NASAL DELIVERY METHOD

• US 20160250408A1
• Filed: 12/22/2015
• Published: 09/01/2016
• Est. Priority Date: 03/03/1999
• Status: Abandoned Application

• Current Assignee: OptiNose AS (OptiNose, Inc.)
• Original Assignee: OptiNose AS (OptiNose, Inc.)
• Inventors: Djupesland, Per Gisle
• Application Number:
  US14/978,230
• Publication Number:
  US 20160250408A1
• Time in Patent Office: Days
• US Class Current: 1/1
• CPC Class Codes: A61M 15/0018 with exhalation check valves
• CPC Class Codes: A61M 15/002 with air flow regulating means
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0098 Activated by exhalation
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 16/0866 Passive resistors therefor
• CPC Class Codes: A61M 16/1055 bacterial
• CPC Class Codes: A61M 16/1065 in the expiratory path
• CPC Class Codes: A61M 2202/0468 non-physiological
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/43 making noise when used correctly
• CPC Class Codes: A61M 2205/59 Aesthetic features, e.g. distraction means to prevent fears of child patients
• CPC Class Codes: A61M 2206/10 Flow characteristics
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
• CPC Class Codes: A61M 2210/0618 Nose
• CPC Class Codes: A61M 2210/0625 : Mouth
• CPC Class Codes: A61M 3/0202 : with electronic control means or interfaces
• CPC Class Codes: A61M 3/0233 : characterised by liquid supply means, e.g. from pressurised reservoirs
• CPC Class Codes: A61M 3/0279 : Cannula; Nozzles; Tips; their connection means

Abstract

A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Claims

1-34. -34. (canceled)

35. A method of irrigating the nasal airway of a subject, comprising:

sealing a first nostril of a subject to an outlet of a delivery unit;

closing the oropharyngeal velum of the subject; and

delivering an irrigating agent through the outlet of the delivery unit at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other, second nostril of the subject.

36. The method of claim 35, further comprising:

sealing the second nostril of the subject to the outlet of the delivery unit;

closing the oropharyngeal velum of the subject; and

delivering an irrigating agent through the outlet of the delivery unit at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the first nostril of the subject.

37. The method of claim 35, wherein the velum closure is provided by exhalation by the subject.

38. The method of claim 35, wherein the irrigating agent is delivered in an exhalation flow.

39. The method of claim 35, wherein the irrigating agent is delivered by actuation of a supply unit.

40. The method of claim 39, wherein the supply unit is actuated by the exhalation flow of the subject.

41. The method of claim 35, further comprising:

providing a flow resistance to the nasal airway of the subject so as to maintain a dynamic positive pressure in the nasal airway of the subject.

42. The method of claim 41, wherein the dynamic positive pressure is of sufficient magnitude as to force open at least one of the auditory tubes or the sinus tubes.

43. The method of claim 41, wherein the dynamic positive pressure is at least 5 cm H₂O.

44. The method of claim 41, wherein the dynamic positive pressure is at least 50 cm H₂O.

45. The method of claim 41, further comprising:

providing at least one of a visual or an audible signal when a predetermined dynamic positive pressure is achieved in the nasal airway of the subject.

46. The method of claim 35, wherein the irrigating agent comprises a liquid.

47. The method of claim 46, wherein the irrigating agent comprises saline.

48. The method of claim 46, wherein the irrigating agent contains oils or herbs.

49. The method of claim 35, wherein the irrigating agent is delivered in combination with a cleansing agent.

50. The method of claim 35, in the treatment of nasal inflammation.

51. The method of claim 35, in the treatment of rhinitis.

52. The method of claim 35, in the treatment of nasal polyps.

54. The method of claim 35, in the treatment of secretory otitis media.

55. The method of claim 35, in the treatment of reduced olfaction.