T CELL ACTIVATING BISPECIFIC ANTIGEN BINDING MOLECULES
First Claim
1. A T cell activating bispecific antigen binding molecule comprising(i) a first antigen binding moiety which is a Fab molecule capable of specific binding to CD3, and which comprises at least one heavy chain complementarity determining region (CDR) amino acid sequence selected from the group consisting of SEQ ID NO:
- 37, SEQ ID NO;
38 and SEQ ID NO;
39 and at least one light chain CDR selected from the group of SEQ ID NO;
32, SEQ ID NO;
33, SEQ ID NO;
34;
(ii) a second antigen binding moiety capable of specific binding to Folate Receptor 1 (FolR1).
3 Assignments
0 Petitions
Accused Products
Abstract
The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
-
Citations
123 Claims
-
1. A T cell activating bispecific antigen binding molecule comprising
(i) a first antigen binding moiety which is a Fab molecule capable of specific binding to CD3, and which comprises at least one heavy chain complementarity determining region (CDR) amino acid sequence selected from the group consisting of SEQ ID NO: - 37, SEQ ID NO;
38 and SEQ ID NO;
39 and at least one light chain CDR selected from the group of SEQ ID NO;
32, SEQ ID NO;
33, SEQ ID NO;
34;(ii) a second antigen binding moiety capable of specific binding to Folate Receptor 1 (FolR1). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34, 35, 38, 39, 40, 41, 42, 44, 45, 46, 48, 50, 51, 52, 53, 104, 110, 111, 112, 113, 114, 115, 120, 121, 122)
- 37, SEQ ID NO;
-
10-21. -21. (canceled)
-
33. (canceled)
-
36-37. -37. (canceled)
-
43. (canceled)
-
47. (canceled)
-
49. (canceled)
-
54-103. -103. (canceled)
-
105-109. -109. (canceled)
-
116-119. -119. (canceled)
-
123. (canceled)
Specification