METHOD AND/OR SYSTEM FOR MULTICOMPARTMENT ANALYTE MONITORING

• US 20160228042A9
• Filed: 10/22/2012
• Published: 08/11/2016
• Est. Priority Date: 10/25/2011
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Li, Xiaolong, Kannard, Brian T., Shah, Rajiv
• Granted Patent: US 9,907,491 B2
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00

Abstract

Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Claims

1. A method comprising:

modeling a latency in transportation of an analyte between first and second physiological compartments;

compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment; and

compensating for an attenuation of said analyte in the second physiological compartment in estimating said concentration of the analyte in the second physiological compartment.

2. The method of claim 1, wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.

3. The method of claim 2, wherein compensating for said attenuation of said analyte in the second physiological compartment comprises compensating for uptake of glucose from cells.

4. The method of claim 1, wherein said one or more measurements are obtained based, at least in part, on one or more values of a sensor signal, and wherein modeling the latency further comprises modeling the latency based, at least in part, on an estimated rate of change in said sensor signal.

5. The method of claim 4, and wherein the estimated rate of change comprises an estimated first derivative of the sensor signal.

6. The method of claim 4, wherein said sensor signal value comprises a measured current responsive to a concentration of said analyte in said second physiological compartment.

7. The method of claim 4, wherein estimating the concentration of the analyte in the first physiological compartment further comprises:

multiplying the one or more sensor signal value by a first coefficient to provide a first product;

multiplying the estimated rate of change by a second coefficient to provide a second product; and

combining the first and second products with an offset value to provide an estimate of the concentration of the analyte in the first physiological compartment.

8. The method of claim 1, wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient'"'"'s interstitial fluid to affect a blood glucose concentration in said patient.

9. An apparatus comprising:

a sensor to generate a signal responsive to a concentration of an analyte in a second physiological compartment; and

a processor to;

model a latency in transportation of the analyte between the second physiological compartment and a first physiological compartment; and

compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment; and

compensate for an attenuation of said analyte in the second physiological compartment in estimating said concentration of the analyte in the second physiological compartment.

10. The apparatus of claim 9, wherein said sensor signal value comprises a measured current responsive to the concentration of said analyte in said second physiological compartment.

11. The apparatus of claim 9, wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.

12. The apparatus of claim 9, wherein said processor to further compensate for said attenuation of said analyte in the second physiological compartment comprises compensating for uptake of glucose from cells.

13. The apparatus of claim 9, wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient'"'"'s interstitial fluid to affect a blood glucose concentration in said patient.

14. The apparatus of claim 9, the processor further to generate a command to one or more infusion pumps computed based, at least in part, on said estimated concentration.

15. An article comprising:

a non-transitory storage medium having machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to;

model a latency in transportation of an analyte between first and second physiological compartments;

compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment; and

compensate for an attenuation of said analyte in the second physiological compartment in estimating said concentration of the analyte in the second physiological compartment.

16. The article of claim 15, wherein said sensor signal value comprises a measured current responsive to the concentration of said analyte in said second physiological compartment.

17. The article of claim 15, wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.

18. The article of claim 15, wherein said processor to further compensate for said attenuation of said analyte in the second physiological compartment comprises compensating for uptake of glucose from cells.

19. The article of claim 15, wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient'"'"'s interstitial fluid to affect a blood glucose concentration in said patient.

20. An apparatus comprising:

means for modeling a latency in transportation of an analyte between first and second physiological compartments;

means for compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment; and

means for compensating for an attenuation of said analyte in the second physiological compartment in estimating said concentration of the analyte in the second physiological compartment.