SAMPLE OPTICAL PATHLENGTH CONTROL USING A NONINVASIVE ANALYZER APPARATUS AND METHOD OF USE THEREOF
First Claim
1. An apparatus for spatially separating light for use in noninvasively determining an analyte concentration of a subject, comprising:
- a near-infrared noninvasive analyzer, comprising;
a near-infrared source;
a coupling optic configured to couple light from said near-infrared source with an illumination zone on the subject during use;
a plurality of optically defined detection zones, comprising;
a first detection zone at a first radial distance from the illumination zone; and
a second detection zone at a second radial distance from the illumination zone; and
a set of detectors, comprising;
a first plurality of detectors optically configured to detect light from said first detection zone; and
a second plurality of detectors optically configured to detect light from said second detection zone.
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Abstract
A noninvasive analyzer apparatus and method of use thereof is described for spatially separating light for use in noninvasively determining an analyte concentration of a subject through use of detectors linked to multiple controlled sample illumination zone to sample detection zone distances. The controlled radial separation of illumination and detection zones yields reduced deviation in total observed optical pathlength and/or control of pathlengths in a desired tissue volume for each element of a set of detector elements. Performance using the discrete detection zones is enhanced using a combination of segmented spacers, arcs of detector elements, use of micro-optics, use of optical filters associated with individual detector elements, control of detector response shapes, and/or outlier analysis achievable through use of multiple separate and related observed signals of a detector array.
84 Citations
20 Claims
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1. An apparatus for spatially separating light for use in noninvasively determining an analyte concentration of a subject, comprising:
a near-infrared noninvasive analyzer, comprising; a near-infrared source; a coupling optic configured to couple light from said near-infrared source with an illumination zone on the subject during use; a plurality of optically defined detection zones, comprising; a first detection zone at a first radial distance from the illumination zone; and a second detection zone at a second radial distance from the illumination zone; and a set of detectors, comprising; a first plurality of detectors optically configured to detect light from said first detection zone; and a second plurality of detectors optically configured to detect light from said second detection zone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for spatially separating light for use in noninvasively determining an analyte concentration of a subject, comprising the steps of:
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providing a near-infrared noninvasive analyzer, comprising; a near-infrared source; and a coupling optic; using said coupling optic to couple light from said near-infrared source with an illumination zone on the subject; optically defining a plurality of detection zones on the subject, said plurality of detection zones comprising; a first detection zone at a first radial distance from the illumination zone; and a second detection zone at a second radial distance from the illumination zone; and providing a set of detectors, comprising a first plurality of detectors and a second plurality of detectors; detecting light from said first detection zone using said first plurality of detectors; and detecting light from said second detection zone using said second plurality of detectors. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification