TISSUE THICKNESS COMPENSATOR COMPRISING A RESERVOIR

• US 20160199063A1
• Filed: 01/11/2016
• Published: 07/14/2016
• Est. Priority Date: 09/30/2010
• Status: Abandoned Application

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Ethicon Endo-Surgery LLC (Johnson & Johnson)
• Inventors: Mandakolathur Vasudevan, Venkataramanan, Henderson, Cortney E., Aronhalt, Taylor W., Aldridge, Jeffrey L., Scheib, Charles J., Yang, Chunlin, Schall, Christopher J., Baxter, Chester O. III, Shelton, Frederick E., Contiliano, Joseph H., Widenhouse, Tamara, Korvick, Donna L.
• Application Number:
  US14/992,475
• Publication Number:
  US 20160199063A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 17/00234 for minimally invasive surgery A61B17/0218, A61B17/0469, A61B17/12013, A61B17/1285, A61B17/29, A61B17/320016 take precedence
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61B 17/0643 with separate closing member, e.g. for interlocking with staple
• CPC Class Codes: A61B 17/0644 penetrating the tissue, deformable to closed position
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/072 for applying a row of staples in a single action , e.g. the staples being applied simultaneously
• CPC Class Codes: A61B 17/07207 the staples being applied sequentially
• CPC Class Codes: A61B 17/07292 Reinforcements for staple line, e.g. pledgets
• CPC Class Codes: A61B 17/105 Wound clamp magazines for packaging sharps A61B50/3001
• CPC Class Codes: A61B 17/1155 Circular staplers comprising a plurality of staples
• CPC Class Codes: A61B 17/2909 Handles
• CPC Class Codes: A61B 17/295 combined with cutting implements
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable or resorptive
• CPC Class Codes: A61B 2017/003 Steerable
• CPC Class Codes: A61B 2017/00314 Separate linked members
• CPC Class Codes: A61B 2017/00327 with actuating members moving in opposite directions
• CPC Class Codes: A61B 2017/00473 Distal part, e.g. tip or head A61B2017/00464 takes precedence
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61B 2017/00526 : Methods of manufacturing
• CPC Class Codes: A61B 2017/0053 : Loading magazines or sutures into applying tools
• CPC Class Codes: A61B 2017/00818 : Treatment of the gastro-intestinal system
• CPC Class Codes: A61B 2017/00862 : elastic or resilient
• CPC Class Codes: A61B 2017/00884 : enhancing wound closure
• CPC Class Codes: A61B 2017/00889 : antimicrobial, disinfectant
• CPC Class Codes: A61B 2017/00893 : pharmaceutically effective
• CPC Class Codes: A61B 2017/00898 : expandable upon contact with fluid
• CPC Class Codes: A61B 2017/00942 : hydrophilic
• CPC Class Codes: A61B 2017/0641 : having at least three legs as part of one single body
• CPC Class Codes: A61B 2017/07214 : Stapler heads
• CPC Class Codes: A61B 2017/07221 : curved
• CPC Class Codes: A61B 2017/07228 : Arrangement of the staples
• CPC Class Codes: A61B 2017/07235 : containing different staples, e.g. staples of different shapes, sizes or materials
• CPC Class Codes: A61B 2017/07242 : achieving different staple heights during the same shot, e.g. using an anvil anvil having different heights or staples of different sizes
• CPC Class Codes: A61B 2017/0725 : with settable gap between anvil and cartridge, e.g. for different staple heights at different shots
• CPC Class Codes: A61B 2017/07257 : characterised by its anvil
• CPC Class Codes: A61B 2017/07264 : characterised by its staple forming cavities, e.g. geometry or material
• CPC Class Codes: A61B 2017/07271 : characterised by its cartridge
• CPC Class Codes: A61B 2017/07278 : characterised by its sled or its staple holder
• CPC Class Codes: A61B 2017/07285 : characterised by its cutter
• CPC Class Codes: A61B 2017/2902 : characterized by features of the actuating rod
• CPC Class Codes: A61B 2017/2908 : Multiple segments connected by articulations
• CPC Class Codes: A61B 2017/291 : the position of the handle being adjustable with respect to the shaft
• CPC Class Codes: A61B 2017/2919 : details of linkages or pivot points
• CPC Class Codes: A61B 2017/292 : connection of actuating rod to handle, e.g. ball end in recess
• CPC Class Codes: A61B 2017/2923 : Toothed members, e.g. rack and pinion
• CPC Class Codes: A61B 2017/2927 : the angular position of the head being adjustable with respect to the shaft
• CPC Class Codes: A61B 2017/2931 : with releasable head
• CPC Class Codes: A61B 2017/2933 : camming or guiding means
• CPC Class Codes: A61B 2017/2936 : Pins in guiding slots
• CPC Class Codes: A61B 2017/2946 : Locking means
• CPC Class Codes: A61B 2017/320052 : Guides for cutting instruments
• CPC Class Codes: A61B 2050/3008 : having multiple compartments
• CPC Class Codes: A61B 2050/314 : Flexible bags or pouches
• CPC Class Codes: A61B 2090/037 : with a frangible part, e.g. by reduced diameter
• CPC Class Codes: A61B 2090/0801 : Prevention of accidental cutting or pricking
• CPC Class Codes: A61B 2090/0807 : Indication means
• CPC Class Codes: A61B 2090/0811 : for the position of a particular part of an instrument with respect to the rest of the instrument, e.g. position of the anvil of a stapling instrument
• CPC Class Codes: A61B 2090/0814 : Preventing re-use
• CPC Class Codes: A61B 50/30 : Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments for wound clamps A61B17/10; for ligaturing clips A61B17/122; packages or dispensers for surgical gloves or finger-stalls A61B42/40
• CPC Class Codes: A61B 90/92 : coded with colour

