavan, halogenated diphenyl ether, creative, and propolis.