NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES USING METATHESIS
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Abstract
Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal-catalyzed metathesis reactions. Also provided are synthetic intermediates that can be used in the synthesis of the prostaglandins and prostaglandin analogs.
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Citations
99 Claims
- 1. A compound of Formula (III):
- 6. A compound of Formula (IV):
- 13. A compound of Formula (V):
- 20. A compound of Formula (VI):
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28. A method for preparing a prostaglandin, prostaglandin analog, or a synthetic intermediate thereof, the method comprising:
providing a compound of Formula (VI); - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
- 57. A method for preparing a compound of Formula (III):
- 59. A method for preparing a compound of Formula (IV):
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61. A method for preparing a compound of Formula (IV):
- 62. A method for preparing a compound of Formula (V):
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64. A method of preparing a compound of Formula (VI):
- 65. A method for preparing a compound of Formula (VII) or Formula (VIII):
- 76. A method for preparing a compound of Formula (IX):
- 78. A compound of Formula (VII) or Formula (VIII):
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84. A compound of Formula (II) or Formula (V-A):
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85. A compound of Formula (VI-A):
- 86. A compound of one of Formulae (XI), (XIV), (XV), or (XVI):
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88. A compound selected from the group comprising:
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89. A method of preparing a prostaglandin, prostaglandin analog, or a synthetic intermediate thereof, the method comprising:
providing a nitro group-containing compound of the formula; - View Dependent Claims (90, 91, 92)
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93. A method of preparing a prostaglandin, prostaglandin analog, or a synthetic intermediate thereof, the method comprising:
providing a compound of the Formulae (VII-6) or (VIII-6); - View Dependent Claims (94)
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95. A method of preparing a prostaglandin, prostaglandin analog, or a synthetic intermediate thereof, the method comprising providing a compound of Formula (X):
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96. A method of preparing a prostaglandin, prostaglandin analog, or a synthetic intermediate thereof, the method comprising:
providing a compound of Formula (I); - View Dependent Claims (97, 98)
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99. A compound of Formula (XII) or (XIII):
Specification