Abstract

In various embodiments, a tissue thickness compensator can comprise a compressible extracellular matrix and a bioabsothable material dispersed within the extracellular matrix, wherein the bioapsorption of the bioabsorbable material is configured to leave behind channels in the extracellular matrix. The tissue thickness compensator can also comprise generation means for generating the ingrowth of tissue into the channels. In at least one embodiment, the tissue thickness compensator can comprise dissolvable wicking members which, when dissolved, can leave behind channels in the tissue thickness compensator. In certain embodiments, the tissue thickness compensator can comprise at least one rupturable capsule.

Claims

1. A staple cartridge assembly, comprising:

a cartridge body, comprising;

a first row of staple cavities; and

a second row of staple cavities;

staples, wherein each said staple is at least partially positionable within a said staple cavity, and wherein each said staple is movable between an unfired position and a fired position;

a compressible tissue thickness compensator, wherein said staples are configured to at least partially capture said tissue thickness compensator when said staples are moved between their unfired positions and their fired positions; and

a medicament capsule positioned intermediate said first row of staple cavities and said second row of staple cavities, wherein said staple cavities and said staples are configured and arranged such that said staples do not puncture said medicament capsule when said staples are moved between their unfired positions and their fired positions, and wherein said medicament capsule comprises a shell at least partially comprised of a bioabsorbable material.

2. The staple cartridge assembly of claim 1, wherein said medicament capsule further comprises a medicament positioned within said shell, and wherein after sufficient bioapsorption of said shell said medicament can be released from said medicament capsule.

3. The staple cartridge assembly of claim 2, wherein said shell is configured to flex such that said shell does not rupture when a compressive load is applied thereto.

4. The staple cartridge assembly of claim 1, wherein said medicament capsule comprises a port, and wherein a medicament can be introduced into said shell through said port.

5. The staple cartridge assembly of claim 1, wherein said medicament capsule comprises a network of tubes in fluid communication with each other.

6. A staple cartridge assembly, comprising:

a cartridge body comprising a plurality of staple cavities;

staples, wherein each said staple is at least partially positionable within a said staple cavity, and wherein each said staple is movable between an unfired position and a fired position;

a compressible tissue thickness compensator, wherein said staples are configured to at least partially capture said tissue thickness compensator when said staples are moved between their unfired positions and their fired positions; and

a plurality of medicament capsules positioned within said tissue thickness compensator, wherein each said medicament capsule is positioned over a said staple cavity, and wherein said staple cavities and said staples are configured and arranged such that said medicament capsules are crushed within said staples when said staples are moved between their unfired positions and their fired positions.

7. The staple cartridge of claim 6, wherein each said medicament capsule comprises a tube including a shell and a medicament contained within said shell.

8. The staple cartridge of claim 7, wherein each said tube extends along a tube axis, and wherein each said tube axis extends into a said staple cavity.

9. The staple cartridge of claim 6, wherein said cartridge body further comprises a slot configured to receive a cutting member therein, and wherein said staple cartridge further comprises at least one second medicament capsule positioned over said slot.

10. A staple cartridge assembly, comprising:

a cartridge body comprising a plurality of staple cavities;

staples, wherein each said staple is at least partially positionable within a said staple cavity, and wherein each said staple is movable between an unfired position and a fired position;

a compressible tissue thickness compensator, wherein said staples are configured to at least partially capture said tissue thickness compensator when said staples are moved between their unfired positions and their fired positions; and

a plurality of medicament capsules positioned within said tissue thickness compensator, wherein each said medicament capsule comprises a shell, a cavity defined in said shell, and a medicament positioned in said cavity, wherein said shell comprises a through-hole extending into said cavity, and wherein said medicament can flow out of said medicament capsule through said through-hole.

11. The staple cartridge of claim 10, wherein said tissue thickness compensator is comprised of gelatin.

12. The staple cartridge of claim 11, wherein said shell is comprised of an absorbable polymer.

13. A method of manufacturing a tissue thickness compensator, said method comprising the steps of:

preparing a plurality of capsules including a cavity and at least one opening in communication with the cavity;

placing a medicament in the cavities of the capsules through the openings;

closing the openings of the capsules; and

encapsulating at least a portion of the capsules in a material.

