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Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tighten gut mucosal barrier

  • US 20160206666A1
  • Filed: 12/22/2015
  • Published: 07/21/2016
  • Est. Priority Date: 12/22/2014
  • Status: Abandoned Application
First Claim
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1. A genetically engineered bacterium comprising:

  • a) one or more non-native copies of a first gene that encodes a transcription factor protein that is regulated by a reactive nitrogen species (RNS), wherein the expression of the gene is operatively linked to a promoter; and

    b) one or more of;

    i. a second gene encoding a non-native, anti-inflammation molecule;

    ii. a second gene encoding a non-native gut barrier function enhancer molecule; and

    iii. a gene cassette encoding a biosynthetic pathway, wherein the final product of the biosynthetic pathway is an anti-inflammation and/or a barrier function enhancer molecule, whereinthe expression of the second gene or gene cassette in b) is controlled by a tunable regulatory region heterologous to the gene or gene cassette, wherein induction of the tunable regulatory region is directly or indirectly controlled by the transcription factor.

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