FORMULATIONS OF AZAINDOLE COMPOUNDS
First Claim
1. A pharmaceutical composition comprising:
- a) a HCl salt of Compound (1).xH2O wherein Compound (1) is represented by the following structural formula;
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Accused Products
Abstract
A pharmaceutical composition comprises: a) 5 wt % to 95 wt % of a HCl salt of Compound (1).xH2O by the weight of the pharmaceutical composition, wherein x is from 0 to 3; and b) 5 wt % to 95 wt % of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/mL to 20 mg/mL of Compound (1) in water; and b) 0.01 M to 0.1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1) that includes the HCl salt of Compound (1).xH2O and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HCl salt of Compound (1).xH2O and the pH modifier to form 1 mg/mL to 20 mg/mL of Compound (1) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, and treating influenza each independently employ such pharmaceutical compositions.
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Citations
62 Claims
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1. A pharmaceutical composition comprising:
a) a HCl salt of Compound (1).xH2O wherein Compound (1) is represented by the following structural formula; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
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23. A pharmaceutical composition comprising:
a) 1 mg/mL to 20 mg/mL of Compound (1) in water, wherein Compound (1) is represented by the following structural formula; - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A method of preparing a pharmaceutical composition, comprising:
providing a mixture of Compound (1) comprising; a) 5 wt % to 95 wt % of a HCl salt of Compound (1).xH2O by the weight of the pharmaceutical composition, wherein Compound (1) is represented by the following structural formula; - View Dependent Claims (35, 36, 37, 38, 39, 40, 43, 44, 45, 46, 47, 48)
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41. The method of 40, wherein the step of mixing the binder solution and the pre-granulation composition comprises
i) feeding the intra-granulation composition into a twin screw extruder; - and
ii) introducing the binder solution into the twin screw extruder. - View Dependent Claims (42)
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49. A method of preparing a pharmaceutical composition, comprising:
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mixing a) a HCl salt of Compound (1).xH2O, wherein Compound (1) is represented by the following structural formula; - View Dependent Claims (50, 51)
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Specification