WOUND TREATMENT EMPLOYING ANTIMICROBIAL COMPOSITION

• US 20160199322A1
• Filed: 03/19/2016
• Published: 07/14/2016
• Est. Priority Date: 10/08/2011
• Status: Active Grant

• Current Assignee: Next Science IP Holdings Pty., Ltd. (Next Science Ltd.)
• Original Assignee: Next Science, LC
• Inventors: Myntti, Matthew Franco
• Granted Patent: US 9,427,417 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/02 containing liquids as carriers, diluents or solvents
• CPC Class Codes: A01N 25/08 containing solids as carriers or diluents
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 41/04 Sulfonic acids; Derivatives thereof
• CPC Class Codes: A01N 59/00 Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• CPC Class Codes: A01N 59/26 Phosphorus; Compounds thereof
• CPC Class Codes: A01N 61/00 Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
• CPC Class Codes: A61K 31/14 Quaternary ammonium compounds, e.g. edrophonium, choline betaines A61K31/205
• CPC Class Codes: A61K 31/19 Carboxylic acids, e.g. valproic acid salicylic acid A61K31/60
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61K 33/02 Ammonia; Compounds thereof
• CPC Class Codes: A61K 33/04 Sulfur, selenium or tellurium; Compounds thereof
• CPC Class Codes: A61K 33/20 Elemental chlorine; Inorganic compounds releasing chlorine
• CPC Class Codes: A61K 33/24 Heavy metals; Compounds thereof
• CPC Class Codes: A61K 33/32 Manganese; Compounds thereof
• CPC Class Codes: A61K 33/42 Phosphorus; Compounds thereof
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/10 : Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 : Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/34 : Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 8/19 : containing inorganic ingredients
• CPC Class Codes: A61K 8/34 : Alcohols
• CPC Class Codes: A61K 8/347 : Phenols
• CPC Class Codes: A61K 8/365 : Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/37 : Esters of carboxylic acids
• CPC Class Codes: A61K 8/39 : Derivatives containing from 2 to 10 oxyalkylene groups
• CPC Class Codes: A61K 8/41 : Amines
• CPC Class Codes: A61K 8/416 : Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/44 : Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
• CPC Class Codes: A61K 8/463 : containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
• CPC Class Codes: A61K 8/466 : containing sulfonic acid derivatives; Salts
• CPC Class Codes: A61K 8/4926 : having six membered rings
• CPC Class Codes: A61K 8/4973 : with oxygen as the only hetero atom
• CPC Class Codes: A61K 8/498 : having 6-membered rings or their condensed derivatives, e.g. coumarin
• CPC Class Codes: A61K 8/55 : Phosphorus compounds
• CPC Class Codes: A61K 8/602 : Glycosides, e.g. rutin
• CPC Class Codes: A61K 8/86 : Polyethers
• CPC Class Codes: A61K 9/0014 : Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0063 : Periodont
• CPC Class Codes: A61K 9/06 : Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61K 9/08 : Solutions composition of solutions A61K47/00
• CPC Class Codes: A61L 2300/404 : Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 26/0066 : Medicaments; Biocides
• CPC Class Codes: A61P 17/02 : for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 31/04 : Antibacterial agents
• CPC Class Codes: A61Q 11/00 : Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 17/005 : Antimicrobial preparations

Abstract

An aqueous composition with a higher-than-neutral pH includes a significant amount of one or more surfactants and large amounts of osmotically active solutes. This composition, as well as an acidic counterpart and solid materials, can be used in a variety of applications such as wound care, oral care, medical equipment reprocessing, healthcare acquired infection and implant treatment.

Claims

1. A process for reducing bacterial colonization in or around the area of a wound, said process comprising applying to said area a gel that comprises at least one PEG and an aqueous composition having a pH of from 2 to 4, a total solute concentration of from 1.8 to 4.0 Osm/L, and from 0.9 to 1.7 g/L of at least one cationic surfactant, said gel being free of sporicides, antifungals and antibiotics.

2. The process of claim 1 wherein said aqueous composition has a total solute concentration of from 1.8 to 2.8 Osm/L.

3. The process of claim 1 wherein said at least one cationic surfactant comprises benzalkonium chloride.

4. The process of claim 1 wherein said at least one cationic surfactant is benzalkonium chloride.

5. A process for reducing bacterial colonization in or around the area of a wound, said process comprising applying to said area a gel that consists essentially of at least one PEG, an aqueous composition having a pH of from 2 to 4, a total solute concentration of from 1.8 to 4.0 Osm/L, and from 0.9 to 1.7 g/L of at least one cationic surfactant, and optionally one or more of an emollient, a lotion, a humectant, a glycosaminoglycan, an analgesic, colloidal silver and a coalescent.

6. The process of claim 5 wherein said aqueous composition has a total solute concentration of from 1.8 to 2.8 Osm/L.

7. The process of claim 5 wherein said at least one cationic surfactant comprises benzalkonium chloride.

8. The process of claim 5 wherein said at least one cationic surfactant is benzalkonium chloride.

9. A process for reducing bacterial colonization in or around the area of a wound, said process comprising applying to said area a gel that comprises

a) at least one PEG and

b) a composition having a pH of from 2 to 4 and a total solute concentration of from 1.8 to 4.0 Osm/L that consists essentially of

(1) water,

(2) a buffer system that comprises of one or more organic acids and at least one salt of one or more organic acids, and

(3) from 0.9 to 1.7 g/L of at least one cationic surfactant, said gel being free of materials having antimicrobial properties other than those provided by said composition.

10. The process of claim 9 wherein said aqueous composition has a total solute concentration of from 1.8 to 2.8 Osm/L.

11. The process of claim 9 wherein said at least one cationic surfactant comprises benzalkonium chloride.

12. The process of claim 9 wherein said at least one cationic surfactant is benzalkonium chloride.

13. The process of claim 9 wherein said one or more organic acids comprise at least one polyacid.

14. The process of claim 13 wherein said at least one polyacid comprises citric acid.

15. The process of claim 14 wherein said at least one salt of one or more organic acids comprises a salt of a polyacid.

16. The process of claim 9 wherein each of said one or more organic acids is a polyacid.

17. The process of claim 9 wherein said one or more organic acids is citric acid.

18. The process of claim 17 wherein said at least one salt comprises a salt of citric acid.

19. The process of claim 9 wherein said at least one salt is a salt of citric acid.

20. The process of claim 9 wherein said one or more organic acids is acetic acid.