14. The method of claim 13, wherein said encapsulating step comprises the steps of placing the capsules in a fluid and lyophilizing the fluid.

15. The method of claim 13, wherein said encapsulating step comprises the steps of preparing apertures in the material and positioning the capsules in the apertures.

16. The method of claim 13, wherein said closing step comprises the step of heat-staking the capsules to close the openings therein.

17. The method of claim 13, wherein said closing step comprises placing a polymeric material over the openings.

18. The method of claim 13, wherein the capsules comprise hollow tubes, and wherein said preparing step comprises the step of constructing the tubes using an injection molding process.

19. A staple cartridge, comprising:

a cartridge body comprising a deck and a plurality of cavities;

staples removably positioned within some of said cavities;

piercing members removably positioned within some of said cavities, wherein each said piercing member is movable between a unfired position and a fired position when said piercing members are ejected from said cavities; and

a compressible compensator positioned above said deck, wherein said compensator comprises at least one capsule positioned over said piercing members, and wherein said piercing members are configured to pierce said at least one capsule when said piercing members are moved into their fired positions.

20. The staple cartridge of claim 19, wherein each said staple is defined by a staple height, wherein each said piercing member is defined by a piercing height, and wherein said piercing height is shorter than said staple height.

21. The staple cartridge of claim 20, wherein said compressible compensator comprises a tissue-contacting surface, and wherein said piercing members are sized and configured such that said piercing members do not pierce said tissue-contacting surface.

22. The staple cartridge of claim 19, wherein said piercing members are comprised of a bioabsorbable material, and wherein said staples are comprised of stainless steel.

23. The staple cartridge of claim 22, wherein said piercing members further comprise a medicament.

24. A staple cartridge assembly, comprising:

a cartridge body, comprising;

a deck;

a plurality of staple cavities defined in said deck; and

a slot configured to receive a cutting member;

staples, wherein each said staple is removably positioned within a said staple cavity, and wherein each said staple is movable between an unfired position and a fired position;

a compressible tissue thickness compensator, wherein said staples are configured to at least partially capture said tissue thickness compensator when said staples are moved between their unfired positions and their fired positions;

a plurality of first medicament capsules positioned within said tissue thickness compensator; and

a plurality of second medicament capsules positioned within said tissue thickness compensator;

wherein said first medicament capsules and said second medicament capsules are positioned relative to said slot, and wherein the cutting member is configured to incise said first medicament capsules and said second medicament capsules when the cutting member is moved within said slot.

25. The staple cartridge of claim 24, wherein said first medicament capsules and said second medicament capsules are positioned in an alternating arrangement.

26. The staple cartridge of claim 24, wherein said first medicament capsules and said second medicament capsules are positioned within said slot.

27. The staple cartridge of claim 26, wherein said deck comprises a plurality of recesses, and wherein said first medicament capsules and said second medicament capsules are positioned in said recesses.

28. The staple cartridge of claim 24, wherein said first medicament capsules and said second medicament capsules are positioned within said tissue thickness compensator over said slot.

29. A tissue thickness compensator for use with a fastening instrument, said tissue thickness compensator comprising:

a compressible layer configured to be at least partially captured by fasteners; and

a capsule embedded in said compressible layer, wherein said capsule comprises;

a shell comprised of a bioabsorbable material;

a cavity defined within said shell;

a medicament contained within said cavity; and

wicking members extending from said shell, wherein said wicking members are configured to absorb bodily fluids and provide a path for the bodily fluids to flow to said shell.

30. The tissue thickness compensator of claim 29, wherein said bioabsorbable material is a first bioabsorbable material configured to bioabsorb at a first rate, wherein said wicking members are comprised of said first bioabsorbable material, wherein said compressible layer is comprised of a second bioabsobable material configured to bioabsorb at a second rate, and wherein said first rate is greater than said second rate.

31. The tissue thickness compensator of claim 30, wherein the bioabsorption of said wicking members is configured to leave behind channels in said compressible layer.

32. The tissue thickness compensator of claim 30, wherein said bioabsorbable material is comprised of gelatin.

33. The tissue thickness compensator of claim 29, wherein said wicking members comprise support legs configured to support said compressible layer.

34. The tissue thickness compensator of claim 29, wherein said shell comprises an extruded tube.

35. A tissue thickness compensator for use with a fastening instrument, said tissue thickness compensator comprising:

a compressible extracellular matrix;

a bioabsorbable material dispersed within said extracellular matrix, wherein the bioapsorption of said bioabsorbable material is configured to leave behind channels in said extracellular matrix; and

generation means for generating the ingrowth of tissue into said channels.

36. The tissue thickness compensator of claim 35, wherein said generation means comprises at least one of stem cells, platelet rich plasma, and growth factors.

37. The tissue thickness compensator of claim 35, wherein said extracellular matrix is comprised from at least one of skeletonized omentum and a regenerative material.

38. The tissue thickness compensator of claim 35, wherein said extracellular matrix is comprised of randomly-oriented hydrophilic fibers.